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A randomized trial found that levothyroxine treatment for subclinical hypothyroidism or hypothyroxinemia starting between 8 and 20 weeks of gestation did not improve IQ scores in children at age 5 years compared with placebo.
Long-term exposure to particulate matter and lack of green space were associated with increased risk of prediabetes, especially impaired glucose tolerance phenotypes, and reduced remission of isolated impaired fasting glucose.
In a prospective cohort study using multiple 24-hour urine collections, higher sodium excretion was associated with a 32% increased type 2 diabetes risk per 1,000 mg/day; potassium excretion showed no significant association.
A meta-analysis of 23 observational studies shows higher MIND diet adherence is associated with a 55% lower cancer risk and reduced all-cause and CVD mortality. Separately, the MIND trial now provides genetic data to explore precision nutrition for cognitive decline.
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
A cohort of 432 children with Graves disease found 24% developed neutropenia on methimazole, mostly within the first month. TPOAb-negative status and younger age increased risk.
A liver fibrosis risk score (pFIB-6) identifies children with obesity at markedly increased short-term risk of type 2 diabetes, offering a potential tool for early risk stratification.
Severe hypertriglyceridemia (TG >500 mg/dL) affects ~1 in 88 adults and carries risks of pancreatitis and cardiovascular disease. Novel therapies targeting apoC-III, notably plozasiran siRNA, demonstrate dramatic TG reductions and pancreatitis risk mitigation. Pediatric management remains guideline-limited. Standardization of definitions is needed.
This study examines how gestational diabetes and BMI changes between pregnancies impact hospital stay length and birthing costs, highlighting the importance of preventive care.
A propensity-weighted analysis suggests that shorter antithyroid drug therapy (<12 months) in Graves' disease patients with low baseline TRAb is broadly comparable to the standard 12-18 months in preventing relapse, supporting indiv
Acute mild cold exposure with shivering significantly reduces 24-hour glucose levels and improves glycemic profiles in individuals with type 2 diabetes, but not in prediabetic subjects, suggesting a potential non-pharmacological interventio
This analysis of the SOUL trial shows oral semaglutide reduces major cardiovascular events, with greater benefits linked to higher baseline HbA1c and larger HbA1c reductions, while BMI changes did not significantly affect outcomes.
BMI normalization in overweight or obese, autoantibody-positive youths lowers the risk of progression to clinical type 1 diabetes by nearly half, highlighting weight management as a critical preventive strategy in high-risk populations.
GLP-1 receptor agonists significantly reduce atherosclerosis progression, inflammatory biomarkers, and cardiovascular events independent of glycaemic control and obesity status, evidenced by robust preclinical and large-scale clinical data.
Medically tailored groceries modestly improve HbA1c and significantly enhance food and nutrition security among Medicaid-insured adults with type 2 diabetes, supporting ‘Food Is Medicine’ strategies in chronic disease management
This study examines how participant-reported outcomes relate to residual beta cell function and metabolic control in youth newly diagnosed with type 1 diabetes, highlighting modest associations with glucose management but weaker links to be
This nationwide Japanese study elucidates early clinical features of ROHHAD-NET syndrome and highlights anti-ZSCAN1 antibody titers as potential biomarkers linked to neural crest tumors and treatment response.
A pooled analysis of four cohorts reveals that specific IgG N-glycosylation patterns are significantly associated with incident diabetic nephropathy, highlighting immune-related mechanisms in disease progression.
This study evaluates the association between GLP-1 receptor agonists and ischemic optic neuropathy risk compared to SGLT2 and DPP-4 inhibitors, revealing a small but statistically significant increased risk with GLP-1RAs, particularly among
This study reveals significant urban-rural disparities in access to diabetic retinopathy diagnostic and therapeutic services in the U.S., underscoring the need for targeted strategies to improve care in non-urban areas.
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