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Intravitreal pegcetacoplan significantly slowed geographic atrophy progression by 41% over two years, maintaining efficacy in clinical practice for AMD patients, with stable visual acuity decline and manageable safety.
This retrospective cohort study compares visual field progression after repeat trabeculectomy versus Ahmed glaucoma valve implantation in eyes with prior trabeculectomy failure, revealing similar postoperative visual outcomes but greater in
A novel, cumulative risk factor approach identifies patients at increased risk for additional retinal intervention after laser retinopexy for retinal tears, improving surveillance and management strategies.
A large retrospective cohort study suggests that cetirizine, ibuprofen, and prednisone use in adults with type 2 diabetes is associated with significantly reduced incidence of diabetic macular edema and proliferative diabetic retinopathy, h
This study reveals significant shifts in the bacterial spectrum, antimicrobial resistance, and clinical presentation of acute postcataract endophthalmitis over 23 years, underscoring the need for updated surveillance and tailored treatment
A case series delineating a novel EFEMP1 variant, p.Arg140Trp, associated with late-onset peripheral retinal degeneration distinct from classic DHRD/ML, highlighting rod dysfunction precedes structural changes.
This article examines the critical need for refined clinical metrics in thyroid eye disease (TED) to better evaluate new targeted therapies, highlighting the Innovate TED Initiative’s efforts to develop and validate comprehensive outcome me
This study elucidates how ribbon-type reticular pseudodrusen, especially when coexisting with soft drusen, significantly impair retinal sensitivity in intermediate AMD, highlighting the importance of lesion phenotype in functional risk asse
This study reveals that 30.7% of atopic dermatitis patients treated with dupilumab develop ocular surface disease, despite prevalent ocular symptoms at baseline and increased ophthalmic treatment during therapy, linked to reduced conjunctiv
Phase 3 trials show satralizumab significantly improves proptosis, inflammation, and diplopia in thyroid eye disease with a favorable safety profile, marking a new therapeutic option targeting the IL-6 receptor pathway.
A significant proportion of real-world diabetic macular edema patients are excluded from clinical trials of anti-VEGF therapy due to stringent systemic criteria, disproportionately affecting racial minorities. This study highlights the need
This review synthesizes evidence linking cumulative atopic diseases—including asthma, atopic dermatitis, and allergic rhinitis—to keratoconus risk, highlighting a dose-dependent association and the role of healthcare utilization in case asc
Central obesity in women and high overall body fat in men are linked to increased odds of dry eye disease, with distinct metabolic pathways implicated, based on a retrospective analysis of over 480,000 UK Biobank participants.
This review synthesizes recent evidence on event-based progression detection in glaucoma, highlighting that OCTA vessel density may identify progression earlier than structural OCT or visual field testing, with important implications for cl
This review synthesizes longitudinal evidence on 3D eye shape remodeling in high myopia, linking distinct morphologic trajectories to sight-threatening outcomes and supporting individualized risk stratification beyond axial length alone.
This review synthesizes evidence from the TEASE-1 trial and related studies on gildeuretinol acetate, highlighting its safety profile and modest efficacy in slowing retinal atrophic lesion growth in Stargardt disease over 24 months.
A large-scale PubMed analysis reveals that one in five ophthalmology studies report null primary outcomes, with declining prevalence over time and notable differences in funding, design, and journal impact between null and positive studies.
Increasing neighborhood socioeconomic deprivation is associated with reduced adherence to annual diabetic retinopathy screening among Medicare patients, highlighting disparities in preventive eye care.
A 10-year Korean cohort study reveals that retinal arteriosclerosis, intraocular pressure, age, serum uric acid, and cholesterol levels significantly increase the risk of structural glaucoma conversion.
Virtual reality-based digital defocus vision training (DDVT) shows promise as a home-based adjunct to slow myopia progression in children, with randomized trial data demonstrating modest reductions in axial length and refractive error progr
