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A comprehensive 2025 systematic review informing the Canadian Task Force finds cytology remains effective into the 60s, HPV-based strategies detect more precursors but increase colposcopy and false positives, and self-sampling improves upta
A novel live attenuated oral vaccine, CVD 1902, shows 73% efficacy against Salmonella Paratyphi A infection in a controlled human challenge model, offering promising protection with a favorable safety profile.
A nested observational study within the E-MOTIVE trial revealed that adopting a lower blood loss threshold combined with clinical signs leads to earlier diagnosis of postpartum haemorrhage, facilitating prompt interventions and reducing adv
RSV vaccines demonstrate substantial effectiveness and acceptable safety profiles in adults aged ≥60, with diminished effectiveness in immunocompromised subgroups and a low, statistically significant increased risk of Guillain-Barré syndrom
A systematic review supports the continued safety and effectiveness of Covid-19, RSV, and influenza vaccines for the upcoming 2025-2026 season, highlighting detailed vaccine efficacy, safety profiles, and recommendations for at-risk populat
This study evaluates whether initiating ADHD stimulant prescriptions via telehealth affects later risks of stimulant or other substance use disorders, finding no SUD risk increase but a potential rise in stimulant use disorder risk.
This national study reveals significant ethnoracial disparities in schizophrenia spectrum disorders prevalence linked to neighborhood social vulnerability, highlighting structural racism’s role in mental health inequities among non-Hi
This longitudinal study reveals distinct trajectories of depressive symptoms among Chinese adolescents, highlighting key sociodemographic and behavioral predictors that can inform early intervention strategies.
A comprehensive Singaporean cohort study reveals increased odds of cardiovascular complications during the first 30 days post-acute dengue infection, especially in older adults, emphasizing the need for targeted cardiac monitoring.
A 14-year population-based cohort study in the Netherlands found that higher Dutch OBCT index scores—reflecting obesogenic environmental characteristics—are associated with a modest but significant increase in cardiovascular disease inciden
State-level repeal of nonmedical vaccine exemptions significantly improves kindergarten vaccination rates across multiple vaccines, with minimal increase in medical exemptions, highlighting its role in sustaining herd immunity amid growing
New evidence from the UK Biobank reveals that clinical obesity, defined by obesity-related dysfunctions, significantly elevates all-cause mortality risk. Early detection and intervention are key to reducing mortality associated with both pr
Over 21 years, intensive lifestyle changes and metformin significantly reduced type 2 diabetes incidence in at-risk adults, with variable effects based on individual baseline risk factors, highlighting opportunities for precision prevention
A novel pediatric-specific atlas of US acute care regions was developed using Medicaid data, revealing distinct patterns in emergency and referral care and providing a foundation for targeted pediatric healthcare planning and quality improv
Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for i
Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.
A secondary analysis of a cluster-randomized trial found that portable HEPA purifiers modestly reduced viral diversity but did not significantly lower high respiratory viral exposure in elementary school classrooms, suggesting multi-faceted
This study nested within the E-MOTIVE trial reveals that using a lower blood loss threshold combined with clinical signs leads to earlier postpartum haemorrhage diagnosis and intervention, potentially reducing adverse outcomes in diverse Af
This study evaluates targeted indoor residual spraying’s effectiveness against Aedes-borne diseases and highlights its limitations despite entomologic success.
This study reveals that both low and high ambient temperatures significantly increase mortality risk among Swedish heart failure patients, highlighting the need for climate adaptation strategies in high-latitude regions.
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