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Early continuous creatinine changes within 48 hours after EVT correlate with graded risks of poor 90-day functional outcome and in-hospital mortality, revealing prognostic nuances beyond traditional dichotomous CA-AKI definitions.
This meta-analysis consolidates data from six RCTs comparing left atrial appendage closure (LAAC) to oral anticoagulation for stroke prevention in atrial fibrillation, highlighting reduced bleeding with LAAC but increased ischemic stroke ri
A decade-long analysis reveals a modest decline and delayed timing in withdrawal of life-sustaining treatment among patients with traumatic brain injury, highlighting evolving prognostic attitudes and clinical decision-making.
Peripheral skin nerve fiber loss correlates with cognitive impairment and brain atrophy in Parkinson disease, suggesting a peripheral-central neurodegenerative axis with potential diagnostic value.
This study assesses medium-term cognitive changes in CNS lymphoma patients treated with CAR T-cell therapy, revealing cognitive stability or improvement up to 12 months post-treatment, despite initial neurotoxicity risks.
This phase 2 trial assessed SAR443820, a RIPK1 inhibitor, in ALS patients; it showed no clinical efficacy and increased hepatic side effects, indicating limited therapeutic potential in ALS.
This article explores racial and ethnic disparities in the diagnosis, associated comorbidities, and treatment, particularly chemodenervation, among patients with facial paralysis, highlighting significant differences and healthcare gaps.
In the four-arm SleepCARE trial of 219 women receiving breast cancer chemotherapy, brief CBT-I significantly improved insomnia while bright light therapy did not beat sleep hygiene education. Neither helped fatigue, and combining the two added burden without benefit.
Iatrogenic cerebral amyloid angiopathy (iCAA) exhibits high symptomatic intracerebral hemorrhage rates decades after exposure. This analysis of 82 European cases highlights recurrence risks and cognitive outcomes, informing prognosis and pa
The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive impr
National data show that Comprehensive Stroke Center status and trial participation independently predict reported stroke rates after TAVR, highlighting potential ascertainment bias affecting hospital performance metrics.
In acute ischemic stroke patients with excellent reperfusion, elevated peri-infarct microvascular heterogeneity measured by MRI predicts infarct growth and poor functional recovery, reflecting the no-reflow phenomenon despite restored macro
A retrospective cohort study reveals that shorter duration from migraine onset to trigger-site surgery predicts better postoperative headache frequency reduction, underscoring the benefit of early surgical intervention in medically refracto
This nationwide study reveals that hospitals with higher tendencies for early tracheostomy in severe TBI patients also show increased rates of withdrawal of life-sustaining treatment, highlighting significant practice variability and its po
This study evaluates shunt preservation strategies in adults with ventriculoperitoneal shunts undergoing emergency abdominal surgery, finding low infection rates and favorable outcomes with shunt retention.
This bicentric study evaluates quantitative pupillary light reflex (qPLR) alongside EEG, SSEPs, and NSE for neuroprognostication in comatose post-cardiac arrest patients, revealing strong correlations but limitations in sensitivity and pred
This study evaluates concordance between physician-assessed and patient-reported modified Rankin Scale scores in adults with chronic neurologic disorders in Zambia, revealing substantial agreement but highlighting cultural and symptomatic f
The LIMS study demonstrates sustained, modest improvements in MS-related functioning and dietary behavior up to 24 months following a digital multimodal lifestyle intervention, supporting lifestyle interventions as complementary to MS manag
This article reviews the development and validation of patient-reported outcome measures as interim endpoints in multi-arm multistage trials for progressive multiple sclerosis, highlighting their potential to accelerate therapeutic developm
This longitudinal study investigates plasma biomarker dynamics in Alzheimer’s patients treated with lecanemab, revealing distinct biomarker trajectories that reflect amyloid clearance, tau modulation, and immune responses, offering in
