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Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement: clot-prevention focused, balanced, and cost-focused. These differences may help personalize postoperative blood thinner choic
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement, highlighting the importance of shared decision-making based on clot risk, bleeding risk, and cost.
Regulatory Framework for Private Equity and Corporatization in Health Care: An ACP Position Paper
ACP warns that private equity in health care can raise costs, weaken clinical autonomy, and affect access and quality, calling for stronger transparency, oversight, and protections for physicians and patients.
Exercise May Be a Disease-Modifying Strategy in Chronic Pancreatitis
A new multimodal study links regular physical activity to lower chronic pancreatitis risk and identifies muscle-derived extracellular vesicles as a plausible mechanism limiting pancreatic inflammation, fibrosis, and ferroptosis.
Genome-First Data Suggest Familial Hypercholesterolemia Is Equally Prevalent Across African and European Ancestry Groups, but Underclassified in African Ancestry Patients
A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassi
Polygenic Scores Often Rival Recurrent CNVs for Psychiatric Risk Stratification, but Both Add Clinical Insight
A large Danish genetic study suggests recurrent CNVs and polygenic scores provide complementary psychiatric risk information, with polygenic scores often identifying more at-risk individuals and potentially modifying CNV-associated risk.
VA Health Professions Trainees Were Disrupted by COVID-19 but Became Meaningful Contributors to Clinical Care, Telehealth, and System Response
A qualitative VA study found that COVID-19 reduced trainee learning opportunities and heightened safety concerns, yet trainees contributed substantially to care delivery, telehealth expansion, patient support, and local pandemic planning.
Medicare Advantage Enforcement Has Been Inconsistent and Financially Modest Despite Expanding Federal Exposure
A 2010-2023 analysis found that CMS enforcement against Medicare Advantage plans was highly variable, usually limited to modest monetary penalties, and more common among lower-rated contracts serving more socially vulnerable beneficiaries.
EBMT Crosses One Million Transplants as Allogeneic HCT and CAR-T Reach New Highs in European Cellular Therapy
The 2024 EBMT activity report marks a major cellular therapy milestone, showing record allogeneic HCT, continued CAR-T expansion, and persistent disparities in donor use, pediatric activity, and country-level access.
Embedding Tobacco Treatment Into Cancer Care Achieved Universal Screening but Exposed Persistent Gaps in Cessation Assistance
A cancer program quality improvement initiative reached a 100% smoking-status ask rate through an electronic hard stop, but assistance for identified smokers remained inconsistent, underscoring the implementation gap between screening and e
Rural-Urban Disparity in Postacute Care and 1-Year Outcomes After Ischemic Stroke
Older stroke patients treated in rural hospitals received less inpatient rehabilitation and more skilled nursing facility care than urban patients, with fewer days at home over 1 year but similar overall mortality.
An Emergency Department Nudge-Based Strategy to Screen and Treat Patients With Alcohol Misuse
A multicomponent emergency department workflow using screening, electronic prompts, and discharge decision support significantly increased naltrexone prescribing for patients with alcohol-related diagnoses.
COPD Cuts Life Expectancy in a Severity-Dependent Manner, With Losses Comparable to or Greater Than Diabetes and Smoking
A large pooled US cohort study found that COPD substantially reduces life expectancy, even among never-smokers, with years of life lost increasing progressively from GOLD stage 1 through stage 4.
Where a Lung Transplant Candidate Is Listed Still Shapes Access to Donor Lungs Under U.S. Continuous Distribution
A national SRTR analysis shows that transplant center geography still strongly influences effective donor access after CAS implementation, and the 2026 proximity-weighted amendment is likely to widen disparities, especially for biologically
Motivational Interviewing and Air Cleaners for Smokers with COPD (MOVE): A Randomized, Double-Blind, Placebo-Controlled Trial
Portable HEPA air cleaners plus motivational interviewing improved symptoms and quality of life in smokers with COPD by reducing indoor particulate matter, though lung function and exacerbations did not significantly change.
French Registry Data Show Marked Declines in Relapse Activity and Faster Diagnosis in AQP4+NMOSD and MOGAD From 2010 to 2024
A nationwide French cohort found earlier diagnosis, falling relapse rates, and major treatment shifts in AQP4+NMOSD and MOGAD, with rituximab linked to lower disability risk in AQP4+NMOSD and overall milder disability trajectories in MOGAD.
Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults
Wearable accelerometer sleep-wake patterns were linked to later dementia risk in two UK cohorts and modestly improved prediction beyond age and standard risk factors.
Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder
A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treat
Do Digital Specialist Consults Really Keep Patients Out of the Hospital?
A new Dutch study suggests e-consults may not dramatically cut hospital referrals overall, but they still offer important benefits when used in the right patients, specialties, and workflows.
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