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Distinct and Shared Risk Profiles for Suicide Attempt Versus Suicide: Insights from Danish Registers and Genomic Data
A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and seve
Sexual Assault and the Long Shadow of the Body: Higher 5‑Year Risk of Functional Somatic Disorders and Chronic Widespread Pain
A prospective Danish cohort found that adults reporting lifetime sexual assault had substantially higher 5‑year incidence of functional somatic disorders—especially multiorgan FSD and chronic widespread pain—after adjustment for psychosocia
Higher Ultraprocessed Food Intake Linked to Increased Risk of Early‑Onset Colorectal Adenomas in Women
In a prospective analysis of 29,105 women from the Nurses’ Health Study II, greater consumption of ultraprocessed foods was associated with a 45% higher odds of early‑onset conventional colorectal adenomas, independent of obesity and other
Consistency Over Excess: Long-term Adherence to Physical Activity Guidelines Reduces Digestive System Cancer Risk
A pooled analysis of three US cohorts shows that maintaining guideline-level activity (~17 MET‑hours/week) consistently over decades is associated with substantial reductions in digestive system cancer incidence and mortality—comparable to
High‑Dose Influenza Vaccine Reduces Hospitalisations in Older Adults
A prespecified pooled analysis of two large randomised pragmatic trials (DANFLU-2 and GALFLU) found high‑dose influenza vaccine reduced hospitalisation for influenza or pneumonia by 8.8% versus standard‑dose in adults ≥65 years, with larger
Nirsevimab in Chile’s First National RSV Campaign: 76% Reduction in RSV Hospitalisations and 85% Fewer ICU Admissions in Infants
A nationwide retrospective study from Chile finds that a universal nirsevimab immunisation strategy in 2024 reduced RSV-related lower respiratory tract infection hospitalisations by 76% and ICU admissions by 85%, with an NNT of 35 to preven
Screening Children and Young Adults for Familial Hypercholesterolemia: Clinically Helpful but Not Cost‑Effective
A modeling study found that sequential population screening for familial hypercholesterolemia (FH) at ages 10 or 18 is clinically effective but not cost‑effective versus usual care, unless follow-up monitoring and lifestyle interventions fo
Home‑Delivered DASH Groceries Lower Blood Pressure and LDL in Black Urban Residents — but Benefits Fade After Support Ends
The GoFresh randomized trial found that 12 weeks of home‑delivered DASH‑patterned groceries plus dietitian counseling reduced systolic BP by 3.4 mm Hg versus cash stipends and lowered LDL; effects were not sustained three months after the i
rVSVΔG‑LASV‑GPC Lassa Vaccine Shows Broad Immunogenicity and Acceptable Safety in Phase 1 Trial
A phase 1 trial of the rVSV‑vectored Lassa vaccine demonstrated dose-dependent transient reactogenicity, no vaccine‑related serious adverse events or hearing loss, and robust, durable humoral and cellular responses across doses and lineages
Cutting the Curve: Consensus Strategies to Reduce Alcohol‑Associated Liver Disease in the Population
A concise synthesis of a 2025 multistakeholder Lancet workshop consensus on population and clinical strategies to prevent, detect, and manage alcohol‑associated liver disease.
Where Are People with Chronic Hepatitis B Lost? Global review shows major gaps after diagnosis — especially outside specialist care
A global systematic review (110 cohorts, 50 countries) found substantial attrition across the hepatitis B care cascade: low rates of treatment eligibility assessment and antiviral initiation in primary/community models, poor retention parti
Each Hour Sitting Counts: Sedentary Time Linked to Lower Intrinsic Capacity and Faster Decline in Older Adults
In a prospective Beijing cohort (BLINDSCE), each additional hour of daily sedentary time was associated with a 1.18-point lower baseline intrinsic capacity and a 0.48-point greater decline over 1 year, suggesting sedentary behavior is a mod
Taipei Global Consensus II (2025): A Practical Guide to Helicobacter pylori Screening and Eradication for Gastric Cancer Prevention
An evidence-based synthesis of the 2025 Taipei Global Consensus II: 28 statements guiding H. pylori screening, eradication, surveillance and stewardship to reduce gastric cancer at individual and population levels.
Time-Restricted Eating: Separating Facts from Fad in Metabolic Health
A landmark study challenges the metabolic benefits of time-restricted eating, revealing its effects primarily stem from calorie reduction rather than meal timing, while highlighting its influence on the biological clock.
Toward a Safer 2040: Key Actions from the JAMA Summit on Reducing Firearm Violence and Harms
A concise, clinician- and public-facing synthesis of the JAMA Summit consensus outlining a 2040 vision and five near-term actions to substantially reduce firearm harms.
Nationwide Prevention Programme in Australia Associated with Lower Preterm and Early‑Term Singleton Births: National and Hospital‑Level Results
A multifaceted national preterm birth prevention programme in Australia was associated with a modest national decrease in late preterm births and, after a hospital collaborative, a substantial reduction in early‑term births in participating
National Scale-up of the CRADLE Vital Signs Alert in Sierra Leone Improved Detection but Did Not Reduce Maternal or Perinatal Adverse Outcomes
A pragmatic stepped‑wedge trial of the CRADLE device and training in Sierra Leone increased vital‑sign measurement and accuracy but did not lower a composite of eclampsia, emergency hysterectomy, maternal death, or stillbirth; systemic barr
New International Research Recommendations on Sleep and Circadian Measures in Aging and Alzheimer’s Disease
An expert Delphi consensus from ISTAART lays out core data, methods and research priorities to harmonize sleep and circadian studies in aging and Alzheimer’s disease.
Ankle and Knee Dominance, Female Vulnerability, and Game-Time Risk: Contemporary Injury Incidence in Basketball Players
Systematic review and meta-analysis of 22 studies finds player contact and non-contact mechanisms dominate; ankle (25.8%) and knee (15.5%) injuries account for 41% of injuries. Females have higher rates of knee, concussion, and ball-contact
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