Neurology
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Long-Term Safety and Effectiveness of Personalized Adaptive Deep Brain Stimulation in Parkinson’s Disease
This international trial demonstrates that personalized adaptive deep brain stimulation (aDBS) is a safe, effective, and well-tolerated long-term therapy for Parkinson’s disease patients previously stable on continuous DBS.
Promising Links Between Diabetes Medications and Alzheimer’s Disease Risk Reduction
Recent real-world data suggest GLP-1 receptor agonists and SGLT2 inhibitors may lower Alzheimer’s disease risk more effectively than DPP-4 inhibitors, highlighting the need for randomized trials to confirm potential neuroprotective benefits
Hyperbaric Oxygen Therapy Enhances Recovery After Intracranial Aneurysm Surgery
A meta-analysis of 11 RCTs involving over 2000 patients shows hyperbaric oxygen therapy significantly improves neurologic function, independence, and quality of life post-intracranial aneurysm surgery.
Modifiable Parental Factors Influence Adolescent Sleep
This prospective cohort study identifies modifiable parental factors linked to adolescent sleep outcomes over 4 years, highlighting the mediating roles of screen use and emotional regulation and sex-specific effects, with implications for i
Sleep Disorders in Pregnancy: Unveiling Their Impact on Ischemic Placental Disease and Severe Morbidity
Pregnant individuals with insomnia or obstructive sleep apnea face significantly increased risks of ischemic placental disease, severe maternal morbidity, and preterm birth, highlighting the critical need for early detection and interventio
Long-Term Outcomes in Critically Ill Adults With Acute Encephalitis: Insights From a Multicenter French Cohort
A prospective study of 310 ICU patients with acute encephalitis reveals that half suffer moderate to severe disability or death at 3 months. Autoimmune encephalitis patients show notable recovery over one year, highlighting the need for tai
Intranasal Mesenchymal Stromal Cells for Perinatal Arterial Stroke: Promising Safety and Improved Neurodevelopment at Two Years
The PASSIoN study shows that intranasally administered allogeneic mesenchymal stromal cells in neonates with perinatal arterial ischemic stroke are safe up to two years and suggest better motor outcomes compared to untreated cohorts.
RNS60 as Adjunctive Therapy in Acute Large Vessel Occlusion Stroke: Insights from the RESCUE Trial
The RESCUE trial demonstrates that RNS60, a novel oxygen-supersaturated saline solution, is safe and reduces infarct growth when added to endovascular thrombectomy in acute ischemic stroke due to large vessel occlusion, supporting further i
Safety and Efficacy of Perispinal Etanercept for Chronic Stroke: A Comprehensive Review of Clinical Trial Evidence
Perispinal etanercept is safe but does not improve quality of life in chronic stroke patients, as demonstrated by a Class I randomized trial; translational implications and future research directions are discussed.
Impact of Hypertension History on the Efficacy of Clopidogrel-Aspirin Therapy in Ischemic Stroke Prevention
This study investigates how a history of hypertension influences the effectiveness of combined clopidogrel-aspirin treatment in preventing recurrent strokes after mild ischemic events or high-risk transient ischemic attacks.
Long-term Stroke Risk in Chinese Adults with Newly Diagnosed Diabetes and Impaired Glucose Tolerance: Insights from the 34-Year Da Qing Diabetes Study
A 34-year follow-up of the Da Qing Diabetes Study reveals significantly increased stroke incidence among Chinese adults with newly diagnosed type 2 diabetes and impaired glucose tolerance, highlighting the beneficial impact of lifestyle int
Dissecting the Care Bundle: Mediation Analysis of Key Components Driving Improved Outcomes in INTERACT3 for Acute Intracerebral Hemorrhage
Mediation analysis of INTERACT3 reveals that systolic blood pressure and blood glucose control are primary drivers of functional recovery benefits in acute intracerebral hemorrhage care bundles.
Candesartan 16 mg Shows Promise for Episodic Migraine Prevention: Results from a Robust Phase 2 Randomised Trial
A multi-center, triple-blind phase 2 trial demonstrates that daily candesartan 16 mg significantly reduces migraine days in episodic migraine patients, with tolerable safety profiles, supporting its role as an effective preventive option.
Reevaluating Early Blood Pressure Targets in Acute Spinal Cord Injury: Insights from a Multicenter Randomized Trial
A recent randomized clinical trial comparing augmented to conventional blood pressure targets in acute spinal cord injury found no improvement in 6-month neurological outcomes, challenging current practices and highlighting risks of higher
Intravenous Antihypertensives Post-Endovascular Thrombectomy: Implications for Functional Recovery in Acute Ischemic Stroke
Intravenous antihypertensive use within 24 hours after successful EVT in acute ischemic stroke associates with poorer functional outcomes and higher mortality, underscoring the need for cautious blood pressure management strategies post-thr
Fulmetibant’s Role in Diabetic Neuropathic Pain: Insights from the Phase 2a BRADiNP Study
The BRADiNP study found that fulmetibant, a bradykinin-1 receptor antagonist, failed to significantly reduce diabetic neuropathic pain compared to placebo, despite favorable safety profiles, highlighting challenges in translating preclinica
Pitolisant as Adjunct Therapy for Refractory Restless Legs Syndrome: Insights from a Pilot Study
This pilot study reveals that adjunctive pitolisant, a histamine-3 inverse agonist, is well tolerated and improves symptom scales in refractory restless legs syndrome, suggesting potential to address daytime consequences with minimal core s
Lung-Protective Mechanical Ventilation in Acute Brain Injury: Insights from the PROLABI Trial
The PROLABI trial assessed lung-protective ventilation in acute brain injury patients and found no improvement in mortality, ventilator dependency, or ARDS incidence, highlighting the need for further research in this population.
Electrical Vestibular Stimulation: A Promising Adjunct Therapy for Adult Insomnia in Hong Kong
A double-blind, randomized trial demonstrates that electrical vestibular stimulation (VeNS) significantly reduces insomnia severity and improves quality of life in adults, highlighting a novel non-pharmacological treatment option.
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