Clinical Metagenomics in Sepsis: Insights from the DigiSep Randomized Controlled Trial
clinical outcomeshealth-related quality of lifeHealthcare Costsmetagenomic next-generation sequencingsepsis
Highlight
- Adding metagenomic next-generation sequencing (mNGS) to standard microbiology did not significantly improve the primary DOOR/RADAR score at 28 days after sepsis onset.
- Secondary endpoints showed meaningful benefits with mNGS, including shorter mechanical ventilation duration and faster resolution of shock.
- Patients receiving mNGS-guided diagnostics experienced improved health-related quality of life at 90 days post-sepsis.
- Healthcare costs over 180 days did not increase with the addition of mNGS diagnostics.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.