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Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs
A small retrospective series suggests that cricopharyngeus-targeted procedures can improve upper esophageal sphincter opening and oral intake after neurological injury, but aspiration risk often persists and ongoing swallowing therapy remai
A long-term stroke study found that cognition improves most within 6 months, with memory and language recovering better than executive function. Early cognitive impairment was the strongest predictor of outcomes years later.
In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.
In the REGARDS cohort, prior myocardial infarction, including silent MI, was linked to faster long-term cognitive decline, suggesting heart attack history may help identify people at risk for future cognitive impairment.
Real-world registry data suggest that reversing dabigatran with idarucizumab before IV thrombolysis in acute ischemic stroke is safe and yields outcomes similar to patients not on oral anticoagulants.
A 24-month randomized trial found that exercise, intensive blood pressure and cholesterol control, or both together did not significantly improve cognitive function in older adults at increased risk for dementia.
A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im
In a sham-controlled trial, translumbosacral neuromodulation with 2400 or 3600 magnetic pulses reduced fecal incontinence episodes, improved severity scores and quality of life, and was well tolerated, with the higher dose showing the stron
A large international registry study found that hemorrhage in dural arteriovenous fistulas is driven mainly by venous anatomy and lesion grade, not most cardiovascular comorbidities. Surgery was most associated with angiographic cure, and b
In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.
In adults with MOGAD, stopping maintenance therapy was associated with a low 1-year relapse risk, especially after longer treatment and a longer relapse-free interval. The findings support individualized decisions and close follow-up after
The DISTAL trial found no 12-month disability or survival benefit from adding endovascular treatment to best medical therapy in mild-to-moderate medium or distal vessel occlusion stroke.
In nearly 483,000 UK Biobank participants, sarcopenia, low grip strength, and slow walking pace were associated with higher risks of incident stroke and poorer survival after stroke.
A large Ontario population study found that people with multiple sclerosis received palliative care at rates similar to other decedents, yet rural inequities and frequent hospital death persisted, highlighting the need for earlier neuropall
In the IAT-TOP randomized trial, intra-arterial alteplase after successful EVT for acute basilar artery occlusion did not improve 90-day functional independence, while symptomatic intracranial hemorrhage and mortality were similar between g
A large multinational RES-Q registry analysis suggests that the benefit of bridging thrombolysis before thrombectomy is greatest when treatment starts very early, with attenuation after 150 minutes.
A single-center cross-sectional study found that iatrogenic cerebral amyloid angiopathy carries a higher amyloid PET burden, weaker CSF-PET coupling, and less APOE ε4 enrichment than sporadic disease, supporting a biologically distinct mech
In a phase 2 randomized trial, oral vemircopan did not improve clinical outcomes over placebo in AChR-antibody–positive generalized myasthenia gravis, despite a mechanistically attractive strategy to selectively inhibit the alternative comp
In a prospective mild stroke cohort, cranial arterial dolichoectasia and larger intracranial arterial diameters were linked to lacunar stroke, cSVD burden, and incident infarcts, whereas large-artery stenosis was not.
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