Section
A Phase III trial of ganaplacide‑lumefantrine (GanLum, KLU156) met its primary non‑inferiority endpoint vs artemether‑lumefantrine, with a PCR‑corrected Day‑29 cure rate of 97.4% (estimand). The drug combines a novel mechanism (ganaplacide)
A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and seve
A prospective Danish cohort found that adults reporting lifetime sexual assault had substantially higher 5‑year incidence of functional somatic disorders—especially multiorgan FSD and chronic widespread pain—after adjustment for psychosocia
In a prospective analysis of 29,105 women from the Nurses’ Health Study II, greater consumption of ultraprocessed foods was associated with a 45% higher odds of early‑onset conventional colorectal adenomas, independent of obesity and
A pooled analysis of three US cohorts shows that maintaining guideline-level activity (~17 MET‑hours/week) consistently over decades is associated with substantial reductions in digestive system cancer incidence and mortality—comparable to
A prespecified pooled analysis of two large randomised pragmatic trials (DANFLU-2 and GALFLU) found high‑dose influenza vaccine reduced hospitalisation for influenza or pneumonia by 8.8% versus standard‑dose in adults ≥65 years, with larger
A nationwide retrospective study from Chile finds that a universal nirsevimab immunisation strategy in 2024 reduced RSV-related lower respiratory tract infection hospitalisations by 76% and ICU admissions by 85%, with an NNT of 35 to preven
A modeling study found that sequential population screening for familial hypercholesterolemia (FH) at ages 10 or 18 is clinically effective but not cost‑effective versus usual care, unless follow-up monitoring and lifestyle interventions fo
The GoFresh randomized trial found that 12 weeks of home‑delivered DASH‑patterned groceries plus dietitian counseling reduced systolic BP by 3.4 mm Hg versus cash stipends and lowered LDL; effects were not sustained three months after the i
A phase 1 trial of the rVSV‑vectored Lassa vaccine demonstrated dose-dependent transient reactogenicity, no vaccine‑related serious adverse events or hearing loss, and robust, durable humoral and cellular responses across doses and lineages
A concise synthesis of a 2025 multistakeholder Lancet workshop consensus on population and clinical strategies to prevent, detect, and manage alcohol‑associated liver disease.
A global systematic review (110 cohorts, 50 countries) found substantial attrition across the hepatitis B care cascade: low rates of treatment eligibility assessment and antiviral initiation in primary/community models, poor retention parti
In a prospective Beijing cohort (BLINDSCE), each additional hour of daily sedentary time was associated with a 1.18-point lower baseline intrinsic capacity and a 0.48-point greater decline over 1 year, suggesting sedentary behavior is a mod
An evidence-based synthesis of the 2025 Taipei Global Consensus II: 28 statements guiding H. pylori screening, eradication, surveillance and stewardship to reduce gastric cancer at individual and population levels.
A landmark study challenges the metabolic benefits of time-restricted eating, revealing its effects primarily stem from calorie reduction rather than meal timing, while highlighting its influence on the biological clock.
A concise, clinician- and public-facing synthesis of the JAMA Summit consensus outlining a 2040 vision and five near-term actions to substantially reduce firearm harms.
A multifaceted national preterm birth prevention programme in Australia was associated with a modest national decrease in late preterm births and, after a hospital collaborative, a substantial reduction in early‑term births in participating
A pragmatic stepped‑wedge trial of the CRADLE device and training in Sierra Leone increased vital‑sign measurement and accuracy but did not lower a composite of eclampsia, emergency hysterectomy, maternal death, or stillbirth; systemic barr
An expert Delphi consensus from ISTAART lays out core data, methods and research priorities to harmonize sleep and circadian studies in aging and Alzheimer’s disease.
Systematic review and meta-analysis of 22 studies finds player contact and non-contact mechanisms dominate; ankle (25.8%) and knee (15.5%) injuries account for 41% of injuries. Females have higher rates of knee, concussion, and ball-contact
