Pediatrics
Latest news
346 articles · 20 / page
Outpatient Versus Inpatient Care for Young Infants with Single Low-Risk PSBI Signs: Insights from a Multicentre Trial in Sub-Saharan Africa and South Asia
A randomized trial found outpatient treatment of young infants with a single low-mortality-risk sign of possible serious bacterial infection is non-inferior to inpatient care, with lower mortality rates and comparable safety.
Optimizing Antibiotic Duration in Young Infants with Possible Serious Bacterial Infection: A Landmark Multicountry RCT
This multicountry trial demonstrates that early switch from injectable to oral antibiotics with early discharge in young infants with moderate-risk serious bacterial infections is safe and effective, with potential to optimize healthcare re
Evaluating Fentanyl Use in Pediatric Ileocolic Intussusception Reduction: Implications for Pain Management and Success Rates
A large multicenter study finds no association between fentanyl administration and failed reduction of pediatric ileocolic intussusception, supporting its safe use for analgesia during the painful reduction procedure.
Basophil Activation Test: A Superior Predictor for Allergic Reactions to Baked and Fresh Cow’s Milk in Children
The Basophil Activation Test offers the highest accuracy in predicting allergic reactions to baked and fresh cow’s milk during oral food challenges, reducing the need for riskier diagnostic tests in children with milk allergy.
Advancing Early Pediatric Sepsis Detection: Machine Learning Models Predicting Onset Within 48 Hours
This study developed and validated machine learning models with high accuracy to predict early pediatric sepsis and septic shock within 48 hours using multisite electronic health record data in emergency departments.
Everolimus and Low-Dose Tacrolimus Therapy After Pediatric Heart Transplant: Insights from a Multicenter Randomized Clinical Trial
This randomized trial evaluates the safety and efficacy of everolimus combined with low-dose tacrolimus versus standard immunosuppression in children 6 months post-heart transplant, highlighting comparable rejection rates, improved kidney f
Pharmacological Treatments for Pediatric Functional Constipation: A Comprehensive Systematic Review and Meta-Analysis
This systematic review and meta-analysis evaluates the efficacy and safety of pharmacological therapies for functional constipation in children, identifying polyethylene glycol as the preferred first-line treatment based on moderate-certain
Long-Term Sequelae in Survivors of High-Risk Neuroblastoma: Insights from the Children’s Oncology Group Study
This study reveals significant late effects in childhood neuroblastoma survivors, emphasizing the need for targeted long-term follow-up care based on treatment exposures.
Smoothing the Leap to Adult Care: EU‑CAYAS‑NET Recommendations for Transition of Childhood and Adolescent Cancer Survivors
EU‑CAYAS‑NET issues 44 strong, evidence‑based recommendations to standardize and improve transitions from paediatric to adult survivorship care for those diagnosed with cancer at 0–21 years, emphasizing planned transfer, risk‑based follow‑u
Unveiling Distinct Biological Subtypes of Chronic GVHD in Pediatric Hematopoietic Cell Transplantation: Toward Personalized Management
Recent research identifies three unique biological subtypes of chronic graft-versus-host disease (cGvHD) in children post-hematopoietic cell transplantation, offering potential pathways for tailored treatments and improved outcomes.
Molecular Monitoring of MRD in Pediatric AML with KMT2A::MLLT10: Prognostic Insights and Clinical Impact
MRD monitoring by RT-qPCR in pediatric AML with KMT2A::MLLT10 fusion identifies patients at high risk despite morphologic remission, informing prognosis and guiding therapy.
Personalized Prediction of Platelet Transfusion Outcomes in Preterm Infants with Severe Thrombocytopenia
A dynamic model predicts individualized risk of major bleeding or death with or without prophylactic platelet transfusion in preterm infants, allowing tailored clinical decisions based on evolving patient status.
Decoding the Optimal Aerobic Exercise Dose for Alleviating Depression in Youth: Evidence from a Meta-Analysis
Aerobic exercise significantly alleviates depressive symptoms in children and adolescents, especially in diagnosed adolescents, with 590 METs-min/week at moderate intensity identified as the optimal dose.
Clinical Decision Tool Integrating Decision Tree, Point-of-Care CRP Testing, and Safety Netting to Optimize Antibiotic Use in Acutely Ill Children: Evidence from the ARON Pragmatic Trial and Contextual Literature
The ARON trial demonstrated that a clinical decision tool combining decision tree, point-of-care CRP testing, and safety-netting advice safely reduces antibiotic prescribing in acutely ill children without delaying recovery or increasing he
Tirzepatide Shows Promising Efficacy and Safety in Managing Youth-Onset Type 2 Diabetes: Insights from the SURPASS-PEDS Trial
The phase 3 SURPASS-PEDS trial demonstrates that tirzepatide significantly improves glycaemic control and reduces BMI in children and adolescents with type 2 diabetes, with a safety profile consistent with adult studies.
Budesonide-Formoterol Reliever Therapy Demonstrates Superiority over Salbutamol in Children with Mild Asthma: Insights from the CARE Trial
The CARE trial shows that budesonide-formoterol reliever monotherapy significantly reduces asthma attack rates compared to salbutamol in children aged 5-15 years with mild asthma, with comparable safety over 52 weeks.
Evaluating Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: Insights from the BiB Randomized Clinical Trial
The BiB trial showed that adding budesonide to surfactant did not reduce bronchopulmonary dysplasia or death in extremely preterm infants but was associated with increased hyperglycemia risk.
Browse by specialty
Open language-specific specialty feeds and department pages.