Ophthalmology
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Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression
A post hoc analysis of the DRCR Retina Network Protocol AA reveals that automated quantitative leakage index on ultra-widefield fluorescein angiography independently predicts the 4-year risk of DRSS worsening and vision-threatening complica
Restoring Vision in Geographic Atrophy: Subretinal Photovoltaic Implants Achieve Significant Visual Gains in Landmark Clinical Trial
A groundbreaking study published in NEJM demonstrates that the PRIMA subretinal photovoltaic system significantly improves visual acuity in patients with geographic atrophy, marking a major milestone in restorative ophthalmology.
The 22 mm Hg Threshold: Does a Historical Cutoff Still Dictate Modern Glaucoma Management?
A multicenter cohort study of 1.8 million clinic encounters reveals that while clinicians view intraocular pressure as a continuous risk factor, the historical 22 mm Hg cutoff remains a significant psychological trigger for escalating glauc
Donor Diabetes Status Does Not Compromise DMEK Outcomes: 1-Year Results from the DEKS Randomized Clinical Trial
The Diabetes Endothelial Keratoplasty Study (DEKS) confirms that donor diabetes status has no clinically significant impact on 1-year graft success rates or endothelial cell loss after Descemet membrane endothelial keratoplasty (DMEK), faci
NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials
Two Phase 3 trials show that NT-501 encapsulated cell therapy significantly reduces ellipsoid zone area loss in Macular Telangiectasia Type 2. While functional outcomes were inconsistent, the treatment demonstrated a robust neuroprotective
Pentosan Polysulfate Maculopathy Following Subcutaneous Injections for Arthritis: A Case Series
Three cases of pentosan polysulfate maculopathy occurred after subcutaneous administration for arthritis at much lower cumulative doses than oral use, highlighting retinal toxicity risk and need for early detection.
High-Dose Aflibercept 8 mg Demonstrates Sustained Visual Gains and Durability in Polypoidal Choroidal Vasculopathy
This post hoc analysis of the PULSAR trial reveals that aflibercept 8 mg provides noninferior visual outcomes and comparable anatomic regression to standard 2 mg dosing in PCV patients, while allowing for significantly extended treatment in
Medical and Surgical Treatments for Neurotrophic Keratopathy: What Randomized Trials Tell Us (and What They Don’t)
A Cochrane review of seven RCTs (494 participants) finds low- to very low-certainty evidence that select medical therapies — notably recombinant human nerve growth factor — may improve corneal re-epithelialization in neurotrophic keratopath
Which Patients with Open-Angle Glaucoma Progress Faster? Key Prognostic Factors from a Cochrane Synthesis
A Cochrane review of 22 cohort studies (6,082 patients) found bilateral disease, disc haemorrhage, female sex, and active treatment have the most consistent associations with visual-field progression in open-angle glaucoma, but overall evid
Clinical Findings and Molecular Genetics of USH1C-Associated Usher Syndrome: A Retrospective Case Series
This case series reviews clinical features, genetic variants, visual outcomes, and psychosocial impact in 28 patients with USH1C-associated Usher syndrome, highlighting slow retinal degeneration and significant social burden.
Rigid Gas-Permeable Contact Lenses Improve Visual Rehabilitation After Primary Congenital Glaucoma Surgery: Results of the CLEVR‑PCG Randomized Trial
In children after primary congenital glaucoma surgery with poor spectacle response, rigid gas‑permeable contact lenses produced greater improvements in worse‑eye visual acuity, contrast sensitivity, and near stereoacuity over 12 months comp
Five-Year Visual Outcomes After Lensectomy for Childhood Traumatic Cataract: Modest Vision Gains but High Rates of Visual Axis Opacification in Pseudophakia
A prospective PEDIG cohort found modest long-term vision after lensectomy for pediatric traumatic cataract, low 5-year glaucoma prevalence, and high 5-year surgery rates for visual axis opacification in pseudophakic eyes, especially without
Manual Marking Without Special Equipment Is Noninferior to Digital Guidance for Capsulorhexis Accuracy in Phacoemulsification
A randomized noninferiority trial found that a device-free manual marking-assisted capsulorhexis (MMAC) produced capsulorhexis diameters and centration comparable to digital guidance (DGAC), supporting a low-cost, widely applicable techniqu
Foundation Models Narrow the Knowledge Gap in Ophthalmology but Struggle with Images
Contemporary foundation models match experts on text-only ophthalmology exam questions but underperform on image-based items; targeted multimodal training and prospective validation are needed before clinical deployment.
Indole-3-Propionic Acid Bridges Gut Dysfunction and Diabetic Retinopathy — A Biomarker and Therapeutic Avenue
A Gut 2025 study identifies microbially produced indole-3-propionic acid (IPA) as a protective metabolite linking restored intestinal tryptophan handling to prevention of diabetic retinopathy in mice and associates low serum IPA with retino
Understanding the FDA’s Rejection of SYD-101: Navigating the Challenges in Pediatric Myopia Treatment
The FDA has rejected Sydnexis’s low-dose atropine eye drop SYD-101 for controlling childhood myopia progression despite promising trial results, highlighting challenges in demonstrating long-term efficacy and clinical significance in new pe
Biodegradable Aflibercept Microsphere‑Hydrogel Shows Long‑Term Ocular Biocompatibility in Rhesus Macaques
A biodegradable PLGA microsphere–thermo‑responsive hydrogel delivering aflibercept was well tolerated after single intravitreal injection in 23 rhesus macaques with preserved retinal structure and function up to 24 months.
Cenegermin Eye Drops Show High Healing Rates in Chinese Patients with Moderate–Severe Neurotrophic Keratopathy
A prospective phase IV open‑label Chinese study found cenegermin achieved corneal healing in 84.6% of stage 2/3 neurotrophic keratopathy patients at 8 weeks, with durable effects through 56 weeks and an acceptable safety profile.
Long-Term Progression and Risk Factors of Diabetic Retinopathy in Type 2 Diabetes: Insights from the Skaraborg Cohort in Sweden
This cohort study tracks diabetic retinopathy incidence over 24 years in type 2 diabetes patients, highlighting the impact of glycemic control and hypertension on disease progression.
Glucagon-Like Peptide-1 Receptor Agonists and Ocular Risks: A Comprehensive Review of Neovascular AMD, Diabetic Retinopathy, and Ischemic Optic Neuropathy in Diabetes
GLP-1 receptor agonists used in diabetes show a twofold increased risk of neovascular AMD, a modest risk elevation for diabetic retinopathy, and a small but significant increased risk for nonarteritic anterior ischemic optic neuropathy, war
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