Optimizing Intraoperative Blood Pressure in Hypertensive High-Risk Patients: Insights from the HISTAP Trial

Highlight

• Targeting a higher intraoperative mean arterial pressure (MAP ≥80 mmHg) in hypertensive high-risk patients significantly reduces postoperative major organ dysfunction compared to the standard target (MAP ≥65 mmHg).
• Reduction in acute kidney injury incidence accounts for much of the observed benefit in postoperative outcomes with higher MAP targeting.
• The HISTAP multicenter randomized trial provides high-level evidence to refine blood pressure management strategies during major abdominal surgery in older hypertensive patients.

Study Background