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Risk-weighted apoB (RW-apoB) integrates LDL, TRL/remnants, and Lp(a) atherogenicity to improve coronary heart disease risk prediction, outperforming conventional lipid biomarkers like apoB and LDL-C in multiple population cohorts including
This study reveals that 21% of asymptomatic patients with mild HCM develop major adverse cardiovascular events over 7 years, highlighting key predictors such as age, symptom progression, and cardiac remodeling markers that inform management
Obicetrapib significantly lowers lipoprotein(a), LDL cholesterol, and apolipoprotein B in high cardiovascular risk patients, offering a promising addition to lipid-lowering therapies, especially for patients with mild to moderate Lp(a) elev
The SELUTION4ISR trial demonstrates that sirolimus-eluting balloons are a safe and effective noninferior alternative to standard care, including repeat drug-eluting stents, for treating coronary in-stent restenosis at 1 year.
Unsupervised clustering of echocardiographic and hemodynamic data in sepsis reveals four distinct cardiovascular subphenotypes, each with unique mortality risks and responses to treatment, enabling personalized shock management strategies.
A two-day stay at 2500 m altitude increases right ventricular afterload and impairs ventricular-arterial coupling but maintains oxygen delivery in stable pulmonary vascular disease patients.
Menaquinone-7 (MK-7) supplementation over two years significantly slows progression of coronary artery calcification (CAC) in symptomatic coronary artery disease patients, with favorable safety and potential implications for plaque stabiliz
The InEurHeart trial demonstrates that computed tomography-guided ventricular tachycardia ablation significantly reduces procedure duration while maintaining safety and efficacy compared to conventional methods in patients with ischemic car
Radiomic analysis of epicardial adipose tissue from routine cardiac CT scans enables robust, noninvasive early prediction of heart failure risk, enhancing conventional models and supporting precision prevention strategies.
Cerebral small vessel disease (SVD) significantly contributes to functional decline independently of bleeding or ischemic events during antithrombotic therapy, underscoring the need for targeted management strategies to address SVD burden i
Acoramidis stabilizes transthyretin and shows kidney-protective effects in transthyretin amyloid cardiomyopathy by reducing eGFR decline and albuminuria, with an initial reversible dip in kidney function associated with improved clinical ou
This review synthesizes evidence demonstrating that implementing full quadruple GDMT (ARNI, β-blockers, MRAs, SGLT2i) in HFrEF reduces hospitalization risks and healthcare costs, often yielding net savings despite medication expenses.
A novel risk score incorporating COPD and graded renal dysfunction improves prediction of one-year mortality post-TAVI, showing excellent internal validity but requiring external validation before clinical use.
In frail elderly Asian AF patients stable on warfarin, transitioning to DOACs increased risks of bleeding, thromboembolic events, and mortality, emphasizing cautious individualized management.
The TUXEDO-2 trial demonstrated that ultra-thin strut biodegradable polymer sirolimus-eluting stents are noninferior to durable polymer everolimus-eluting stents in diabetic patients with multivessel coronary artery disease at 1-year follow
This study explores how various social adversity domains affect mortality and rehospitalization risks in HIV-positive patients with heart failure, underscoring the importance of holistic social assessments for improving outcomes.
Emerging evidence indicates that radiation dose to the left anterior descending coronary artery better predicts cardiac events than whole-heart dose in breast radiotherapy, emphasizing the importance of LAD-based planning to reduce long-ter
This study demonstrates that continuous glucose monitoring-derived time in range (TIR) is independently associated with progression of arterial stiffness in type 2 diabetes, highlighting TIR as a valuable metric beyond HbA1c for cardiovascu
This review synthesizes evidence from a pioneering nonrandomized trial demonstrating that intravenous AAVrh.10hFXN gene therapy is safe and may improve cardiac outcomes in Friedreich ataxia cardiomyopathy, highlighting translational advance
Spatial proteomics reveals immune and metabolic heterogeneity in cardiac sarcoidosis, identifying new diagnostic protein signatures beyond granulomatous lesions.
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