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ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients
In Medicare beneficiaries, ATTR-CM was diagnosed a median 494 days after heart failure and 840 days after loop diuretic initiation, with delays more common in women and patients with several common comorbidities.

Coronary Stent Trial Site Selection Could Narrow Racial Gaps in Enrollment, but Women Remain Underrepresented
In nine U.S. coronary stent PMA trials, minority participants were markedly underrepresented, while women were modestly underrepresented. Site geography and surrounding county demographics predicted minority enrollment, suggesting targeted

Microplastics in Human Thyroid: A Potential Trigger for Autoimmune Thyroiditis
Microplastics detected in thyroid tissues show higher concentrations in autoimmune thyroiditis patients, suggesting a potential environmental link to thyroid autoimmunity.

Ethnicity, Migration, and Mental Health: Independent Risk Factors Persist in Type 2 Diabetes Disparities
A cohort study reveals persistent ethnic disparities in type 2 diabetes risk, with migration status and mental health conditions as independent contributors, highlighting unmet needs in addressing structural determinants of health inequalit

Intermittent Lifestyle Physical Activity: A Promising Strategy for Type 2 Diabetes Prevention
Brief, intermittent bouts of moderate- to vigorous-intensity physical activity during daily routines may significantly reduce the risk of type 2 diabetes in adults who do not engage in leisure-time exercise.

Global Disparities in Heart Failure: Incidence and Mortality Across Income Levels and Regions
The PURE study reveals significant global disparities in heart failure incidence and mortality, with hypertension as the leading modifiable risk factor, highlighting the need for targeted prevention and treatment strategies.

Geographic Disparities in Opioid Prescribing Patterns for Toothache Pain in the United States
A national study reveals significant state-level and urban-rural variations in opioid prescribing following toothache diagnoses, with 15 states exceeding the national average and rural areas showing slightly lower prescription rates.

Long-term Air Pollution Linked to Adverse Body Composition Changes in Older Adults with Metabolic Syndrome
A study of 1,454 older adults with metabolic syndrome reveals that long-term exposure to air pollutants like black carbon, PM2.5, and NO2 is associated with increased fat mass and decreased lean mass, persisting over three years, particular

Hemorrhage, Hypertensive Disorders, and Infection Are the Leading Underlying Causes of Severe Maternal Morbidity, Study Finds
A new hierarchical algorithm identifies hemorrhage, hypertensive disorders, and infection as the most common underlying conditions for severe maternal morbidity, differing significantly from causes of maternal mortality.

Statistical Inconsistency in ALS Trials: How Analysis Methods Skew Treatment Efficacy
A study reveals significant variability in ALSFRS-R analysis methods across 45 ALS trials, impacting treatment effect estimates and increasing false-positive risks, with implications for clinical decision-making and drug development.

Childhood BMI Trajectories Strongly Predict Adult Metabolic Multimorbidity: A 36-Year Cohort Study Reveals Life-Course Risk Patterns
A 36-year prospective study demonstrates that cumulative BMI burden from childhood to adulthood significantly elevates risks of metabolic multimorbidity, with distinct life-stage patterns and sex-specific vulnerabilities.

Survival of Patients Diagnosed With Cancer During the COVID-19 Pandemic
A cohort study of over 1 million cancer patients revealed significant reductions in 1-year survival rates during 2020-2021 compared to pre-pandemic trends, with an estimated 17,390 excess cancer deaths attributable to pandemic-related care

SAIA-MH Strategy Boosts Mental Health Outcomes in Mozambique: A Breakthrough in Low-Resource Settings
The Systems Analysis and Improvement Approach for Mental Health (SAIA-MH) significantly improved functional outcomes, medication adherence, and appointment attendance in Mozambican outpatient clinics, offering a scalable model for low-resou

Digital Mental Health Interventions Show Promise for Black and Female Health Care Workers
A proactive digital mental health platform improved mental health outcomes for health care workers, with notable benefits for Black and female participants in work productivity and sustained depression reduction.

Produce Prescription for Diabetes Falls Short in Improving Health Outcomes
A randomized trial found that a $80 monthly produce prescription did not significantly improve HbA1c levels or reduce healthcare utilization in diabetic patients at risk of food insecurity.

New Statistical Model Predicts Chronic ITP in Children at Diagnosis
A novel statistical model predicts chronic immune thrombocytopenia (ITP) in children at diagnosis, using age, sex, immunoglobulin levels, and lab values, offering early clinical guidance.

Cartilage Ear Piercings Carry Nearly Double the Complication Risk of Lobule Piercings in a Large Adult Survey
In a large survey of adult ear piercings, auricular cartilage piercings had higher complication and removal rates than lobule piercings, reinforcing the need for careful counseling and informed consent.

Maryland’s Global Budget Revenue Model Was Linked to Better Cancer Surgery Outcomes and Lower Medicare Spending
In a large Medicare study, hospitals under Maryland’s global budget model showed modest but significant improvements in cancer surgery outcomes, driven by fewer complications and shorter stays, with lower inpatient spending.

DASH and Other Healthy Diets Linked to Lower Cognitive Decline Risk in Large U.S. Cohorts
In two large U.S. cohorts, greater adherence to healthy dietary patterns—especially DASH—was associated with less subjective cognitive decline and slightly better objective cognition.

How Matching Algorithms Can Uncover True Patient Counts From Emergency Medical Services Data
A novel matching approach using 911 call time and patient characteristics can effectively identify duplicate EMS responses, enabling more accurate patient-level inferences from response-based datasets with 100% sensitivity and up to 98.6% s
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