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Combination Therapy with GLP-1 Receptor Agonists and SGLT-2 Inhibitors Reduces Liver and Cardiovascular Risks in MASLD and Type 2 Diabetes

MedXY Editorial Team•Apr 25, 2026•Diabetes & Endocrinology
GLP-1 receptor agonistMASLDSGLT-2 inhibitortype 2 diabetes

Highlights

The combination of GLP-1 receptor agonists and SGLT-2 inhibitors reduces the risk of major adverse liver outcomes by 39% compared to GLP-1 receptor agonists alone and by 43% compared to SGLT-2 inhibitors alone. Additionally, the combination therapy lowers the risk of major adverse cardiovascular events by 35% and 20%, respectively.

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