Oncology
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Robotic Gastrectomy Outperforms Open and Laparoscopic Surgery in Gastric Cancer Outcomes
A retrospective study reveals robotic gastrectomy achieves higher textbook outcome rates than laparoscopic and open surgery, correlating with improved 1-year survival in gastric cancer patients.
Selective vs. Universal NGS in Endometrial Cancer: A Cost-Efficiency Breakthrough
A new study reveals that selective molecular profiling with MMR/p53 IHC followed by NGS for p53-abnormal tumors is more cost-efficient than universal NGS for advanced endometrial cancer, reducing unnecessary testing by 57%.
A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models
The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.
Inflammatory and Cardiac Biomarkers Predict VTE and Bleeding Risks in Cancer Patients
Elevated levels of inflammatory and cardiac biomarkers are linked to higher risks of venous thromboembolism and bleeding in cancer patients, according to a post hoc analysis of the AVERT trial.
Survival of Patients Diagnosed With Cancer During the COVID-19 Pandemic
A cohort study of over 1 million cancer patients revealed significant reductions in 1-year survival rates during 2020-2021 compared to pre-pandemic trends, with an estimated 17,390 excess cancer deaths attributable to pandemic-related care
Breaking Ferroptosis Resistance: PRMT5 Inhibition Emerges as a Game-Changer in B-Cell Lymphoma Therapy
PRMT5 inhibition sensitizes B-cell lymphomas to ferroptosis by disrupting the PRMT5-ATF5-SLC7A11 axis, offering a novel therapeutic strategy for relapsed or refractory disease.
Adequate Lymph Node Dissection May Carry a Survival Signal in Intrahepatic Cholangiocarcinoma
An updated meta-analysis suggests lymph node dissection in intrahepatic cholangiocarcinoma may improve survival when it is truly adequate, especially when at least six nodes are retrieved and confounding is reduced.
Prophylactic Antibiotics Did Not Significantly Reduce Infection After Vulvar Surgery, Cohort Study Finds
In a prospective cohort of 172 vulvar surgery patients, prophylactic antibiotics were not associated with fewer postoperative infections or complications, supporting the need for a randomized trial.
Validation of the 2025 ATA Risk Stratification System in a Cohort of Patients with Papillary Thyroid Carcinoma
A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.
2025 ATA Risk Stratification for Papillary Thyroid Cancer: Validation Study Reveals Significant Reclassification Shifts
A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new ‘low-intermediate-risk’ class emerges as a distinct entit
Early FDG-PET Predicts Survival Outcomes in Metastatic Breast Cancer: IMPACT-MBC Trial Reveals Rapid Response Imaging as a Powerful Prognostic Tool
The IMPACT-MBC trial demonstrates that performing FDG-PET after just 2 weeks of first-line systemic therapy can accurately identify metastatic breast cancer patients with distinct long-term outcomes, potentially improving treatment decision
AI Models for EGFR Prediction in Lung Cancer Show Ancestry-Based Performance Gaps
A cohort study reveals that open-source AI pathology models predicting EGFR mutations in lung adenocarcinoma demonstrate variable performance across ancestral groups, with notably lower accuracy in Asian patients (AUC 0.68) compared to Euro
Nine-Valent HPV Vaccine Cuts Cancer Risk Nearly in Half for Males: Landmark Study Supports Sex-Neutral Immunization
A large-scale retrospective cohort study demonstrates that 9-valent HPV vaccination in males aged 9-26 years is associated with a 46% reduction in HPV-related cancer risk. The findings support sex-neutral HPV vaccination strategies and high
ICG Fluorescence-Guided Lymphadenectomy Shows Promise in Improving Lymph Node Detection During Esophagectomy for Esophageal Cancer
A prospective cohort study of 30 patients demonstrates that indocyanine green near-infrared fluorescence imaging during minimally invasive esophagectomy achieves 80% sensitivity and 99.4% negative predictive value for detecting malignant ly
From 19 to 2: How a Simplified DNA Test Could Revolutionize Endometrial Cancer Detection
Researchers successfully reduced a 19-marker DNA panel to just 2 methylated DNA markers that detect endometrial cancer with 96% sensitivity and 82% specificity using self-collected vaginal fluid, offering a less invasive alternative to endo
Perioperative Nivolumab Combined with Irreversible Electroporation Shows Antitumoral Effect in High-Risk BCLC A Hepatocellular Carcinoma: Results from the NIVOLEP Phase 2 Trial
The NIVOLEP phase 2 trial demonstrates that perioperative nivolumab (neoadjuvant and adjuvant) combined with irreversible electroporation achieves 70.6% one-year local recurrence-free survival in BCLC A HCC patients with high recurrence ris
Three Modifiable Factors Predict Emotional Impairment in Thyroid Cancer Patients: What Clinicians Need to Know
A prospective study identifies exhaustion, head and neck discomfort, and body image concerns as independent predictors of poor emotional functioning in differentiated thyroid carcinoma patients. These findings highlight actionable targets f
Long-Term NSCLC Survivors After Pembrolizumab Show High Survival Rates, Rare Immunotherapy Rechallenge
A nationwide French cohort study reveals that advanced NSCLC patients completing 2 years of pembrolizumab maintain excellent survival outcomes, with most remaining treatment-free and immunotherapy rechallenge being uncommon.
When Targeting Becomes a Double-Edged Sword: How Loss of GPRC5D May Fuel Multiple Myeloma Progression
Researchers discovered that loss of GPRC5D, a key immunotherapy target in multiple myeloma, not only confers resistance to targeted therapies but actively promotes cancer cell proliferation and competitive fitness—creating a therapeutic par
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