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A large-scale UK Biobank study demonstrates that combining NMR metabolomics, polygenic risk scores, and clinical biomarkers with SCORE2 significantly enhances cardiovascular risk prediction, potentially doubling the number of prevented even
A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events
A large-scale cohort study demonstrates that delaying statin therapy following the incidental discovery of high LDL-C during routine health screenings leads to a progressively higher risk of myocardial infarction, emphasizing the critical i
Emerging evidence confirms that air pollution, particularly PM2.5 and NO2, is directly associated with Alzheimer’s neuropathology, structural brain changes, and cognitive decline. New research highlights that these effects are partially med
This review analyzes the long-term effectiveness of RSV vaccination among US Veterans, revealing significant protection against severe outcomes that wanes over two seasons, particularly in immunocompromised populations.
This review analyzes the significant shift in type 2 diabetes prescribing patterns following California’s 2022 Medi-Cal expansion, highlighting how policy-driven access to SGLT-2 inhibitors and GLP-1 receptor agonists narrowed health
A large, rigorous study found that sertraline, an antidepressant, does not significantly lower the risk of repeated violent crimes among impulsive offenders.
Electronic behavioral nudges significantly improve influenza vaccination rates among patients with chronic and cardiovascular diseases, offering scalable public health strategies.
A prospective study of 1071 couples identifies that plasma trace metal concentrations in both partners significantly influence IVF success, with elements like iron and molybdenum showing benefits while silver and thallium pose risks to embr
A large-scale longitudinal study reveals that ICU survivors aged 60–79 face significantly higher 5-year excess mortality and functional decline compared to the general population, whereas outcomes for nonagenarians converge with their peers
A large-scale study of over 700,000 young adults reveals a concerning decline in lipid follow-up and statin initiation between 2008 and 2018, highlighting a critical care gap in preventing premature cardiovascular disease during a key windo
A Norwegian population-based study of 492 women aged 18-22 reveals significant inter-individual variability in ovarian volume, antral follicle count, and AMH levels, providing a critical baseline for understanding reproductive health before
The FLUNITY-HD pooled analysis of over 466,000 older adults demonstrates that high-dose inactivated influenza vaccine (HD-IIV) significantly reduces hospitalizations for influenza, pneumonia, and cardiovascular causes, including a 21.3% red
A global Heart Rhythm Society survey reveals that 41% of EP professionals suffer from orthopedic injuries and 50% of women face pregnancy complications, highlighting the urgent need for systemic improvements in laboratory ergonomics and rad
This study identifies key modifiable surgical and hospital-level factors—including surgical approach and antibiotic adherence—that contribute to the disproportionately higher rate of postoperative complications experienced by Black patients
An mHealth text messaging intervention significantly improves smoking cessation rates and reduces mortality among TB patients compared to usual care, supporting its implementation in TB programs.
The U.S. Senate’s unanimous passage of the FDA Modernization Act 3.0 marks a definitive shift in drug regulation, formally replacing ‘animal’ mandates with ‘nonclinical’ methodologies like organ-on-a-chip and A
A comprehensive population study of 450,453 deaths identifies specific occupations, including fishing, mining, and funeral services, with disproportionately high cancer mortality, suggesting a complex interplay of workplace exposures and st
From 2010 to 2019, NCD mortality declined in 80% of countries worldwide, driven primarily by reductions in circulatory diseases, with notable regional and cause-specific heterogeneity and slower progress than the previous decade.
A 4-year randomized controlled trial found that computer-generated feedback letters failed to reduce alcohol consumption in the general population. Unexpectedly, the control group showed greater reduction at 48 months, suggesting that curre
