Neurology
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Medical Management Proves Superior to Endovascular Recanalization for Symptomatic Nonacute Intracranial Artery Occlusion
A multicenter cohort study (ERNA-IAO) demonstrates that endovascular recanalization significantly increases the risk of stroke and death compared to medical treatment alone in patients with symptomatic nonacute intracranial artery occlusion
Age and Sex Redefine the Amyloid-to-Tau Transition: Establishing Patient-Centered PET Thresholds for Alzheimer’s Disease
This study establishes patient-centered amyloid PET thresholds for tauopathy onset, revealing that age and sex significantly influence the transition from amyloidosis to tau accumulation. These personalized cut-offs better predict cognitive
Emergent Carotid Stenting for Tandem Lesions Yields Superior One-Year Outcomes: Evidence from the SECURIS Study
The SECURIS study demonstrates that emergent carotid artery stenting (eCAS) for tandem lesions in acute ischemic stroke significantly improves one-year functional outcomes and recanalization success without increasing hemorrhagic risks comp
Emergent Carotid Stenting During Thrombectomy Superior for Tandem Lesion Stroke: Insights From the CERES-TANDEM Study
The CERES-TANDEM study provides Class II evidence that emergent carotid stenting (eCAS) during endovascular thrombectomy for tandem lesions significantly improves 90-day functional outcomes without increasing hemorrhagic risk, supporting it
Emergent Carotid Stenting Redefines Outcomes in Tandem Lesion Stroke: Insights from the CERES-TANDEM Study
The multicenter CERES-TANDEM study provides Class II evidence that emergent carotid stenting (eCAS) during thrombectomy for tandem lesions significantly improves 90-day functional recovery without increasing the risk of symptomatic intracra
Midlife Plasma GFAP as a Long-Term Sentinel for Cerebral Small Vessel Disease: A Decadal Prospective Study
Elevated plasma glial fibrillary acidic protein (GFAP) in middle age independently predicts the progression of cerebral small vessel disease MRI markers nearly a decade later, suggesting its potential as an early-stage prognostic biomarker
Significant 1-Year Risk of Cardiovascular Events in Cognitive Impairment Highlights Safety Concerns for Anti-Amyloid Therapy
A longitudinal study reveals that over 5% of patients with MCI or dementia develop new indications for anticoagulants or thrombolytics within a year, complicating the use of anti-amyloid monoclonal antibodies due to increased intracranial h
Refining Risk Stratification: The IsCHEMiA Score Outperforms Existing Models in Predicting Poststroke Epilepsy
The IsCHEMiA score, an imaging-based risk model validated across international cohorts, offers superior prediction of poststroke epilepsy compared to previous tools. By integrating clinical and neuroimaging markers, it provides a precise fr
Early Postpartum Blood Pressure Optimization Preserves Brain Volume After Hypertensive Pregnancy: Insights from the POP-HT Trial
The POP-HT randomized clinical trial imaging substudy demonstrates that intensive postpartum blood pressure management after hypertensive pregnancy is associated with significantly larger white matter and subcortical brain volumes, suggesti
Neuropsychiatric Interaction with Vascular Health: Deciphering the Moderating Role of PTSD in Hormonal Contraceptive-Associated Cardiovascular Risk
A large-scale cohort study demonstrates that while hormonal contraceptives are generally associated with lower cardiovascular risk in women, this protective effect is lost in those with PTSD, highlighting a critical intersection between psy
Digital Phenotyping in Insomnia: Real-Time Smartphone Assessment Detects Daytime Benefits of Suvorexant Missed by Traditional Scales
A randomized clinical trial demonstrates that smartphone-based ecological momentary assessment (EMA) is significantly more sensitive than retrospective questionnaires in detecting the daytime clinical benefits of suvorexant, particularly re
Adjuvant Temozolomide for IDH-Mutated Anaplastic Astrocytoma: Final CATNON Results Confirm a Decade of Survival Benefit
The final analysis of the EORTC CATNON trial reveals that 12 cycles of adjuvant temozolomide significantly extend overall survival to 12.5 years in IDH-mutated anaplastic astrocytoma, whereas concurrent temozolomide provides no added clinic
Distinct Neuroimaging Signatures: Atrial Fibrillation and Atherosclerosis Drive Divergent Vascular Brain Lesion Patterns
A large-scale comparative study of 3,508 patients reveals that atrial fibrillation and atherosclerosis produce significantly different vascular brain lesions on MRI, with AF favoring non-lacunar infarcts and periventricular white matter cha
Beyond Stenosis: Wall Shear Stress and Oscillatory Index Emerge as Key Biomarkers for High-Risk Carotid Plaques
A study in Eur Heart J Cardiovasc Imaging identifies elevated systolic wall shear stress and low oscillatory shear index as independent predictors of complicated carotid artery plaques, offering a more precise framework for stroke risk stra
DKK2 Inhibition: A Novel Neurovascular Strategy to Salvage the Ischaemic Penumbra and Protect the Blood-Brain Barrier
New research published in the European Heart Journal identifies Dickkopf-related protein 2 (DKK2) as a primary driver of neurovascular injury post-stroke. By suppressing Wnt signalling, DKK2 exacerbates neuronal death and blood-brain barrie
Circumferential Aneurysm Wall Enhancement Predicts a Three-Fold Increase in 4-Year Risk of Instability
A large-scale prospective study in JAMA Neurology identifies circumferential aneurysm wall enhancement (AWE) as a potent independent predictor of intracranial aneurysm growth or rupture, offering a critical radiological biomarker for clinic
Beyond the Lungs: How Ambient Air Pollution Drives Alzheimer’s Neuropathology and Cognitive Decline
Emerging evidence confirms that air pollution, particularly PM2.5 and NO2, is directly associated with Alzheimer’s neuropathology, structural brain changes, and cognitive decline. New research highlights that these effects are partially med
Precision Screening for Preclinical Alzheimer Disease: The Ascendance of Plasma p-tau217 as a Scalable Biomarker
This review synthesizes recent high-impact evidence on plasma p-tau217, demonstrating its superior utility in identifying amyloid pathology, predicting cognitive decline, and optimizing recruitment for primary prevention trials in cognitive
A Global Standard: Understanding the New VasCog-2-WSO Criteria for Vascular Dementia
Experts have released the VasCog-2-WSO criteria, an updated international standard for diagnosing vascular cognitive impairment and dementia. This revision introduces a preclinical stage and incorporates modern neuroimaging and fluid biomar
Early CPAP Intervention May Mitigate Parkinson Disease Risk in Patients with Obstructive Sleep Apnea
A massive cohort study of 11.3 million US veterans reveals that obstructive sleep apnea is an independent risk factor for Parkinson disease, but early treatment with CPAP significantly reduces this risk, particularly in women.
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