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Systemic Treatment Remains Underused in Older Adults With Metastatic Non-Small Cell Lung Cancer
A large SEER-Medicare study found that fewer than half of older adults with metastatic NSCLC received systemic therapy, with only modest improvement from 2006 to 2021. Specialist referral and biomarker testing were strongly linked to treatm
Obesity Counseling Is Still Missed in Most US Office Visits, With Older Adults Least Likely to Receive Advice
A national analysis of US office visits found that obesity counseling remains uncommon, with only 40.1% of visits including any counseling and 12.2% including weight, diet, and exercise advice together.
Low-Dose Aspirin’s Pregnancy Benefit Appears Unchanged by Start Time or Adherence in a Large Multicentre Post Hoc Trial Analysis
In this post hoc analysis of a large randomized pregnancy trial, aspirin’s effects on preterm birth and perinatal mortality were not meaningfully modified by gestational age at initiation or measured adherence.
Weak Grip, Slow Walking Pace, and Sarcopenia Signal Higher Risk of Incident Stroke and Worse Poststroke Survival in UK Biobank
In nearly 483,000 UK Biobank participants, sarcopenia, low grip strength, and slow walking pace were associated with higher risks of incident stroke and poorer survival after stroke.
Multi-ancestry Polygenic Risk Scores Substantially Improve Type 2 Diabetes Risk Prediction Across Diverse Populations
A large multi-ancestry study shows that publicly available polygenic risk scores improve prediction of type 2 diabetes onset and selected microvascular complications across major global ancestry groups.
Household Income Decline and Job Loss Among Survivors of Critical Illness: A Nationwide Cohort Study
A large South Korean study reveals critical illness survivors face severe socioeconomic consequences, with 27.6% experiencing income decline and 12.3% job loss within a year, disproportionately affecting high-income households despite unive
Ethnicity Influences Relapse-Free Survival in Immune-Mediated Thrombotic Thrombocytopenic Purpura
A French study reveals African ancestry significantly increases relapse risk in iTTP patients treated with rituximab. Key risk factors include male sex and prior relapses, with implications for personalized monitoring strategies.
Whole-Genome Sequencing Suggests Casual Community Contact Drives Much of Drug-Resistant Tuberculosis Transmission in Durban
A molecular epidemiology study in Durban found that casual community contact, not only household or named contacts, accounted for a substantial share of drug-resistant tuberculosis transmission.
Most Patients Reach 20/40 After Cataract Surgery, but the Current MIPS Success Metric May Misclassify Quality and Exclude Nearly Half of Cases
A large multicenter study found that MIPS measure 191 captures high cataract surgery success rates but excludes many patients and may require case-mix adjustment to support fair surgeon comparisons.
Large Multi-Center EMR Cohort Suggests NSAID Exposure Is Associated With Lower Future Risk of Age-Related Macular Degeneration
In a large TriNetX retrospective cohort, prescribed NSAID use was associated with a lower subsequent risk of AMD, including both non-exudative and exudative disease, though residual confounding limits causal inference.
HPV Self-Sampling May Expand Cervical Cancer Screening Access for Transmasculine and Nonbinary Patients
A narrative review suggests HPV self-sampling is acceptable and potentially practice-changing for transmasculine and nonbinary people who are often underscreened for cervical cancer.
Type 1 Diabetes in Sweden Clusters in Rural Areas, With Early-Childhood Geography Showing the Strongest Signal
A nationwide Swedish cohort study found marked geographic variation in type 1 diabetes incidence, with the strongest clustering linked to residential location during the first 5 years of life and higher risk in rural, forested, and agricult
Education and Neighborhood Resources Explain Much of the Racial and Ethnic Gap in Timely Dementia Diagnosis
Among older U.S. adults with dementia, non-Hispanic Black and Hispanic individuals were significantly less likely than non-Hispanic White individuals to receive a timely diagnosis, with education and neighborhood affluence explaining much o
Medicare’s Oncology Care Model Did Not Increase Systemic Therapy Starts and Was Linked to Lower Use in Poor-Prognosis Cancer
A matched difference-in-differences study found that the Oncology Care Model did not increase systemic therapy initiation overall and was associated with lower treatment initiation and lower spending in poor-prognosis cancers.
“Never More Than 15 Feet From the Respirator”: Housestaff Research During the 1955 Boston Polio Epidemic
During Boston’s devastating 1955 polio epidemic, Massachusetts General Hospital trainees conducted groundbreaking patient research while providing round-the-clock care in iron lung wards – a striking contrast to trainee roles during COVID-1
Ergonomic Strain Is Common in Otolaryngology Surgery, With Pain Rising as Cases Become More Difficult and Prolonged
A prospective study found frequent medium-to-high ergonomic risk and measurable postoperative pain among otolaryngology surgeons, highlighting modifiable occupational hazards in routine head and neck surgery.
Laparoscopic Groin Hernia Repair Showed the Lowest Long-Term Operative Recurrence in Medicare Patients, While Robotic Use Expanded Without Clear Recurrence Benefit
A large Medicare cohort found low 5-year operative recurrence after groin hernia repair overall, with laparoscopic repair showing the lowest adjusted risk and robotic-assisted repair offering no recurrence advantage despite rapid uptake.
Status Epilepticus Mortality in U.S. Adults Is Rising, With the Highest Burden in Older Adults, Men, Non-Hispanic Black Populations, and the South
A U.S. mortality analysis from 1999 to 2020 found increasing deaths from status epilepticus after 2007, with marked disparities by age, sex, race/ethnicity, and region.
Quality of Breast Cancer Care and Patient Survival Show No Link to Hospital Safety-Net Burden
A major study reveals that safety-net hospitals—serving vulnerable Medicaid and uninsured patients—deliver breast cancer care and survival outcomes on par with other hospitals, challenging assumptions about quality disparities in resource-c
Commercially Insured Patients Wait a Median of 25 Days for New Neurology Care, with Regional and Plan-Based Differences
Among 114,034 commercially insured patients, the median time to a new neurology visit was 25 days. Waits varied by sex, diagnosis, region, and plan type, while neurologist density showed no association with access.
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