Critical Care
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Iloprost in Severe Septic Shock with Persistent Hypoperfusion: Insights from a Rigorous Randomized Trial
A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.
Normosol-R versus Lactated Ringers in Critical Care: Evaluating Balanced Crystalloids for Optimal Patient Outcomes
A randomized trial evaluating Normosol-R versus lactated Ringers in critically ill adults found no significant difference in acid-base balance, kidney replacement therapy rates, or 30-day mortality, supporting comparable efficacy between th
UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit
The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.
Assessing the Impact of a Ketogenic Diet in Critically Ill Sepsis Patients: An Open-Label Randomized Controlled Trial
This trial demonstrates that a ketogenic diet safely induces stable ketosis in sepsis patients, improving metabolic parameters and immune regulation without adverse effects, suggesting potential benefits for sepsis-related organ dysfunction
Intensive Nurse Home Visiting and Early Childhood Outcomes: A Randomized Clinical Trial
A randomized trial assessing the impact of Nurse-Family Partnership home visits on child health and utilization over two years found no significant reduction in adverse outcomes but some decrease in emergency department use.
Memorize the “Anaphylactic Shock” Emergency Resuscitation Sequence to Easily Handle Critical Emergency Cases!
Severe allergic reaction refers to a sudden, severe, potentially life-threatening systemic allergic reaction in the...
Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation
A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.
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