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A multicenter study shows that observation with deferred CT decision-making significantly reduces CT use in children with blunt abdominal trauma, particularly in cases with intermediate clinician suspicion, without increasing missed injurie
A novel statistical model predicts chronic immune thrombocytopenia (ITP) in children at diagnosis, using age, sex, immunoglobulin levels, and lab values, offering early clinical guidance.
An IRIS Registry analysis of 17.5 million procedures found endophthalmitis was rare overall but highest after open globe repair, with pediatric cataract surgery carrying more risk than adult surgery.
A nationwide cohort study of 466,462 infants reveals that maternal pregestational diabetes significantly increases the risk of delayed developmental milestones, with type 1 diabetes conferring the highest risk and female offspring showing p
Secondary analysis of the MYRIAD trial reveals that while machine learning models can identify adolescents who may benefit from school-based mindfulness training, the clinical relevance of such predictions remains minimal. Both causal fores
A single-center retrospective study of 69 pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia reveals that TP53 alterations significantly compromise outcomes following tisagenlecleucel therapy. Pa
A 3-year prospective study demonstrates sustained biochemical and clinical improvements with burosumab in XLH patients across pediatric and adult age groups, including those typically excluded from clinical trials.
In pediatric autoimmune hyperthyroidism, a higher FT3/FT4 ratio predicted relapse after antithyroid drug withdrawal, especially when orbitopathy was present.
The PHC HOD08 study demonstrates that an 8-week dose-dense modified Stanford V regimen achieves high complete response rates, allowing over 75% of low-risk pediatric Hodgkin lymphoma patients to avoid radiotherapy while maintaining an excep
This report examines the role of Intestinal Ultrasound (IUS) in pediatric Acute Severe Ulcerative Colitis (ASUC). Results from 60 patients show that IUS metrics, specifically colonic wall thickness and the Milan Ultrasound Score, can accura
A landmark study using lesion network mapping reveals that cerebral palsy after neonatal stroke is driven by disruptions in extensive functional networks, including the thalamus and cerebellum, rather than just localized motor cortex damage
This article examines the landmark findings from the National Pediatric Prehospital Readiness Project, identifying critical gaps in emergency care for children and highlighting the transformative role of Pediatric Emergency Care Coordinator
The first national assessment of US EMS agencies reveals a critical need for improved pediatric readiness. While equipment scores are high, significant gaps exist in quality improvement and family-centered care, with Pediatric Emergency Car
Recent research highlights a standardized multidisciplinary protocol for managing unilateral vocal fold immobility in infants after cardiothoracic surgery, showing that injection laryngoplasty significantly improves oral feeding advancement
A prospective study of over 700,000 newborns demonstrates that LC-MS/MS significantly improves the positive predictive value (PPV) of CAH screening compared to traditional RIA, identifying specific steroid ratios that offer 100% PPV and red
This review analyzes the significant long-term thyroid toxicity burden in high-risk neuroblastoma survivors, identifying key risk factors such as molecular radiotherapy, tandem myeloablative therapy, and immunotherapy.
A 16-year follow-up of the SVR trial reveals that while shunt types show similar long-term outcomes overall, pre-existing tricuspid regurgitation significantly impacts survival with RVPAS, amid a staggering 87% rate of major morbidity.
This meta-analysis reveals that long-acting growth hormone (LAGH) is associated with a significant increase in BMI SD scores during the first year of treatment and upon switching from daily GH, suggesting a distinct metabolic profile compar
A breakthrough study reveals that specific FBN1 genotypes, particularly in-frame variants in the DNCD region, significantly elevate the risk of early mitral valve surgery in Marfan syndrome patients, paving the way for genotype-guided clini
The ORION-16 trial demonstrates that inclisiran, a twice-yearly siRNA therapy, significantly and safely reduces LDL cholesterol in adolescents with heterozygous familial hypercholesterolaemia, offering a promising solution for long-term adh
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