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A meta-analysis found a population-level association between increased per capita alcohol consumption and higher suicide mortality, without sex differences, suggesting alcohol reduction as a vital component in suicide prevention.
A retrospective study identifies critical gaps in screening and treatment of perinatal anxiety and depression, revealing prevalence rates, symptom trajectories, and the impact of mental health services in 3051 women.
A phase 2 trial in adults with major depressive disorder demonstrated that ammoxetine at 40 mg/d and 60 mg/d significantly improved depressive symptoms compared to placebo and was generally well tolerated, offering a novel treatment option
This article critically reviews measurement properties of the PHQ-15 and SSS-8, two key instruments assessing somatic symptom burden, highlighting reliability, validity, and clinical applicability based on meta-analyzed evidence from over 3
This review synthesizes evidence on bilateral continuous theta burst stimulation (cTBS) of the temporo-parietal cortex for persistent auditory verbal hallucinations (AVH) in schizophrenia, focusing on a landmark German phase 3 trial demonst
This study evaluated the antidepressant effects of a Lactobacillus probiotic in overweight depressed patients with systemic low-grade inflammation, revealing no overall benefit but highlighting fecal formic acid as a potential biomarker for
A 3-month RCT demonstrates that multi-species probiotic supplementation improves vagal nerve function, gut microbiome composition, and sleep quality in patients with major depression, suggesting novel gut-brain axis interventions.
The AID-ME trial demonstrates that an AI-powered clinical decision support system significantly improves remission rates and accelerates symptom improvement in moderate to severe major depressive disorder.
A randomized clinical trial in Pakistan demonstrates that measurement-based care accelerates antidepressant treatment response and remission in major depressive disorder compared to standard care, underscoring its potential in low-resource
A randomized clinical trial demonstrates that personalized high-definition transcranial direct current stimulation (HD-tDCS) significantly improves mood in patients with moderate to severe depression, showing faster and comparable effect si
The Smart-T smartphone intervention significantly improves 7-day smoking abstinence at 26 weeks in low-income adults, outperforming the standard QuitGuide app when combined with nicotine replacement therapy.
A randomized trial demonstrates that graphic health warnings on little cigars and cigarillos significantly increase quitting intentions and related behaviors compared to FDA text-only warnings or no warnings, highlighting the need for enhan
A secondary analysis of four randomized trials reveals that additional behavioral therapy does not significantly improve opioid abstinence, retention, or functional outcomes when added to buprenorphine and medical management in opioid use d
This cluster-randomized trial evaluated an automated tobacco cessation intervention for parents in pediatric primary care, finding no significant increase in 1-year quit rates but notable improvements in treatment engagement and smoking red
A phase 4 randomized trial demonstrates that esketamine nasal spray monotherapy significantly reduces depressive symptoms in adults with treatment-resistant depression, offering a promising alternative to oral antidepressants.
A 4-week randomized trial shows that low-dose cannabidiol (CBD) may cause transient liver enzyme elevations in healthy adults, emphasizing the need for vigilance and further safety assessment of consumer CBD products.
A cluster randomized trial demonstrates that an electronic health record–integrated clinical decision support system increases naloxone prescriptions and opioid use disorder treatments in primary care but does not change diagnosis rates or
A pilot study demonstrates that a self-guided digital psychological intervention significantly reduces psychological distress and improves quality of life in patients with inflammatory rheumatic diseases, offering a scalable mental health s
A pilot randomized clinical trial demonstrates that a self-guided digital psychological intervention effectively reduces psychological distress and improves quality of life among patients with inflammatory rheumatic diseases.
A prospective UK Biobank study reveals that diets with higher pro-inflammatory potential, as measured by the Dietary Inflammatory Index, are significantly associated with increased risk of depressive and anxiety symptoms and disorders over
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