Evaluating the ISOLD Score for Accurate Diagnosis of Vitreoretinal Lymphoma in Clinical Practice

Highlight

• The ISOLD score demonstrated high diagnostic accuracy for vitreoretinal lymphoma (VRL) using intraocular cytokine levels, especially in aqueous humor (AH) samples.
• The score outperformed the conventional IL-10/IL-6 ratio by providing a continuous probabilistic assessment.
• False-negative results primarily occurred in immunosuppressed patients receiving corticosteroids or chemotherapy, emphasizing clinical context in interpretation.
• Vitreous sample data, though limited, indicate excellent ISOLD performance but require further validation through larger studies.

Study Background