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In a multicenter retrospective study, early mechanical thrombectomy within 12 hours of pulmonary embolism diagnosis improved pulmonary artery pressure reduction and reduced intubation, but did not significantly lower in-hospital mortality.
In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting ur
A multi-center study reveals that circulatory support escalation in cardiogenic shock is associated with higher mortality and complications, but certain patient factors can predict successful outcomes.
A prospective cohort study identifies biomarker signatures for host resistance, disease tolerance, and damage in sepsis, revealing associations with mortality and sepsis subtypes.
A structured exercise program combining mobility therapy and resistance training in ECMO patients proved feasible and safe, with longer session times correlating with better functional performance.
A multicenter study reveals that culturally and linguistically diverse patients with sepsis had lower in-hospital mortality and shorter ICU stays compared to non-CaLD patients, challenging prior assumptions about healthcare disparities.
A multicenter European cohort study demonstrates that antifungal treatment significantly reduces 60-day mortality in COVID-19-associated pulmonary aspergillosis (CAPA), particularly in immunocompromised patients. Key findings underscore the
A study finds that increased annual trauma patient volume per EMS clinician is associated with significantly reduced 6-hour and in-hospital mortality rates, highlighting the importance of experience in prehospital trauma care.
Early low-calorie and low-protein nutrition in critically ill patients with shock does not worsen renal outcomes compared to standard feeding, per NUTRIREA-3 post hoc analysis.
A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l
A large observational study reveals that cardiogenic shock patients receiving temporary mechanical circulatory support at regional referral centers before transfer to hub centers experience significantly higher device-related adverse events
The SHOSREB trial demonstrates that remimazolam besylate is non-inferior to propofol for short-term light sedation in mechanically ventilated ICU patients, with both agents achieving 97.5% successful sedation rates and comparable time withi
A landmark 20-year analysis of over 200,000 mechanically ventilated ARDS patients reveals a striking paradox—mortality declined during the ICD-9 era but increased after ICD-10 adoption, challenging assumptions about ARDS outcomes and highli
A prospective study highlights significant discrepancies between point-of-care and central laboratory sodium and potassium measurements in the ICU, revealing a 10.48 mmol/L limit of agreement for sodium and a widespread lack of physician aw
Expert consensus highlights a shift in shock treatment, emphasizing that standardized protocols must give way to personalized, physiology-driven bedside care to prevent iatrogenic injury and improve survival.
This review analyzes the analytical biases between direct and indirect potentiometry for sodium and potassium measurement in critical care, highlighting significant clinical classification discrepancies and a widespread lack of physician aw
A prospective cohort study demonstrates that antipsychotic use in critically ill patients is significantly associated with fewer catatonia-free days, suggesting that dopamine blockade may be a primary driver of catatonic syndromes in intens
This clinical analysis of 500 patients identifies heart failure and arrhythmias as the primary causes of SCAI Stage B shock. Key findings highlight acute kidney injury and diuretic resistance as significant predictors of clinical deteriorat
A large-scale trial in Brazilian ICUs found that daily chlorhexidine bathing did not lower overall nosocomial infection rates but significantly reduced multi-drug resistant pathogen isolation and the use of high-priority reserve antibiotics
This multi-center study demonstrates that serial monitoring of plasma GFAP and NfL biomarkers can detect acute brain injury in pediatric ECMO patients before imaging diagnosis, significantly correlating with long-term survival and functiona
