Pediatrics
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346 articles · 20 / page
Delays in Pediatric Cannabis Toxicology Testing Lead to Increased Neuroimaging in Emergency Departments
Delayed cannabis test results in children under 6 with poisoning symptoms prolong ED visits and influence neuroimaging use. Faster toxicology screening could optimize care and reduce unnecessary scans.
FDA Approves Golimumab (Simponi) for Pediatric Ulcerative Colitis: A New Therapeutic Option
The FDA has approved golimumab (Simponi) for treating moderately to severely active ulcerative colitis in children weighing at least 15 kg, based on the PURSUIT 2 phase 3 study demonstrating significant clinical remission and safety.
Trends in Body Composition and Cardiometabolic Risk Factors in Spanish Children Over Three Decades
This article reviews a 30-year study from Spain analyzing body composition and cardiometabolic risk factors in children aged 8-11, showing obesity plateauing, lipid improvements, blood pressure reductions, but rising insulin levels from 199
Evaluating the Incremental Benefit of Two Versus One Dose of Influenza Vaccine in Influenza-Naive Children Under Nine: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis assess the additional protection from a second dose of influenza vaccine in vaccine-naive children under nine years old, highlighting significant benefits particularly for those under three years.
Revisiting Rehydration Strategies in Severe Acute Malnutrition with Gastroenteritis: Intravenous Versus Oral Approaches
A recent trial assessing intravenous versus oral rehydration in children with severe acute malnutrition and gastroenteritis found no mortality difference at 96 hours, challenging fears of fluid overload and supporting cautious consideration
Memantine Shows Promise for Improving Social Impairment in Youths with Autism Spectrum Disorder
A 12-week randomized clinical trial demonstrates memantine’s efficacy and safety in improving social impairments in youths with ASD, with elevated pgACC glutamate levels serving as a predictive biomarker for treatment response.
Long-Term Educational Trajectories After Preterm Birth: Unraveling the Roles of Biological and Sociodemographic Factors
This study reveals that although individuals born preterm face higher risks of lower educational attainment, sociodemographic factors have a greater impact on long-term educational outcomes than prematurity itself.
Decoding Nonverbal Learning Disability in Children: Distinct Profiles and Their Clinical Implications
A cross-sectional study identifies four distinct profiles of nonverbal learning disability (NVLD) in children, revealing significant heterogeneity in visual-spatial deficits, academic skills, and psychiatric diagnoses, highlighting implicat
Unraveling ADHD: Gut Microbial Signatures and the Role of SCFA Deficiency in Symptom Pathogenesis
Recent research reveals distinct gut microbial and metabolic profiles linked to ADHD symptoms, highlighting short-chain fatty acid deficiency as a key mechanism driving hyperactivity and inattention.
Restoring Cognitive Function After Adolescent Alcohol Exposure: The Promise of Synbiotic Therapy Targeting the Microbiota-Gut-Brain Axis
A synbiotic intervention reverses alcohol-induced cognitive deficits in adolescent mice by modulating gut microbiota and brain metabolism, suggesting potential therapeutic avenues for alcohol-related neurobehavioral impairments.
In-Home Firearm Homicides Among Children and Adolescents: Understanding a Hidden Crisis
Nearly one-quarter of firearm-related homicides of US children and adolescents occur at home, particularly affecting younger children, with domestic violence and child abuse as major factors.
Understanding RSV: Why Immunization Is a Game-Changer for Infants and Vulnerable Adults
Respiratory Syncytial Virus (RSV) poses serious risks to infants and older adults. Since 2023, RSV immunizations have drastically reduced hospitalizations and deaths. This article explains RSV, symptoms, immunization options, and prevention
Clinical Long-Read Sequencing: A Game-Changer in Pediatric Genetic Disease Diagnosis
Clinical long-read sequencing (LRS) demonstrates superior diagnostic yield and shorter turnaround times compared to standard genetic testing in pediatric genetic diseases, consolidating multiple tests into one comprehensive assay and identi
Antenatal Betamethasone Reduces Respiratory Morbidity in Late Preterm Twins: Landmark Randomized Trial
This multicenter randomized trial demonstrates that antenatal betamethasone significantly lowers severe respiratory morbidity in late preterm twin neonates, offering evidence-based guidance for managing twin pregnancies at imminent preterm
Progression of Transdiagnostic Clinical Stages From Childhood to Young Adulthood: Evidence and Implications
This review synthesizes cohort and longitudinal studies supporting the progression of transdiagnostic mental health stages from familial risk in childhood through early symptoms in adolescence to clinically significant disorders in young ad
Navigating Childhood Insurance in the US: Insights into Medicaid, CHIP, and Uninsurance Dynamics
A simulation study reveals that 75% of US children experience publicly subsidized insurance or uninsurance periods by age 18, highlighting the impact of state Medicaid policies on pediatric coverage gaps.
Understanding Patient Acceptance of Complement Inhibitor Therapy in Geographic Atrophy
A UK study reveals most patients with geographic atrophy are open to intravitreal complement inhibitor injections if these treatments offer vision improvement, highlighting the vital role of functional benefits in therapy acceptance.
Atropine vs Cyclopentolate: Optimizing Premyopia Diagnosis in Preschool Children
This study compares atropine and cyclopentolate for cycloplegia in preschoolers, finding atropine leads to less myopic refraction and may reduce premyopia overestimation. It highlights implications for precise refractive diagnosis in young
Clesrovimab: A Promising Monoclonal Antibody for Preventing RSV in Healthy Infants
A single dose of clesrovimab significantly reduces respiratory syncytial virus (RSV) infections and hospitalizations in healthy infants during their first RSV season, with a safety profile comparable to placebo.
Evaluating Radiation Risks from Medical Imaging in Pediatrics: Implications for Hematologic Cancer
A large cohort study links radiation exposure from pediatric medical imaging to a modest but significant increase in hematologic cancer risk, underlining the need for judicious imaging use in children and adolescents.
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