Dose-Dependent Radiation and Chemotherapy Risks for Colorectal Subsequent Malignancies in Childhood Cancer Survivors: Clinical Implications from a CCSS Analysis
Highlights
– In 25,723 five‑year childhood cancer survivors (median follow‑up 28.5 years), colorectal subsequent malignant neoplasms (SMNs) were strongly associated with mean colorectum dose (MCD) and irradiated colorectal volume in a dose‑dependent manner.
– Specific chemotherapy exposures showed independent and dose‑dependent risks: procarbazine demonstrated a steep linear excess rate ratio (ERR) per 1,000 mg/m2, and high cumulative doses of alkylators and platinum were also associated with markedly increased colorectal SMN incidence.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.