Social Determinants of Health in Early to Mid-Adulthood and Risk of Early-Onset Stroke: A Comprehensive Review

Highlights

• Adverse social determinants of health (SDOH) in early to mid-adulthood are independently associated with an increased risk of early-onset stroke.
• A dose-dependent relationship exists: individuals exposed to multiple adverse SDOH domains have a substantially higher stroke risk.
• Key SDOH domains linked to stroke include lower household income, lower educational attainment, neighborhood deprivation, and lack of health insurance.
• Racial and sex disparities modulate the impact of SDOH on stroke risk, with Black individuals and women showing stronger associations.

Background