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Mechanical ventilation during surgery induces neutrophil extracellular vesicles that propagate lung inflammation and contribute to postoperative pulmonary complications, highlighting potential new biomarkers and therapeutic targets.
This multi-institutional qualitative study explores specialty palliative care clinicians’ perspectives on optimizing their role in the ICU, highlighting strategic consultation timing, shared understanding with intensivists, and embedd
This study evaluates ECMO as a standalone respiratory support in ARDS patients avoiding invasive mechanical ventilation, highlighting outcomes, strategy failures, and mortality implications.
This study investigates the association between continuation of non-full code status during surgery and early postoperative mortality, revealing higher mortality risk that aligns with clinical care decisions rather than missed rescue opport
This study evaluates respiratory support and mortality trends in Andes virus-induced hantavirus cardiopulmonary syndrome (HCPS) across Chile, highlighting increased mortality during the COVID-19 pandemic period and a high requirement for in
In penetrating liver trauma, angioembolization offers survival outcomes comparable to surgery but is linked to longer hospital and ICU stays, highlighting the need for strategic patient selection and multidisciplinary care integration.
This study explores how intensivists conceptualize appropriate goals of care and the influences of health system factors on decision-making for patients with chronic critical illness, emphasizing predictions about quality of life and functi
This retrospective cohort study explores how immigration status influences ICU admission rates and length of stay among ischemic stroke patients in Ontario, revealing longer ICU stays for immigrants despite similar admission rates compared
This study explores rehabilitation initiation, progression, and physical activity levels in adult ECMO patients, highlighting early active rehabilitation feasibility and varied activity trajectories based on clinical goals.
Longer hospital arrival times significantly increase both in-hospital and long-term mortality in cardiogenic shock, highlighting the urgent need for regional care coordination and early triage.
A Danish multicentre trial demonstrates that individualized, clinically guided antibiotic treatment lasting around 3 days is as safe as the standard 5-7 days in late-preterm and term neonates with culture-negative early-onset sepsis, signif
Late-onset sepsis (LOS) incidence among very preterm infants declined from 2010 to 2017 but has risen since, driven mainly by increasing infections from non-CoNS gram-positive bacteria and gram-negative pathogens, notably Staphylococcus aur
A pilot randomized trial comparing targeted temperature management at 35°C versus normothermia in intubated heatstroke patients showed no survival or neurological benefit from hypothermia but increased gastrointestinal injury and arrhythmia
A nationwide South Korean study reveals that longer hospital arrival times significantly increase both in-hospital and long-term mortality in patients with cardiogenic shock, emphasizing the need for improved regional healthcare coordinatio
Septic shock following allogeneic hematopoietic stem-cell transplantation has a high 90-day mortality rate of 63%, strongly influenced by illness severity, fungal infection, and neutropenia. Early aminoglycoside use shows complex associatio
The EVER trial examined if a structured early mobilization protocol improves functional outcomes in ventilated patients with sepsis or respiratory failure. Despite earlier and increased mobilization, no significant functional benefit was ob
Pediatric ICU admissions in the U.S. have increased significantly from 2001 to 2022, with rising complexity and costs, highlighting the need for expanded critical care resources and regionalized care.
This study reveals that acute hypoxemic respiratory failure (AHRF) affects half of ICU patients needing respiratory support, with severity linked to worse outcomes. Lung-protective ventilation is common, underscoring the need for standardiz
This review explores how the human microbiome influences management and outcomes in critically ill patients, emphasizing gastrointestinal microbial dynamics, disruption by critical illness and therapies, and emerging interventions to restor
The ENCHANTED trial post hoc analysis reveals body weight does not alter alteplase dose effectiveness in acute ischemic stroke, but low body weight independently predicts poorer outcomes without increased hemorrhagic risk.
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