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Acoramidis demonstrates substantial benefits in heart failure-related health status among ATTR-CM patients, significantly improving patient-reported outcomes and supporting its role in modifying disease trajectory.
JCAD, a junctional protein, independently predicts major adverse cardiovascular events (MACE) in acute coronary syndrome (ACS) patients with residual lipid and inflammatory risks, suggesting a key role in coagulation and fibrinolysis and a
This article reviews the accelerated evidence generation for anticoagulation in noncritically ill COVID-19 patients, highlighting how coordinated trials and data sharing influenced clinical guidelines and patient outcomes during the pandemi
A machine learning model using electronic health records effectively identifies patients at high risk of atrial fibrillation, enabling targeted screening and early diagnosis to prevent stroke.
In a randomized trial among Navajo patients with heart failure, an 8-week culturally tailored meal program reduced all-cause hospitalization or ED visits by 28% compared with usual dietary advice, with improvements in quality of life and food security.
In the EARLY TAVR registry, treadmill stress testing was safe and unmasked symptoms in 15% of asymptomatic severe aortic stenosis patients. Yet 20% of those with an indication for prompt aortic valve replacement remained untreated after one year.
A predefined subanalysis of EAST-AFNET 4 shows early rhythm control safely reduces cardiovascular events in recently diagnosed AF patients with CKD, with a trend toward greater benefit in this high-risk group.
A meta-analysis of 23 observational studies shows higher MIND diet adherence is associated with a 55% lower cancer risk and reduced all-cause and CVD mortality. Separately, the MIND trial now provides genetic data to explore precision nutrition for cognitive decline.
Severe hypertriglyceridemia (TG >500 mg/dL) affects ~1 in 88 adults and carries risks of pancreatitis and cardiovascular disease. Novel therapies targeting apoC-III, notably plozasiran siRNA, demonstrate dramatic TG reductions and pancreatitis risk mitigation. Pediatric management remains guideline-limited. Standardization of definitions is needed.
A study of 305 individuals with type 2 diabetes found that blood-based DNA methylation models predicted 5-year major adverse cardiovascular events with high accuracy, suggesting potential for improved risk stratification.
A cluster RCT in Brazil found that a digitally enabled quality improvement intervention modestly reduced LDL-C and increased treatment intensification in ASCVD patients, but a care gap remained.
Single-cell analysis of carotid plaques identifies four macrophage subtypes, with lipid-associated macrophage markers PLIN2 and TREM1 predicting secondary major adverse cardiovascular events after endarterectomy.
Highlight 1. Chest wall thickness (CWT) varies significantly between anatomical sites used for needle thoracostomy…
This review synthesizes contemporary evidence on initiation, adherence, and persistence of guideline-directed medical therapy after heart failure hospitalization, highlighting critical gaps and strategies to improve long-term patient outcom
This review synthesizes key findings evaluating olorofim’s clinical effectiveness and safety in patients with refractory disseminated coccidioidomycosis, emphasizing its potential role amid limited treatment options.
A translational study combining human heart tissue, CRISPR mouse models, and multi-omics reveals that loss of the ACL enzyme alters cardiac metabolism, promoting left ventricular dysfunction; restoring citrate flux via IDH1 deletion improves function in mice.
This analysis of the SOUL trial shows oral semaglutide reduces major cardiovascular events, with greater benefits linked to higher baseline HbA1c and larger HbA1c reductions, while BMI changes did not significantly affect outcomes.
GLP-1 receptor agonists significantly reduce atherosclerosis progression, inflammatory biomarkers, and cardiovascular events independent of glycaemic control and obesity status, evidenced by robust preclinical and large-scale clinical data.
Medically tailored groceries modestly improve HbA1c and significantly enhance food and nutrition security among Medicaid-insured adults with type 2 diabetes, supporting ‘Food Is Medicine’ strategies in chronic disease management
This study introduces and validates a simplified machine learning-based equation for estimating LDL cholesterol, showing comparable accuracy to the original Martin-Hopkins method and improved ease of use.
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