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Harnessing Real-World Evidence to Optimize GLP-1-Based Therapies: Insights from a NIDDK Workshop
Diabetes & EndocrinologydiabetesGLP-1 receptor agonists

Harnessing Real-World Evidence to Optimize GLP-1-Based Therapies: Insights from a NIDDK Workshop

By MedXY|Jul 7, 2026

A NIDDK workshop highlighted the crucial role of real-world evidence in addressing gaps about GLP-1 receptor agonists’ safety, effectiveness, adherence, and economic impact to improve clinical and regulatory decision-making.

Development and Validation of a Noninvasive Score for At-Risk Metabolic Dysfunction-Associated Steatohepatitis in Individuals with Obesity Undergoing Bariatric Surgery
Diabetes & Endocrinologybariatric surgeryliver disease

Development and Validation of a Noninvasive Score for At-Risk Metabolic Dysfunction-Associated Steatohepatitis in Individuals with Obesity Undergoing Bariatric Surgery

By MedXY|Jul 5, 2026

Researchers developed and validated the FMO score, a noninvasive, cost-effective tool to identify at-risk metabolic dysfunction-associated steatohepatitis (MASH) in obese patients, showing strong predictive performance across multiple inter

Baseline and Longitudinal Joint Associations of Alcohol Consumption and Obesity with Diabetes Risk: Evaluating Multiplicative and Additive Interactions
Diabetes & EndocrinologyAlcohol Consumptiondiabetes risk

Baseline and Longitudinal Joint Associations of Alcohol Consumption and Obesity with Diabetes Risk: Evaluating Multiplicative and Additive Interactions

By MedXY|Jul 4, 2026

This study examines how obesity and alcohol consumption jointly impact diabetes risk over time in an Asian cohort, highlighting differences in interaction measures and implications for diabetes prevention.

Pathophysiology-Based Classification of Male Infertility: Transforming Diagnosis and Treatment Through Comprehensive Phenotyping
Diabetes & Endocrinologyendocrine assessmentpathophysiology

Pathophysiology-Based Classification of Male Infertility: Transforming Diagnosis and Treatment Through Comprehensive Phenotyping

By MedXY|Jul 4, 2026

This study of 800 men with infertility demonstrates that a detailed pathophysiology-based classification reduces idiopathic cases and identifies distinct endocrine profiles, enabling targeted management.

Declining Trends in Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Youth with Type 1 Diabetes Over Two Decades
Diabetes & Endocrinologycontinuous glucose monitoringimpaired awareness of hypoglycemia

Declining Trends in Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Youth with Type 1 Diabetes Over Two Decades

By MedXY|Jul 4, 2026

A population-based study reveals a significant reduction in impaired awareness of hypoglycemia and severe hypoglycemia in youth with type 1 diabetes from 2002 to 2024, indicating substantial progress in diabetes care and the ongoing need fo

Global Insights into MASLD: Predictors of Fibrosis, Clinical Events, and Mortality from the Global-MASLD Study
Diabetes & EndocrinologyfibrosisMASLD

Global Insights into MASLD: Predictors of Fibrosis, Clinical Events, and Mortality from the Global-MASLD Study

By MedXY|Jul 3, 2026

The Global-MASLD study identifies key predictors of advanced fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease, highlighting the prognostic value of noninvasive fibrosis markers across diverse populations.

Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study
Diabetes & Endocrinologydose-responseHypothyroidism

Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study

By MedXY|Jul 3, 2026

This real-world study demonstrates a dose-dependent increase in suboptimal thyroid hormone control among adults treated with levothyroxine, emphasizing the need for enhanced TSH monitoring in patients on higher doses.

Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes: A Comprehensive Review
Clinical UpdatesAdrenal Venous Samplingprimary aldosteronism

Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes: A Comprehensive Review

By MedXY|Jul 3, 2026

This review synthesizes evidence linking the 2025 Primary Aldosteronism Severity Classification (PASC) with adrenal venous sampling (AVS) lateralization and treatment outcomes, highlighting its potential to enhance precision in PA managemen

Evaluating Sleep Optimization for Glycemic Control in Adults with Type 1 Diabetes: Insights from a Randomized Controlled Trial
Diabetes & EndocrinologyGlycemic Controlrandomized controlled trial

Evaluating Sleep Optimization for Glycemic Control in Adults with Type 1 Diabetes: Insights from a Randomized Controlled Trial

By MedXY|Jul 3, 2026

A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.

Ultra-Thin Sirolimus-Eluting Stents Show Noninferiority to Everolimus-Eluting Stents in Diabetic Multivessel CAD: Insights from TUXEDO-2 Trial
Cardiologycoronary artery diseaseDiabetes Mellitus

Ultra-Thin Sirolimus-Eluting Stents Show Noninferiority to Everolimus-Eluting Stents in Diabetic Multivessel CAD: Insights from TUXEDO-2 Trial

By MedXY|Jul 2, 2026

The TUXEDO-2 trial demonstrated that ultra-thin strut biodegradable polymer sirolimus-eluting stents are noninferior to durable polymer everolimus-eluting stents in diabetic patients with multivessel coronary artery disease at 1-year follow

Enhancing Preventive Screening Uptake: EHR Portal Messages Boost Mammography Rates
Diabetes & EndocrinologyElectronic Health RecordsMammography Screening

Enhancing Preventive Screening Uptake: EHR Portal Messages Boost Mammography Rates

By MedXY|Jul 2, 2026

Iterative redesign of electronic health record (EHR) portal reminders significantly improved mammography screening adherence in an outpatient setting, demonstrating the value of concise messages with scheduling links, while retinal and HbA1

Quantitative Autofluorescence Index Enhances Intraoperative Differentiation of Normal and Pathologic Parathyroid Glands
Diabetes & Endocrinologyautofluorescencehyperparathyroidism

Quantitative Autofluorescence Index Enhances Intraoperative Differentiation of Normal and Pathologic Parathyroid Glands

By MedXY|Jul 1, 2026

Near-infrared autofluorescence heterogeneity measurement provides a real-time, quantitative tool during parathyroidectomy to distinguish hyperfunctional parathyroid glands from normal tissue, aiding surgical precision and potentially improv

Stimulating Thyrotropin Receptor Antibodies Amplify Fibroblast Expression of TSH and IGF-1 Receptors: Insights into Thyroid Eye Disease Pathogenesis
Diabetes & Endocrinologyautoantibodiesfibroblasts

Stimulating Thyrotropin Receptor Antibodies Amplify Fibroblast Expression of TSH and IGF-1 Receptors: Insights into Thyroid Eye Disease Pathogenesis

By MedXY|Jul 1, 2026

Stimulating TSH receptor antibodies enhance expression of TSHR and IGF-1R in fibroblasts via receptor recycling, elucidating mechanisms underlying thyroid eye disease and identifying potential therapeutic targets.

Continuous Glucose Monitoring-Derived Time in Range Predicts Longitudinal Changes in Arterial Stiffness in Type 2 Diabetes
Cardiologycontinuous glucose monitoringpulse wave velocity

Continuous Glucose Monitoring-Derived Time in Range Predicts Longitudinal Changes in Arterial Stiffness in Type 2 Diabetes

By MedXY|Jul 1, 2026

This study demonstrates that continuous glucose monitoring-derived time in range (TIR) is independently associated with progression of arterial stiffness in type 2 diabetes, highlighting TIR as a valuable metric beyond HbA1c for cardiovascu

Continuous Glucose Monitoring and Survival Benefits in Diabetic Veterans on Dialysis: Insights from a Nationwide Cohort
Diabetes & Endocrinologycontinuous glucose monitoringdiabetes

Continuous Glucose Monitoring and Survival Benefits in Diabetic Veterans on Dialysis: Insights from a Nationwide Cohort

By MedXY|Jul 1, 2026

Among U.S. veterans with diabetes on dialysis, continuous glucose monitoring (CGM) use was associated with significantly lower mortality risk compared to non-CGM use, highlighting CGM’s potential to improve survival in this high-risk

Expanding Technology-Enabled, Nurse-Delivered Chronic Disease Care: A Pragmatic, Randomized, Effectiveness-Implementation Trial
Diabetes & Endocrinologychronic diseasediabetes management

Expanding Technology-Enabled, Nurse-Delivered Chronic Disease Care: A Pragmatic, Randomized, Effectiveness-Implementation Trial

By MedXY|Jun 30, 2026

This study evaluates comprehensive nurse-led telehealth for uncontrolled type 2 diabetes and hypertension in a fee-for-service setting, finding limited improvement in HbA1c but identifying key barriers to implementation.

Erythrocytosis in Advanced Thyroid Cancer Therapy: Emerging Safety Concerns with Targeted Agents
Diabetes & EndocrinologyerythrocytosisRET inhibitors

Erythrocytosis in Advanced Thyroid Cancer Therapy: Emerging Safety Concerns with Targeted Agents

By MedXY|Jun 28, 2026

Erythrocytosis is an underreported hematologic side effect of targeted therapies in advanced thyroid cancers, notably RET inhibitors, occurring early and recurrently without impacting survival outcomes but correlating with disease control r

Preservation of Islet Function and Glycaemic Control After Total Pancreatectomy with Islet Autotransplantation: Insights From Continuous Glucose Monitoring
Diabetes & Endocrinologycontinuous glucose monitoringglycaemic control

Preservation of Islet Function and Glycaemic Control After Total Pancreatectomy with Islet Autotransplantation: Insights From Continuous Glucose Monitoring

By MedXY|Jun 28, 2026

This study demonstrates that nearly half of islet secretory function is preserved following total pancreatectomy with islet autotransplantation (TPIAT), independent of preoperative glycaemic status or prior pancreatic surgery. Continuous gl

Personalizing Osteoporosis Treatment: Integrating Pharmacotherapy with Patient-Centered Lifestyle Strategies
Diabetes & EndocrinologyShared decision makingosteoporosis

Personalizing Osteoporosis Treatment: Integrating Pharmacotherapy with Patient-Centered Lifestyle Strategies

By MedXY|Aug 18, 2026

This article explores personalized osteoporosis management, combining evidence-based pharmacologic therapies with individualized lifestyle and nutrition guidance, to improve patient outcomes through shared decision making.

Streamlining Identification of Ketosis-Prone Diabetes in Youth Using PEPPER: Advancing Atypical Diabetes Discovery
Diabetes & Endocrinologyatypical diabetesdiabetes screening

Streamlining Identification of Ketosis-Prone Diabetes in Youth Using PEPPER: Advancing Atypical Diabetes Discovery

By MedXY|Jun 28, 2026

The novel Python-based tool PEPPER enhances electronic medical record searches, efficiently identifying youth with ketosis-prone diabetes, and dramatically reducing manual chart review time without compromising accuracy.

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