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Brand-Specific Influenza Vaccine Effectiveness in Nordic Older Adults: Insights from the 2024-2025 Season Registry-Based Target Trial Emulation
This comprehensive review synthesizes recent evidence on brand-specific influenza vaccine effectiveness (VE) among adults aged ≥65 in Denmark, Finland, and Sweden during the 2024-2025 season, underscoring heterogeneous VE profiles and the c
Peer Self-harm Predicts a Small Increase in Adolescent Risk with a Peak at Age 16: Findings from a Nationwide Finnish Cohort
A Finnish registry cohort (n=913,149) found that exposure to same-grade schoolmates’ self-harm modestly increased later self-harm risk (HR 1.05), with the largest effect around age 16 (HR ~1.45), suggesting time-limited social transmission
Wildfire Smoke During Pregnancy Linked to Higher Preterm Birth Risk in the US West: ECHO Cohort Analysis Shows Intensity, Duration, and Timing Matter
A nationwide ECHO analysis found wildfire-specific PM2.5 exposure was associated with increased odds of preterm birth in the US West, with stronger effects for higher concentration, longer smoke waves, and mid-to-late pregnancy exposures.
IDSA 2025 Update: Stronger Flu and RSV Vaccine Recommendations for Immunocompromised People — What Clinicians Need to Know
The Infectious Diseases Society of America now recommends annual high-dose or adjuvanted influenza vaccine and a single RSV dose for most immunocompromised persons; timing around immunosuppression and household immunization are emphasized.
Urban Greenness Associated with Fewer Mental-Health Hospital Admissions — But Effects Vary Across Countries
A multinational time-series analysis of 11.4 million admissions found that higher neighbourhood greenness (NDVI) was linked to lower hospital admissions for mental disorders overall, with heterogeneity across countries and disorder types an
Unequal and Multisystem Mortality Risks After Tropical Cyclones: Renal, Injury, Infectious and Chronic Disease Burdens Across Nine Countries
A multinational time-series study across nine countries found increased short-term mortality after tropical cyclones for multiple causes — highest for renal disease and injuries — with larger effects in deprived and cyclone-naïve communitie
Pfizer’s Modified mRNA Quadrivalent Influenza Vaccine Demonstrates 34.5% Relative Efficacy vs Licensed Inactivated Vaccine in Phase 3 Trial
A phase 3 trial of Pfizer’s quadrivalent modified mRNA influenza vaccine (n≈18,476) showed 34.5% relative efficacy vs a licensed inactivated vaccine for laboratory-confirmed influenza (A strains) with higher reactogenicity but low rates of
Temporary Inpatient Hemodialysis Access for Uninsured Patients Is Associated with Shorter Hospital Stays in a County Safety-Net System
A Los Angeles County quality-improvement study found that regulatory approval allowing an inpatient hemodialysis unit to provide transitional outpatient dialysis to uninsured patients initiating hemodialysis was associated with a substantia
Weight Trajectories Among Youths Following Residential Relocation
This study explores how changes in residential environments affect childhood BMI, focusing on air pollution, built environment, and socioeconomic factors across cohorts in the Netherlands, Sweden, and Czech Republic.
Preoperative CT Was Missing in 15% of Balloon Sinus Dilations — Medicare Claims Reveal a Clinically Significant Practice Gap
A Medicare claims study of 19,692 balloon sinus dilations found 15% lacked a CT within one year; 31.8% of otolaryngologists were outliers, with a small group accounting for most missed imaging, highlighting gaps in adherence to preoperative
Most Host Countries Don’t Get Timely Access to Medicines They Help Test: An Analysis of FDA-Supported Trials (2015–2018)
A cross-sectional analysis (FDA approvals 2015–2018) found that most countries hosting pivotal trials lack timely market authorization for tested medicines, especially lower- and middle-income countries—raising ethical, regulatory, and poli
Short Program, Long Gains: A 24‑Week Multicomponent Frailty Intervention Extended Disability‑Free Survival and Delivered Net Health-System Savings Over 66 Months
A 24‑week, community-based multicomponent frailty intervention in rural Korea was associated with 6.5 additional months free from death or long‑term care eligibility and ~$7,700 per-person NHIS savings over 66 months, suggesting durable cli
Boosting Mammogram Screening Rates: What Really Works for Overdue Women?
A Singapore trial shows simple mailed reminders effectively increase overdue mammogram screenings; additional incentives or digital interventions offer no significant benefit.
Reduced Arsenic in Drinking Water Tied to Large Drops in Cancer and Cardiovascular Mortality
A prospective cohort in Bangladesh found that declines in urinary arsenic were associated with substantially lower chronic-disease mortality—including cancer and cardiovascular deaths—supporting public-health efforts to reduce arsenic expos
The Power of Persistence: How Consistent Moderate Exercise Significantly Lowers Digestive Cancer Risk
A Harvard study following 230,000 people over 32 years shows that regular, moderate exercise sustained over time is more effective at preventing digestive system cancers than sporadic high-intensity workouts.
A Novel H3N2 Variant on the Rise: What Clinicians and Public Health Systems Need to Know for 2025–26
Emerging H3N2 subclade K has driven increased influenza activity abroad and may seed the 2025–26 northern hemisphere season. Surveillance gaps complicate risk assessment; vaccination and early antiviral use remain central clinical strategie
Bird Flu Returns: Understanding the Risks and Staying Safe
An adult male in Washington has tested positive for avian flu, marking a resurgence after 9 months. This article explores the scientific evidence, recent outbreaks, and practical advice to prevent infection.
Stopping Smoking Is Associated With Better Recovery From Other Substance Use Disorders: Longitudinal Evidence From a US National Cohort
A longitudinal, nationally representative cohort study found that within-person transition from current to former cigarette smoking was associated with a 30–43% higher odds of sustained recovery from other substance use disorders, supportin
Unlocking Longevity: The Science of Sleep and Its Vital Role in Health
Quality sleep, balancing deep NREM and REM phases, is crucial for immunity, brain function, and disease prevention, highlighting sleep’s key role in longevity and overall health.
GanLum (KLU156): A New Class of Antimalarial Showing 97.4% PCR‑Corrected Cure in Phase III
A Phase III trial of ganaplacide‑lumefantrine (GanLum, KLU156) met its primary non‑inferiority endpoint vs artemether‑lumefantrine, with a PCR‑corrected Day‑29 cure rate of 97.4% (estimand). The drug combines a novel mechanism (ganaplacide)
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