Neurology
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Amyloid PET Centiloid Predicts Lifetime and 10‑Year Risk of MCI and Dementia in Cognitively Unimpaired Adults
A large Mayo Clinic Study of Aging analysis shows lifetime and 10‑year absolute risk of MCI and dementia rise monotonically with amyloid PET centiloid values, modified by age, sex, and APOE ε4 status; out‑of‑study ascertainment substantiall
Validated IMPACT Tool Enables Risk‑Stratified Outpatient Management of Incidental Meningioma
A large international cohort externally validated the IMPACT clinical tool, demonstrating accurate prediction of incidental meningioma progression and supporting triage to early intervention, serial monitoring, or safe discharge.
Targeted Vaccination Is Most Efficient but Not Cost‑Effective: National Serosurvey and Modelling of Japanese Encephalitis in Bangladesh
A nationally representative serosurvey and transmission modelling study in Bangladesh estimates low population-level JEV exposure but large numbers of infections annually; spatially targeted vaccination would be most efficient, though not c
Efficacy and Implementation of a Digital Cognitive Behavioural Self-Management Programme (IBD-BOOST) for Fatigue, Pain, and Faecal Incontinence in Inflammatory Bowel Disease: A Comprehensive Review
This review evaluates the IBD-BOOST digital cognitive behavioural self-management intervention’s design, trial outcomes, process evaluation, and clinical implications for managing fatigue, pain, and faecal incontinence in IBD.
CREST‑2: Stenting Reduces 4‑Year Ipsilateral Stroke vs Intensive Medical Therapy in Asymptomatic High‑Grade Carotid Stenosis; Endarterectomy Shows No Significant Benefit
In CREST‑2, patients with ≥70% asymptomatic carotid stenosis randomized to carotid‑artery stenting plus intensive medical therapy had fewer perioperative-or-ipsilateral strokes over 4 years than intensive medical therapy alone; carotid enda
Intervention Lowers Long‑Term Hemorrhage Risk in Unruptured Brain AVMs: Evidence From a Nationwide Target‑Trial Emulation
A large Chinese registry-based target-trial emulation found interventional therapy for unruptured brain AVMs reduced 5- and 10-year hemorrhage-free survival compared with conservative management, with benefits concentrated in low-grade, com
Uneven Progress: US Central Nervous System Cancer Burden 1990–2021 — Stable Incidence, Falling Mortality, Persistent Geographic and Socioeconomic Disparities
GBD 2021 analysis shows stable overall CNS cancer incidence in the US from 1990–2021, with significant declines in mortality and DALYs but major state-level, age, sex, and SDI-related disparities that demand targeted public-health and clini
Remote Cognitive Training, Structured Rehabilitation and tDCS Failed to Improve Self‑Reported Cognitive Symptoms in Long COVID: Results from a 5‑Arm Phase 2 Randomized Trial
A multicenter phase 2 randomized trial found no differential benefit of adaptive computerized cognitive training, structured cognitive rehabilitation, or transcranial direct current stimulation (tDCS) versus active comparators for self‑repo
Boosting Sleep Apnea Diagnosis After Stroke: A Quality Improvement Breakthrough
A quality improvement program significantly increased obstructive sleep apnea testing in stroke and TIA patients, advancing guideline-based care in cerebrovascular health.
Myocardial Infarction and Late-Onset Epilepsy: Unraveling Bidirectional Vascular Risks in Aging Populations
Emerging cohort evidence reveals myocardial infarction significantly elevates late-onset epilepsy risk, with late-onset epilepsy also predicting subsequent myocardial infarction and vascular mortality, underscoring shared systemic vascular
Unlocking Longevity: The Science of Sleep and Its Vital Role in Health
Quality sleep, balancing deep NREM and REM phases, is crucial for immunity, brain function, and disease prevention, highlighting sleep’s key role in longevity and overall health.
High‑Intensity Interval Training Fails to Rescue Hippocampal Integrity in Adults With Cannabis Use Disorder — but Exercise Is Feasible and May Reduce Craving
A randomized trial in adults with moderate–severe cannabis use disorder found 12 weeks of supervised HIIT did not improve a composite MRI measure of hippocampal integrity versus strength/resistance training; exercise participation was feasi
Is the Gut Microbiome Really a Key to Understanding Autism?
A critical review highlights serious flaws in research linking gut microbiome to autism, questioning its causal role and urging more rigorous studies or reconsideration of this research path.
Emergence of a Novel Mammarenavirus Closely Related to Lassa Virus in a Patient with Meningoencephalitis in Chad
A 37-year-old man developed meningoencephalitis caused by a novel mammarenavirus genetically related to Lassa virus after travel to Chad, highlighting emergence of a new pathogen with distinct clinical features.
Tracking Steps to Slow Alzheimer’s: Physical Activity Linked to Reduced Tau Accumulation and Slower Decline in Preclinical AD
In cognitively unimpaired older adults with elevated amyloid, higher daily step counts were associated with slower inferior-temporal tau accumulation and attenuated cognitive and functional decline, with benefit plateauing around 5,000–7,50
Epidural Stimulation of Lower Thoracic Spinal Cord Restores Blood Pressure Stability After Spinal Cord Injury
An implantable, biomimetic epidural electrical stimulation system targeted to the lowest thoracic spinal segments produced immediate pressor responses and durably reduced hypotensive complications in people with chronic spinal cord injury,
Prolonged Survival Transforms Leptomeningeal Metastasis in NSCLC: Contemporary Multicenter Cohort Shows TKIs and ICIs Improve Outcomes
An international cohort of 2,052 NSCLC patients with leptomeningeal disease shows rising prevalence and improved survival in the modern treatment era. CNS‑penetrant tyrosine kinase inhibitors and immune checkpoint inhibitors are key drivers
Does Anticoagulation After Successful AF Ablation Matter? The OCEAN Trial Shows No Clear Advantage of Rivaroxaban over Aspirin
In patients who underwent successful catheter ablation for atrial fibrillation at least one year earlier, rivaroxaban did not significantly reduce the composite of clinical or covert embolic stroke compared with aspirin over 3 years, while
40‑Hz Light During Sleep Evokes Gamma Activity Without Disrupting Sleep: A Feasibility Step Toward Noninvasive Dementia Therapies
A proof‑of‑concept polysomnography study in 30 healthy adults shows that 40‑Hz visual stimulation during wakefulness, NREM2/3 and REM sleep reliably evokes gamma-band EEG responses without measurable sleep disruption, supporting feasibility
Gamma (40 Hz) Sensory Flicker Shows Promise for Insomnia but Needs Controlled Trials
A prospective observational study of 37 adults with insomnia reports high adherence and no serious adverse events with 40 Hz light–sound flicker and sleep-diary improvements in sleep onset, arousals, and total sleep time; limitations includ
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