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GI biopsies reveal misfolded proteins years before neurological symptoms appear, offering a new biomarker for early neurodegenerative disease prediction and intervention.
High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.
A study reveals significant variability in ALSFRS-R analysis methods across 45 ALS trials, impacting treatment effect estimates and increasing false-positive risks, with implications for clinical decision-making and drug development.
Long-term data from the ULTIMATE open-label extension study demonstrates sustained efficacy and safety of ublituximab in relapsing multiple sclerosis over five years, with significant reductions in relapse rates and disability progression c
A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l
In patients aged under 80 with ASPECTS 0-2, endovascular thrombectomy improved disability outcomes and reduced mortality versus medical care alone, challenging the idea that very large infarcts should automatically exclude treatment.
Resting-state MRI and PET data suggest that corticostriatal networks remodel across nigrostriatal degeneration in Parkinson disease, with posterior caudate hyperconnectivity preceding major motor decline and posterior putaminal disconnectio
In two large U.S. cohorts, greater adherence to healthy dietary patterns—especially DASH—was associated with less subjective cognitive decline and slightly better objective cognition.
A 16-week home-based trial combining testosterone with functional electrical stimulation and arm ergometry improved lean mass and corrected anemia in spinal cord injury patients, though aerobic capacity gains were not statistically signific
A landmark South Korean study of 2.8 million adults reveals that both elevated blood pressure and hypertension significantly increase dementia risk, particularly vascular dementia, with stronger effects observed in midlife adults and women.
This feasibility RCT demonstrates that contingent fMRI neurofeedback targeting the left supramarginal gyrus can improve reading comprehension in stroke survivors with aphasia, outperforming both healthy controls and non-contingent neurofeed
This longitudinal cohort study reveals that biomarker-based biological age, particularly KDMAge and PhenoAge residuals, significantly predicts progression of cerebral small vessel disease, including new lacunes and microbleeds, offering pot
A Brazilian autopsy study of 2,268 individuals reveals that female sex, APOE ε4 status, and African ancestry jointly influence amyloid pathology. Women showed 65% higher adjusted odds of neuritic plaques, and protective effects against amyl
The PINGS trial demonstrates that a 12-month nurse-led mobile health intervention significantly improves blood pressure control among Ghanaian stroke survivors, with 67% achieving target BP versus 43% in usual care. This pragmatic approach
This review synthesizes recent evidence on the neuroprotective effects of healthy dietary patterns (Mediterranean, MIND), the synergistic impact of lifestyle and pharmacotherapy (GLP-1), and systemic advances in acute stroke care and second
A new study reveals that neurologists receiving $1,000 or more from drug manufacturers were over 4 times more likely to prescribe expensive brand-name MS medications when generics were available, driving up costs for patients and the health
A prospective multicenter study demonstrates that teleneurological ward rounds achieve 92% guideline adherence versus 54% for on-site consultations in subacute stroke care, with superiority across all quality domains and most pronounced ben
This review synthesizes recent clinical evidence on the integration of plasma p-tau217 and eMTBR-tau243, highlighting how sequential biomarker testing improves the diagnosis of symptomatic Alzheimer’s disease and predicts longitudinal cogni
Subgroup analysis of the OPTIMAS trial reveals that neither the timing of atrial fibrillation diagnosis nor AF subtype modifies the treatment effect of early versus delayed direct oral anticoagulant initiation in acute ischemic stroke. Pers
A landmark study of 631 participants reveals that normative modeling uncovers substantial individual heterogeneity in brain morphology following traumatic brain injury that conventional group-based analyses miss, with every patient exhibiti
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