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The Baby-OSCAR trial demonstrates that early selective treatment of large patent ductus arteriosus with ibuprofen in extremely preterm infants does not significantly reduce death or bronchopulmonary dysplasia, nor does it improve neurodevel
The TREOCAPA randomized clinical trial demonstrates that while prophylactic intravenous acetaminophen effectively promotes patent ductus arteriosus closure in extremely preterm infants, it does not significantly increase survival without se
A large-scale analysis of the MYRIAD trial indicates that universal school-based mindfulness training does not superiorly reduce depression risk in adolescents. While machine learning identified certain potential responders, the clinical be
The IMPAACT 2017/MOCHA study reveals that long-acting injectable cabotegravir and rilpivirine administered every eight weeks is safe and highly effective for adolescents with HIV, potentially transforming the landscape of pediatric HIV care
A landmark longitudinal study reveals that 10.6 million children experience serious health-related suffering annually, with a critical shift toward survivors requiring long-term palliative support rather than end-of-life care, predominantly
The NAPSACC UK cluster RCT found that a one-year environmental intervention in early childhood education settings did not significantly improve total energy consumption or physical activity, highlighting the need for broader policy-level ch
The SCIENCE multicentre randomized trial demonstrates that surgical fixation for displaced medial epicondyle fractures in children provides no functional advantage over non-surgical care, carries higher complication risks, and is not a cost
Ancillary analysis of the ODYSSEY trial demonstrates that dolutegravir-based ART is not associated with excessive weight gain or adiposity in children and adolescents compared to standard care, while offering a superior metabolic profile ov
The PIPPA Tamariki randomized controlled trial demonstrates that using paracetamol versus ibuprofen as needed in the first year of life does not significantly alter the risk of developing eczema or bronchiolitis by age one, challenging long
A 30-year analysis reveals that 10.6 million children experience serious health-related suffering annually, with a massive shift toward chronic, non-decedent care needs in low- and middle-income countries.
A multicenter randomized trial of 1,082 extremely preterm infants found that automated FiO2 control did not significantly reduce death or major morbidities compared to manual titration, though it remains a safe labor-saving tool for neonata
This population-based cohort study of over 1 million births reveals that maternal multiple chronic conditions (MCC) significantly increase the risk of severe neonatal morbidity and mortality, with risks escalating alongside the number, comp
A nationwide study reveals that adolescent liver transplant recipients receiving grafts from donors 10+ years older face a 12.7% reduction in 10-year graft survival. Expanding allocation radii could improve access to age-matched organs and
A longitudinal study of the ENVIRONAGE cohort reveals that blood pressure tracks consistently from birth through childhood, with higher neonatal readings significantly increasing the risk of hypertension by age 11, emphasizing the need for
This study reveals that young adults with childhood-onset complex chronic conditions (4Cs) account for over 10% of hospital bed-days despite being a small patient volume. They face longer stays, higher costs, and frequent readmissions, high
A randomized trial involving 100 extremely preterm infants shows that cerebral oximetry-guided treatment using a standardized guideline and NIRS device significantly reduces the burden of cerebral hypoxia and hyperoxia during the first five
A retrospective cohort study of nearly 1.2 million infants demonstrates that while vegan family diets are associated with a slight initial risk of underweight, long-term growth trajectories for length, weight, and head circumference converg
A randomized trial demonstrates that standardized treatment guided by cerebral oximetry reduces cerebral oxygenation instability by over 40% in extremely preterm infants, offering a precise new strategy for neonatal neuroprotection.
A landmark study using CDC ADDM Network data reveals significantly elevated mortality risks for young adults with autism, intellectual disability, and cerebral palsy, highlighting a critical need for improved transition-of-care strategies a
This comprehensive systematic review and meta-analysis of 190 studies involving 2.8 million participants establishes a 4.7% incidence rate for childhood food allergy and identifies early atopic conditions, microbiome disruptions, and delaye
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