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Choice of Vasopressor in Septic Shock: Does It Change Kidney Outcomes? A Critical Appraisal of the Evidence

MedXY Editorial Team•Nov 7, 2025•Critical Care
acute kidney injuryrenal outcomesseptic shockvasopressors

Highlight

– A systematic review of randomized trials (McDonald et al., 2025) found no conclusive benefit of any specific vasopressor on incidence of acute kidney injury (AKI) in septic shock.
– Reporting was heterogeneous: only 8/17 trials reported AKI incidence using KDIGO/AKIN or undefined criteria; RRT use was the most common renal outcome but inconsistently defined.
– Existing evidence is underpowered and methodologically limited; future trials should standardize renal endpoints (KDIGO/MAKE), target subgroups at high renal risk, and include longer-term kidney outcomes.

Background: clinical context and unmet need

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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