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This review synthesizes international evidence on survival in genetic frontotemporal dementia (FTD), highlighting key predictors such as age at onset, clinical phenotype, and motor symptoms, and discusses implications for patient care and t
This retrospective analysis reveals that standard antiplatelet therapy may reduce mortality compared to thrombolysis in acute spontaneous spinal cord infarction, highlighting the need for cautious therapeutic decisions pending stronger evid
The VasCog-2-WSO criteria effectively detect MRI-defined vascular cognitive impairment in asymptomatic adults, correlating with increased cardiovascular risk and mortality, highlighting their utility for early diagnosis and community risk s
Serum GFAP elevation predicts progression independent of relapse in MS; therapy-induced GFAP reduction associates with decreased progression risk, supporting GFAP as a biomarker for progression risk stratification and treatment monitoring.
This review synthesizes evidence from a large-scale multi-ancestry study revealing ancestry-specific distributions of Parkinson’s disease genetic variants, emphasizing the need for diverse population inclusion to optimize diagnosis an
This study identifies key prognostic factors and proposes a graded prognostic assessment to stratify survival in patients with brain metastases from nonanaplastic follicular cell-derived thyroid carcinoma.
Intensive blood pressure lowering post-thrombectomy increases acute kidney injury risk, which correlates with poorer neurological outcomes in stroke patients. Careful BP management is crucial to prevent renal complications and optimize reco
This study identifies distinct sleep patterns linked to cognitive performance but finds no significant direct association with dementia risk, highlighting the complexity of sleep-cognition relationships in aging populations.
A 10-year-old with a midbrain ischemic lesion after craniopharyngioma resection developed mutism with features of both akinetic mutism and cerebellar mutism, suggesting a shared neurocircuitry that responded to methylphenidate.
A systematic review and meta-analysis of 18 RCTs found that high-intensity resistance training significantly improved leg press and extension strength in adults aged 50+ compared to low-moderate intensity, with similar effects on bone density and no significant difference in fall incidence or adverse events.
A secondary analysis of the INTERACT3 trial shows that younger adults (≤50 years) with intracerebral hemorrhage have lower mortality and disability but differ in risk factors and may benefit more from bundled care.
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
Among older adults with incident dementia, Alzheimer disease and LATE-NC pathologies were independently linked to higher odds of receiving a timely diagnosis, while vascular pathology and Lewy bodies showed no significant association.
The phase 3b TEMPLE trial found that atogepant 60 mg once daily led to fewer discontinuations due to adverse events and better migraine reduction than topiramate over 24 weeks.
Highlight Agitation is prevalent among dementia patients in nursing homes, often managed with pharmacologic agents.…
A nationwide Danish study links prolonged residential road traffic noise exposure with increased Parkinson disease risk, highlighting the protective effect of having a quiet building facade.
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent
Combining abdominal electrical stimulation with airway clearance improves cough strength, muscle thickness, and decannulation rates in tracheostomized patients with neurologic disorders, without impacting infection or diaphragm mobility.
A large retrospective study reveals a small but significant increase in CNS demyelination risk among patients treated with TNF-α inhibitors, varying by agent, with generally low absolute incidence.
Brain perivascular space morphometry reveals familial microvascular architecture and neuropsychiatric influences, offering a novel imaging biomarker of cerebral microvascular health beyond traditional vascular risk factors.
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