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This study establishes patient-centered amyloid PET thresholds for tauopathy onset, revealing that age and sex significantly influence the transition from amyloidosis to tau accumulation. These personalized cut-offs better predict cognitive
The SECURIS study demonstrates that emergent carotid artery stenting (eCAS) for tandem lesions in acute ischemic stroke significantly improves one-year functional outcomes and recanalization success without increasing hemorrhagic risks comp
The CERES-TANDEM study provides Class II evidence that emergent carotid stenting (eCAS) during endovascular thrombectomy for tandem lesions significantly improves 90-day functional outcomes without increasing hemorrhagic risk, supporting it
The multicenter CERES-TANDEM study provides Class II evidence that emergent carotid stenting (eCAS) during thrombectomy for tandem lesions significantly improves 90-day functional recovery without increasing the risk of symptomatic intracra
Elevated plasma glial fibrillary acidic protein (GFAP) in middle age independently predicts the progression of cerebral small vessel disease MRI markers nearly a decade later, suggesting its potential as an early-stage prognostic biomarker
A longitudinal study reveals that over 5% of patients with MCI or dementia develop new indications for anticoagulants or thrombolytics within a year, complicating the use of anti-amyloid monoclonal antibodies due to increased intracranial h
The IsCHEMiA score, an imaging-based risk model validated across international cohorts, offers superior prediction of poststroke epilepsy compared to previous tools. By integrating clinical and neuroimaging markers, it provides a precise fr
The POP-HT randomized clinical trial imaging substudy demonstrates that intensive postpartum blood pressure management after hypertensive pregnancy is associated with significantly larger white matter and subcortical brain volumes, suggesti
A large-scale cohort study demonstrates that while hormonal contraceptives are generally associated with lower cardiovascular risk in women, this protective effect is lost in those with PTSD, highlighting a critical intersection between psy
A randomized clinical trial demonstrates that smartphone-based ecological momentary assessment (EMA) is significantly more sensitive than retrospective questionnaires in detecting the daytime clinical benefits of suvorexant, particularly re
The final analysis of the EORTC CATNON trial reveals that 12 cycles of adjuvant temozolomide significantly extend overall survival to 12.5 years in IDH-mutated anaplastic astrocytoma, whereas concurrent temozolomide provides no added clinic
A large-scale comparative study of 3,508 patients reveals that atrial fibrillation and atherosclerosis produce significantly different vascular brain lesions on MRI, with AF favoring non-lacunar infarcts and periventricular white matter cha
A study in Eur Heart J Cardiovasc Imaging identifies elevated systolic wall shear stress and low oscillatory shear index as independent predictors of complicated carotid artery plaques, offering a more precise framework for stroke risk stra
New research published in the European Heart Journal identifies Dickkopf-related protein 2 (DKK2) as a primary driver of neurovascular injury post-stroke. By suppressing Wnt signalling, DKK2 exacerbates neuronal death and blood-brain barrie
A large-scale prospective study in JAMA Neurology identifies circumferential aneurysm wall enhancement (AWE) as a potent independent predictor of intracranial aneurysm growth or rupture, offering a critical radiological biomarker for clinic
Emerging evidence confirms that air pollution, particularly PM2.5 and NO2, is directly associated with Alzheimer’s neuropathology, structural brain changes, and cognitive decline. New research highlights that these effects are partially med
This review synthesizes recent high-impact evidence on plasma p-tau217, demonstrating its superior utility in identifying amyloid pathology, predicting cognitive decline, and optimizing recruitment for primary prevention trials in cognitive
Experts have released the VasCog-2-WSO criteria, an updated international standard for diagnosing vascular cognitive impairment and dementia. This revision introduces a preclinical stage and incorporates modern neuroimaging and fluid biomar
A massive cohort study of 11.3 million US veterans reveals that obstructive sleep apnea is an independent risk factor for Parkinson disease, but early treatment with CPAP significantly reduces this risk, particularly in women.
A large-scale population-based study in Singapore reveals that acute dengue virus infection is associated with a nearly ten-fold increase in neurological events, including memory loss and movement disorders, particularly in older adults and
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