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Academia Is a Very Unforgiving Space: A Qualitative Study of Challenges Faced by Under-represented Scholars in Biomedical Research
This qualitative study explores systemic barriers faced by underrepresented scholars in biomedical research, revealing challenges in academic culture, external pressures, and strategies for resilience through interviews with 78 early-career
Global Disparities in CAR T-Cell Access: HTA Analysis Reveals Only Half of G20 Countries Recommend Reimbursement
A cross-sectional analysis of health technology assessments across G20 nations reveals significant disparities in access to CAR T-cell therapies, with only 48% of approved indications recommended for reimbursement and a median 1.54-year del
Money Talks: How Pharmaceutical Industry Payments Influence MS Doctors to Prescribe Costlier Brand-Name Drugs Over Generics
A new study reveals that neurologists receiving $1,000 or more from drug manufacturers were over 4 times more likely to prescribe expensive brand-name MS medications when generics were available, driving up costs for patients and the health
Earlier Menopause Linked to Accelerated Multimorbidity Progression: UK Biobank Multi-State Analysis Reveals Critical Windows for Preventive Intervention
A large UK Biobank cohort study of 121,017 postmenopausal women reveals that earlier menopause significantly increases risks of multimorbidity progression, with women experiencing premature menopause facing 32% higher risk of developing fir
Beyond Communication: Language Barriers Linked to Higher Hospital Utilization at End-of-Life in Dementia
A retrospective cohort study reveals that dementia patients with preferred language other than English are more likely to have documented goals-of-care discussions yet experience significantly higher hospital-based healthcare utilization ne
Beyond Shared Identity: How Physician-Patient Racial Concordance Modulates Inpatient Advance Care Planning
A large-scale study of 390,000 hospitalizations reveals that while racial concordance modestly increases advance care planning (ACP) discussions, physician race and systemic quality initiatives play significant, nuanced roles in end-of-life
Primary Cesarean Delivery Linked to Decreased Subsequent Fertility and Increased ART Utilization: A Decadal Population Study
A large-scale retrospective cohort study involving nearly 300,000 women demonstrates that undergoing a cesarean delivery for a first birth is associated with an 11% lower likelihood of a second live birth and a 28% higher reliance on assist
Patient Engagement and the Reality of Home Blood Pressure Monitoring: New Research Perspectives
This study examines patient engagement with home blood pressure monitoring (HBPM) in a remote management program, revealing that accessibility and support do not always guarantee high patient compliance.
Bridging the Evidence Gap: African Representation in Global Randomized Controlled Trials (2019–2024)
This systematic review analyzes the profound underrepresentation of African populations in high-impact clinical trials, revealing a stark disparity in cardiovascular and general medical research that limits the global applicability of evide
Is Semaglutide Worth the Cost? Evaluating the Economic Reality of GLP-1s for Heart Disease Prevention
A comprehensive simulation study evaluates the cost-effectiveness of semaglutide for secondary cardiovascular prevention in US adults without diabetes, finding significant health benefits but highlighting the need for price reductions to en
Ethnic Minority Patients with Heart Failure in England Achieve Superior Survival: The Crucial Role of Specialist Care and Medication Adherence
A large-scale analysis of 239,890 patients in England reveals that Black, Asian, and mixed-ethnicity patients hospitalized for heart failure have significantly lower mortality rates than White patients, largely due to better pharmacological
Telemedicine as a Strategic Tool for Post-Emergency Department Care Transitions: Analysis of Utilization and Safety, 2020–2022
This evidence-based review analyzes the adoption and clinical outcomes of telemedicine for post-ED follow-up, highlighting that while utilization is currently low (2.8%), it offers a safe alternative to in-person care without increasing ret
Post-Pandemic Firearm Acquisition and Household Exposure: Insights from the 2024 National Firearms Survey
The 2024 National Firearms Survey reveals that 29.8 million US adults acquired firearms between 2021 and 2024. This trend introduced 11.2 million new owners, significantly increasing household exposure for millions of adults and children, r
The Persistence of Ophthalmic Scarcity: A 23-Year Longitudinal Analysis of Drug Shortages in the United States
This review analyzes ophthalmic drug shortages from 2001 to 2024, revealing that eye medications face longer shortage durations than other drug classes, significantly influenced by patent status and manufacturing transparency.
Strengthening the Patient Voice: New Guidance for Qualitative Research in Internal Medicine
This article outlines new expert consensus on conducting rigorous qualitative research in internal medicine, providing a roadmap for investigators to move beyond numbers and capture the human experience of healthcare through methods like in
Beyond Aging: Traumatic Brain Injury and Depression Emerge as Leading Predictors of Dementia in US Veterans
A large-scale analysis of the VA Million Veteran Program reveals that TBI, depression, and specific military environmental exposures significantly elevate the 10-year risk of Alzheimer’s and related dementias, highlighting critical targets
Severe Obesity Triples Heart Failure Risk: New Insights from the Cross-Cohort Collaboration
A massive study of nearly 290,000 participants reveals that severe obesity (BMI ≥40) triples the risk of heart failure and nearly triples the risk of atrial fibrillation, with significant sex-based differences in stroke and mortality risk.
MUTTON-HF: Can Reclaiming Indigenous Food Systems Reduce Heart Failure Readmissions?
The MUTTON-HF trial evaluates whether culturally and medically tailored meals, incorporating traditional Diné (Navajo) foods, can improve clinical outcomes and quality of life for Indigenous heart failure patients facing nutrition insecurit
High Effectiveness and Rare Safety Risks: Real-World Meta-Analysis Validates RSV Vaccination for Older Adults
A comprehensive meta-analysis of 121.8 million individuals confirms that RSV vaccines are approximately 75% effective against hospitalization and severe disease in older adults, despite low global uptake and a rare risk of Guillain-Barré sy
Cardiovascular Risk Scores Overestimate Mortality in Mexican Adults: The Urgent Need for Population-Specific Recalibration
A prospective study of over 112,000 adults in Mexico City reveals that standard CVD risk scores consistently overestimate 10-year fatal risk. Recalibration of the Globorisk-fatal model significantly improves predictive accuracy, highlightin
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