Psychiatry
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Association Between Delivery Mode and Postpartum Psychiatric Conditions
A large U.S. cohort study found higher rates of postpartum psychiatric conditions after planned or unplanned cesarean delivery, but not after successful operative vaginal delivery, highlighting the need for closer postpartum mental health f
Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial
In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antip
Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder
A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treat
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial
Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.
Implementation of a Hospital-Based Screening and Treatment Program for Unhealthy Alcohol Use
A hospital-based screening and treatment program for unhealthy alcohol use was feasible in a diverse safety-net population and was linked to short-term reductions in alcohol risk scores, especially among patients who received follow-up and
Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia
A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im
Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial
A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi
Initiation of Medications for Alcohol Use Disorder Among Hospitalized Veterans : A Retrospective Cohort Study
VHA study reveals only 30% of veterans hospitalized for AUD receive evidence-based medications during or shortly after hospitalization, with significant variation across hospitals and demographic factors influencing prescription rates.
A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial
In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.
Intersection of Intimate Partner Violence and Substance Use Disorders in the Veteran Population: Screening Gaps, Risk Profiles, and Lethality
This review synthesizes evidence on the high prevalence and severity of intimate partner violence (IPV) among veterans with substance use disorders, highlighting gender-specific lethality risks and the critical need for integrated screening
Semaglutide Reduced Effort Discounting and Improved Motivation Signals in Major Depressive Disorder
In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dy
SAIA-MH Strategy Boosts Mental Health Outcomes in Mozambique: A Breakthrough in Low-Resource Settings
The Systems Analysis and Improvement Approach for Mental Health (SAIA-MH) significantly improved functional outcomes, medication adherence, and appointment attendance in Mozambican outpatient clinics, offering a scalable model for low-resou
Digital Mental Health Interventions Show Promise for Black and Female Health Care Workers
A proactive digital mental health platform improved mental health outcomes for health care workers, with notable benefits for Black and female participants in work productivity and sustained depression reduction.
Semaglutide Shows Promise in Reducing Mental Illness Worsening in Patients with Depression and Anxiety, Swedish Study Finds
A landmark Swedish cohort study of 95,490 patients reveals that semaglutide is associated with a 42% lower risk of worsening mental illness in people with depression and anxiety, while other GLP-1 receptor agonists show varied effects. The
Machine Learning Falls Short in Personalizing School-Based Mindfulness for Adolescent Depression Prevention: MYRIAD Trial Insights
Secondary analysis of the MYRIAD trial reveals that while machine learning models can identify adolescents who may benefit from school-based mindfulness training, the clinical relevance of such predictions remains minimal. Both causal fores
Past-Year Emergency Department Utilization Patterns Among Suicide Decedents: Characterizing At-Risk Patient Populations
This study analyzes emergency department visit patterns among suicide decedents, identifying frequent users and a critical 30-day window for intervention after discharge.
Untreated Maternal Depression Linked to Increased Outpatient Opioid Use Following Cesarean Delivery
A large multicenter study finds that while maternal depression does not affect inpatient opioid use after cesarean delivery, untreated depression significantly increases outpatient opioid consumption and perceived pain interference during t
The Human Cost of Respiratory Care: Why Multidisciplinary Teams Cannot Shield Physicians from Burnout
A comprehensive study of 569 cystic fibrosis professionals identifies physicians as the group most vulnerable to burnout, emotional exhaustion, and depersonalization. The research highlights administrative burden as a primary driver and cal
Psychological Burden in Thyroid Cancer Survivorship: Real-World Evidence on Antidepressant Prescription Patterns
A large-scale Korean cohort study reveals thyroid cancer survivors face a significantly higher risk of depression in the first five years post-diagnosis, independent of treatment modality or hormone dosage.
Analyzing Emergency Department Utilization Patterns Among Suicide Decedents: Characterizing At-Risk Patient Populations
This study examines the timing and frequency of emergency department visits among individuals who died by suicide. Research identifies frequent ED use as a high-risk indicator and suggests that the 30-day window following an emergency visit
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