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This international real-world study demonstrates that osilodrostat effectively controls hypercortisolism in adrenal Cushing syndrome, with improved blood pressure and body weight, and highlights better response in patients previously treate
Hyperreflective abnormalities in middle retinal layers detected by en face OCT improve diagnostic discrimination of referable diabetic retinopathy, offering a promising adjunct biomarker beyond clinical parameters.
The ENDO trial demonstrates that the EndoBarrier duodenal-jejunal bypass liner significantly improves glycemic control and induces meaningful weight loss in patients with poorly controlled type 2 diabetes and obesity, with an acceptable saf
Two immunologically distinct, age-independent subtypes of new-onset type 1 diabetes demonstrate differing progression rates and therapeutic responses, offering a path toward tailored immunotherapies.
Emerging obesity pharmacotherapies targeting entero-pancreatic hormones deliver substantial weight loss and improve multiple obesity-related complications, heralding a treat-to-target paradigm in obesity management with personalized, compli
This article examines real-world data on low-dose antithymocyte globulin in type 1 diabetes, assessing beta-cell function via a novel C-peptide modified quantitative response (mQR). Findings suggest feasibility, safety, and potential clinic
Premeal insulin administration significantly lowers postprandial blood glucose and improves myocardial microvascular blood flow in young adults with type 1 diabetes, highlighting the importance of insulin timing for cardiovascular health.
This cohort study assesses the influence of hysterosalpingography with iodinated contrast on neurodevelopmental outcomes in children, revealing lower IQ scores in those conceived shortly after the procedure, warranting further investigation
Adjusting HbA1c thresholds for age improves risk prediction of type 1 diabetes progression in adults positive for islet autoantibodies, enhancing prevention strategies.
This study identifies plasma oxytocin as a superior preoperative biomarker compared to copeptin for early prediction of transient arginine vasopressin deficiency after transsphenoidal pituitary surgery, aiding in risk stratification and pos
Serial dried blood spot C-peptide sampling detects early β-cell preservation in new-onset type 1 diabetes more sensitively than urine C-peptide-to-creatinine ratio or mixed-meal tolerance test.
This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype
Prolonged mild sleep restriction of 1.5 hours per night over six weeks leads to modest weight gain, increased adiposity, and elevated leptin levels, highlighting the importance of adequate sleep in weight management and cardiometabolic risk
This case series reveals a high prevalence of uncontrolled hypertension among diabetic patients visiting ophthalmology clinics and highlights the importance of in-clinic blood pressure screening to identify and manage cardiovascular risk.
Reviewing ADA 2022 vs ACOG criteria and timing effects on postpartum OGTT in GDM women reveals inpatient testing increases screening uptake but varies in diabetes classification; highlights the need for consensus on test timing and interpre
This analysis reviews a pilot study evaluating high-dose levothyroxine treatment in adult RTHα patients, demonstrating safety, improved quality of life, and distinct metabolic alterations over three years.
This study reveals that endogenous glucose-dependent insulinotropic polypeptide (GIP) significantly enhances postprandial splanchnic blood flow in people with type 2 diabetes, influencing insulin secretion without affecting glucose levels.
Recent evidence indicates that advances in imaging and hormonal testing allow a reduction in the use of bilateral inferior petrosal sinus sampling without compromising diagnostic accuracy in Cushing’s disease.
The PRISM trial evaluated a precision medicine program using biogenetic markers and multidisciplinary care in Chinese young-onset diabetes patients, improving metabolic control and patient well-being but not reducing complications over thre
The HumAn-1 trial found no significant differences between insulin glargine and human isophane insulin in hypoglycemia risk or glucose control in young T1D patients in low-resource settings, underscoring accessibility over insulin type in t
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