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A Bayesian network meta-analysis comparing FcRn inhibitors, C5 complement inhibitors, and CD19+ B-cell depletion therapies reveals comparable efficacy but varied safety profiles in generalized myasthenia gravis treatment, highlighting the n
A prospective study identifies impaired hearing and high systolic blood pressure as accessible clinical markers associated with silent cerebral infarcts in women after eclampsia, suggesting potential triage tools for neuroimaging and follow
A novel optically guided stroke model targeting the mediodorsal thalamus in mice revealed disruptions in sleep stability, thalamocortical oscillations, and working memory. Auditory stimulation during sleep restored these functions, undersco
Paired vagus nerve stimulation (VNS) combined with rehabilitation achieves significant and durable improvements in upper extremity function, participation, and quality of life up to two years after chronic ischemic stroke, highlighting its
IL-6 receptor blockade significantly reduces relapse rates in MOG antibody-associated disease, showing comparable efficacy to high-dose IVIG with a favorable safety profile, supporting its role in relapse prevention.
The MAD-MT score integrates clinical and procedural factors to optimize mechanical thrombectomy decisions in distal and medium vessel occlusion strokes, guiding tailored treatment and improving functional outcomes.
Plasma phosphorylated tau biomarkers overlap in Alzheimer’s and prion diseases, risking diagnostic confusion. The NfL/p-tau217 ratio emerges as an accurate plasma biomarker to distinguish prion diseases from Alzheimer’s, improving diagnosti
This study reveals that even amateur soccer heading causes immediate, transient increases in blood biomarkers p-tau217 and S100B, indicating acute neural impact and suggesting a dose-response effect.
This study compares triple nerve transfer alone versus combined with fascia lata suspension, finding that fascia lata suspension significantly improves facial function, symmetry, and psychosocial outcomes in patients with severe soft tissue
This review synthesizes evidence linking ischemic placental disease—comprising preeclampsia, placental abruption, and fetal growth restriction—with increased postpartum maternal risk of neurological and psychiatric hospitalizations within o
This study reveals that female stroke patients are less frequently screened for large vessel occlusion (LVO) yet have a higher LVO prevalence and comparable thrombectomy use to males, with better long-term outcomes post-thrombectomy.
This study elucidates how baseline perfusion imaging parameters impact clinical outcomes and safety in isolated posterior cerebral artery occlusions treated with endovascular therapy, highlighting prognostic significance but limited predict
This study reveals significant income and productivity losses up to 15 years before diagnosis in early-onset dementia, varying across subtypes, underscoring the urgent need for earlier detection and support.
Defecation urgency in IBS is a complex symptom intertwining sensory thresholds and emotional processing, reflected in distinct brain structural changes identified through MRI. Differentiating experimentally induced versus real-life urgency
This study identifies a volumetric threshold of 110 mL infarct size beyond which the benefit of thrombectomy diminishes, advocating volumetric assessment over ASPECTS scoring to optimize treatment selection and outcomes in large-core stroke
Recent evidence identifies volumetric thresholds surpassing ASPECTS scoring for optimizing thrombectomy candidacy in large-core ischemic stroke, highlighting a therapeutic ceiling at infarct volumes ≥110 mL.
This study reveals that LRP4 antibody-positive myasthenia gravis constitutes a distinct subgroup marked by higher disease severity and treatment escalation compared to other antibody-defined MG types, emphasizing its unique clinical managem
This study unveils tofersen’s distribution and potent SOD1 reduction within the CNS of SOD1-ALS patients, utilizing autopsy tissues from clinical trial participants, confirming anticipated pharmacokinetic and pharmacodynamic effects.
A phase 3 randomized, placebo-controlled crossover trial demonstrates that levacetylleucine significantly improves neurological function in ataxia-telangiectasia patients with a favorable safety profile.
Mobile Stroke Units enable faster diagnosis and initiation of antihypertensive treatment in intracerebral hemorrhage, significantly reducing time to care compared with conventional EMS transportation.
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