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This study reveals region- and size-specific dendritic spine deficits in cortical layer 3 neurons of schizophrenia patients, highlighting differential synaptic disruptions across visual and prefrontal cortical areas underpinning cognitive d
Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.
The PAX-BD trial assessed pramipexole addition to mood stabilisers in treatment-resistant bipolar depression, revealing some mood and psychosocial benefits but no significant primary outcome improvement, highlighting the need for further re
The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant
This article explores the link between prenatal and early postnatal lead exposure and adult anxiety and depression, emphasizing critical exposure windows and long-term mental health implications.
This study applies machine learning and explainable AI to identify factors associated with chronic pain, psychological distress, and their co-occurrence in Norwegian young adults, highlighting the importance of integrated approaches for ear
This review synthesizes evidence linking long-term air pollution and road traffic noise exposure with antidepressant medication dispensing, highlighting sex-specific associations and implications for mental health prevention strategies.
This prospective study reveals that prolonged exposure to fine particulate matter (PM2.5) significantly elevates risks of depression and anxiety, disproportionately affecting Black populations due to systemic inequities. Findings call for t
This study reveals that long-term treatment with lithium or valproate significantly lowers suicide risks in bipolar disorder patients. Combining atypical antipsychotics with these mood stabilizers further reduces suicide incidence, offering
A comprehensive 50-state survey reveals widespread conspiratorial thinking among American adults linked to demographic factors and COVID-19 vaccine hesitancy, with implications for public health strategies.
The HISTORI trial demonstrates that semaglutide significantly improves glycemic control, reduces weight, and enhances physical quality of life in schizophrenia patients treated with second-generation antipsychotics, without worsening psychi
Azetukalner, a KV7 potassium channel opener, demonstrated clinically meaningful antidepressant effects and significant improvement in anhedonia in adults with major depressive disorder in a 6-week randomized trial, supporting further develo
A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.
Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.
A comprehensive study spanning 47 countries reveals changing suicide mortality rates among adults aged 65+, highlighting method-specific risks and projecting future trends amid global population ageing.
A cluster randomised controlled trial demonstrates that the Conversations about Suicide course delivered in Australian Men’s Sheds significantly improves recommended suicide prevention actions among older men, with sustained effects a
This study highlights how poor mental well-being during adolescence predicts increased risks of mental illness, risky behaviors, and mortality in young adulthood, emphasizing the urgency for early identification and intervention.
This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.
This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.
A nationwide study in Spain from 2018 to 2023 reveals increasing rates of non-lethal intentional self-harm and suicide, particularly among young women, underscoring the need for targeted mental health interventions.
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