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A single-center cross-sectional study found that iatrogenic cerebral amyloid angiopathy carries a higher amyloid PET burden, weaker CSF-PET coupling, and less APOE ε4 enrichment than sporadic disease, supporting a biologically distinct mech
In a phase 2 randomized trial, oral vemircopan did not improve clinical outcomes over placebo in AChR-antibody–positive generalized myasthenia gravis, despite a mechanistically attractive strategy to selectively inhibit the alternative comp
In a prospective mild stroke cohort, cranial arterial dolichoectasia and larger intracranial arterial diameters were linked to lacunar stroke, cSVD burden, and incident infarcts, whereas large-artery stenosis was not.
Among older U.S. adults with dementia, non-Hispanic Black and Hispanic individuals were significantly less likely than non-Hispanic White individuals to receive a timely diagnosis, with education and neighborhood affluence explaining much o
Canadian research reveals individuals with cerebral palsy face significantly higher risks of severe maternal complications, preterm birth, and neonatal issues during pregnancy, highlighting the need for specialized perinatal care.
A 24-year Swiss registry study shows modest improvement in pediatric stroke recognition, but most children are still diagnosed beyond thrombolysis and thrombectomy windows.
A U.S. mortality analysis from 1999 to 2020 found increasing deaths from status epilepticus after 2007, with marked disparities by age, sex, race/ethnicity, and region.
A nationwide Danish cohort study found that adults with a first-time seizure had substantially elevated 1-year risks of neurological and nonneurological cancers, with smaller but persistent excess risk over longer follow-up.
In a phase 2 factorial trial, 12 weeks of nicotinamide riboside plus individualized exercise improved cardiopulmonary fitness in Friedreich’s ataxia, with mild-to-moderate adverse events and no signal of major safety concerns.
In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.
Among 114,034 commercially insured patients, the median time to a new neurology visit was 25 days. Waits varied by sex, diagnosis, region, and plan type, while neurologist density showed no association with access.
In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting ur
Secondary analysis of TEMPO-2 trial data reveals intracranial hemorrhage in minor stroke patients increases 90-day mortality risk threefold, with higher hemorrhage rates in tenecteplase-treated patients despite most bleeds being non-symptom
This article reviews a large real-world study demonstrating cenobamate’s superior effectiveness over brivaracetam, lacosamide, and perampanel in reducing seizures for adults with drug-resistant focal epilepsy.
Women with high amyloid-β show higher p-tau217 levels and faster tau accumulation than men, leading to greater cognitive decline. This sex-specific tau response may redefine preclinical Alzheimer’s diagnostics and therapeutics.
Women exhibit higher plasma p-tau217 levels and tau aggregation than men in amyloid-positive individuals, suggesting sex-specific pathways in Alzheimer’s disease progression.
The phase 2 AMULET trial evaluated amlenetug, an anti-α-synuclein monoclonal antibody, in MSA patients. While it did not meet its primary endpoint, the antibody showed a non-significant 19% slowing of disease progression with an acceptable
A retrospective cohort study reveals that stroke-related disability or mortality after ED discharge for dizziness is rare (0.04% incidence), with most lesions occurring in the anterior fossa. Findings underscore the need for targeted risk s
Endovascular thrombectomy (EVT) significantly improves 90-day functional outcomes in acute anterior cerebral artery occlusion stroke compared to standard medical management, without increasing hemorrhage or mortality risks, per the ORIENTAL
A UK Biobank study reveals that optimal sleep (6-8 hours) improves executive function and reduces dementia risk in focal epilepsy patients, with effects surpassing those in stroke patients. Nonoptimal sleep exacerbates cognitive deficits up
