Critical Care
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227 articles · 20 / page
Lower-Intensity Anticoagulation During Venovenous ECMO: A Pilot RCT Shows Feasibility and a Signal Toward Less Bleeding
A 3-center randomized pilot trial found that randomized allocation to low- versus moderate-intensity anticoagulation during venovenous ECMO is feasible, with lower major bleeding rates in the low-intensity arm and no clear excess of thrombo
Higher Early IV Fluid Rates Tied to More SIRS but Lower BUN Rise in Acute Pancreatitis: Findings From an International Cohort Presented at ACG 2025
An international prospective cohort found that higher early IV fluid rates were associated with lower odds of BUN rise but higher odds of new or persistent SIRS at 6 and 24 hours after presentation, highlighting confounding issues and the n
Selective Decontamination of the Digestive Tract in ICU Ventilated Patients: Impact on Mortality and Microbial Ecology
A large international trial found that selective decontamination of the digestive tract (SDD) during mechanical ventilation did not reduce hospital mortality but decreased bloodstream infections and antibiotic-resistant organisms, with no c
Noninferiority of Deferring Early Arterial Catheterization in Shock Management: Insights from a Multicenter RCT
A large multicenter trial demonstrated that deferring early arterial catheter insertion in ICU patients with shock is noninferior to early invasive monitoring for 28-day mortality, with fewer catheter-related complications and comparable sa
RIPK3 as a Prognostic Biomarker in Acute Decompensation of Cirrhosis: Advancing Risk Stratification and Therapeutic Targeting
RIPK3-associated necroptosis critically drives organ failure and mortality in acute decompensation and ACLF, with its plasma levels robustly predicting outcomes and improving prognostic models to guide personalized therapies.
Innovative Extracorporeal Therapy Combining HLA-Depleted Liver Organoids and Granulocyte-Monocyte Apheresis for Reversal of Acute Liver Failure
The UTOpiA system, integrating HLA-depleted iPSC-derived liver organoids with granulocyte-monocyte apheresis, significantly improves survival and liver regeneration in acute-on-chronic and acute liver failure rat models, representing a prom
Evaluating the Cost-Effectiveness of Early In-Bed Cycling Plus Routine Physiotherapy in Mechanically Ventilated ICU Patients: Insights from the CYCLE Trial
This economic evaluation from the CYCLE randomized trial found no significant cost or quality-adjusted life-year benefit by adding early in-bed cycling to usual physiotherapy for ICU patients on mechanical ventilation, underscoring a need f
Surge in Invasive Streptococcus pyogenes Infections Among Children Post-COVID-19: Insights from a Spanish Nationwide Study
A Spanish multicenter study reveals a sharp rise in pediatric invasive group A streptococcal infections and severity after 2022, highlighting emm1 strain predominance and risk factors for critical illness and mortality.
Risk Factors and Epidemiological Trends in Severe Pediatric Invasive Group A Streptococcal Disease: Insights from the Netherlands 2015–2024
A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.
Epstein-Barr Virus and Pediatric Sepsis: Unraveling Links to Immune Dysregulation and Mortality
This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.
Reassessing the Safety of Peripheral Vasopressor Use in Early Sepsis: Evidence from a Large Prospective Cohort Study
This study evaluates factors influencing vasopressor route choice in sepsis and demonstrates low complication rates associated with peripheral administration, supporting its safety in early resuscitation.
Postoperative Vasopressor Use After Noncardiac Surgery: Patterns, Outcomes, and Clinical Implications from a Global Observational Study
An international study reveals that postoperative vasopressor infusions after noncardiac surgery vary widely across hospitals and are linked to higher mortality and complications, highlighting the need for optimized management strategies.
Evaluating CT Perfusion and Angiography as Ancillary Tests for Brain Death Diagnosis: Insights from a Multicenter Canadian Study
A large Canadian prospective study assessed brain CT perfusion and angiography for confirming death by neurologic criteria, highlighting high sensitivity but suboptimal specificity, emphasizing cautious use alongside clinical examination.
Optimizing Critical Care Outcomes: The Pivotal Role of Rehabilitation and Physiotherapy
This article reviews current evidence and clinical practices for physiotherapy in ICU settings, emphasizing benefits, safety, staffing challenges, and future directions in critical care rehabilitation.
Enhancing Surgical Patient Safety: Impact of the SIPS Handover System on Clinical Outcomes
The SIPS surgical handover system significantly improves handover quality, patient vital signs, and staff safety perceptions without prolonging meeting times, enhancing safety in emergency general surgery.
Advancing Early Pediatric Sepsis Detection: Machine Learning Models Predicting Onset Within 48 Hours
This study developed and validated machine learning models with high accuracy to predict early pediatric sepsis and septic shock within 48 hours using multisite electronic health record data in emergency departments.
Empowering Older Adults in Acute Care: Insights on Shared Decision Making for Treatment Escalation Planning
This qualitative UK study explores older patients’ perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical approaches
Proactive Versus Reactive Intraoperative Blood Pressure Management: Insights from the PRETREAT Randomized Clinical Trial
The PRETREAT trial found that proactive blood pressure management tailored by risk of intraoperative hypotension does not reduce postoperative functional disability compared to standard care in noncardiac surgery.
Individualized Perioperative Blood Pressure Management in Major Abdominal Surgery: Insights from the IMPROVE-multi Trial
The IMPROVE-multi randomized clinical trial found that tailoring perioperative blood pressure targets to individual preoperative nighttime MAP levels did not reduce postoperative organ injury or mortality compared to routine management in h
Clinical Decision Tool Integrating Decision Tree, Point-of-Care CRP Testing, and Safety Netting to Optimize Antibiotic Use in Acutely Ill Children: Evidence from the ARON Pragmatic Trial and Contextual Literature
The ARON trial demonstrated that a clinical decision tool combining decision tree, point-of-care CRP testing, and safety-netting advice safely reduces antibiotic prescribing in acutely ill children without delaying recovery or increasing he
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