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Systemic IL-6 inhibitors are linked to significantly reduced risks of diabetic retinopathy development, progression, and vision-threatening complications, suggesting therapeutic potential for diabetic eye disease.
Elevated maternal third-trimester TRAb levels in Graves’ disease are linked to neonatal thyroid dysfunction and impaired neurodevelopment at 24 months, independent of neonatal thyroid status, highlighting the need for prenatal monitor
Polygenic scores can predict type 1 diabetes risk after gestational diabetes, especially when combined with clinical factors, but show limited utility for type 2 diabetes prediction.
Partial lipodystrophy (PLD) often mimics Cushing’s syndrome (CS), complicating diagnosis. This study reveals overlapping features, limitations of CS clinical scores in PLD, and underscores the need for careful differential diagnosis t
Suspension of prior authorization requirements led to increased access to CGM and insulin pumps and significant HbA1c improvement in type 1 diabetes patients in a safety net clinic, highlighting benefits of reducing administrative barriers.
This study demonstrates that a telehealth-supported community health worker program with structured feedback loops significantly improves diabetes control and care adherence in low-income Hispanic adults.
A large Swedish cohort study assesses whether glucagon-like peptide-1 receptor agonists increase the risk of anterior ischemic optic neuropathy in type 2 diabetes. Although a borderline elevated relative risk was observed, absolute incidenc
A nationwide cohort study reveals that two-thirds of patients with primary hyperparathyroidism exhibit end-organ damage at diagnosis or during follow-up, yet few receive parathyroidectomy, underscoring missed opportunities to reduce morbidi
This mediation analysis of a phase 2 MASH trial reveals that survodutide improves liver inflammation and fibrosis predominantly through weight-independent mechanisms, highlighting a potential direct hepatic effect beyond weight reduction.
This study reveals that Asian Indians with prediabetes or type 2 diabetes show significantly higher liver and abdominal fat despite similar BMI, highlighting liver fat’s key role in dysglycaemia and the importance of early interventio
A phase 3 trial demonstrates that once-weekly somapacitan is non-inferior to daily growth hormone injections in promoting linear growth in girls with Turner syndrome, offering a promising alternative with comparable safety and efficacy prof
Melatonin impairs glucose tolerance and early insulin secretion, particularly in carriers of the MTNR1B diabetes risk allele, revealing critical mechanisms linking melatonin signaling to diabetes susceptibility and highlighting the need for
A large study in veterans with type 2 diabetes found that adding GLP-1 receptor agonists to basal insulin did not improve insulin discontinuation rates compared to SGLT-2 inhibitors or DPP-4 inhibitors over three years.
This article examines factors influencing the one-year success rate of DMEK in treating corneal endothelial dysfunction, highlighting the impact of operative complications and donor-recipient variables based on findings from the Diabetes En
A large-scale proteomic study identified distinct MASLD subtypes influenced by sex differences and developed a four-protein score predicting all-cause mortality, advancing personalized risk assessment beyond traditional liver-centric models
This retrospective study assesses the efficacy and safety of pemetrexed, alone or combined with carboplatin, as salvage therapy for advanced thyroid cancer, showing promising response rates comparable to current second-line treatments.
This study demonstrates that dapagliflozin does not impair LDL catabolism but favorably shifts VLDL1 and VLDL2 catabolism toward normal physiology in type 2 diabetes, potentially contributing to reduced atherosclerosis risk.
A 2022 nationwide study shows insulin pump therapy in adults with type 1 diabetes is associated with significantly lower 30-day readmissions and reduced in-hospital mortality compared to injectable insulin alone.
Common bedside tests for peripheral arterial disease in diabetic patients show poor sensitivity, challenging their clinical reliability compared to advanced imaging modalities.
A nationwide cohort study found that SGLT2 inhibitor initiation was associated with a 27% lower risk of incident lung cancer in patients with COPD and type 2 diabetes compared with sulfonylureas.
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