Emergency Medicine
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Combination Therapy Fails to Outperform Ibuprofen Alone for Pediatric Musculoskeletal Pain: Evidence from Two Randomized Controlled Trials
New clinical trials reveal that adding acetaminophen or hydromorphone to ibuprofen provides no additional pain relief for children with acute musculoskeletal injuries, while the addition of opioids significantly increases the risk of advers

Cast Immobilization is Non-inferior to Surgery for Unstable Weber B Ankle Fractures: Results from the SUPER-FIN Trial
The SUPER-FIN randomized trial reveals that cast immobilization is a viable, non-inferior alternative to surgery for unstable Weber B ankle fractures with a congruent mortise, leading to fewer complications and avoiding unnecessary hardware

Simplifying Pulmonary Embolism Exclusion: Can One Clinical Question Safely Reduce Imaging?
A prospective multicenter study demonstrates that using a single clinical question—whether pulmonary embolism is the most likely diagnosis—to adjust D-dimer thresholds can safely reduce chest imaging by 19% in emergency departments without

Age-Adjusted D-Dimer Cutoffs Safely Rule Out Deep Vein Thrombosis: Results from the ADJUST-DVT Trial
The ADJUST-DVT study confirms that an age-adjusted D-dimer cutoff (age × 10 µg/L) safely increases the number of patients in whom deep vein thrombosis can be ruled out without imaging, particularly benefiting patients over 75 years of age.

New Benchmarking Standard: Validated Risk Models for Survival and ROSC in Out-of-Hospital Cardiac Arrest
Researchers in England have developed and validated multivariable risk adjustment models for ROSC and survival following out-of-hospital cardiac arrest. These models provide a robust framework for benchmarking EMS performance and driving qu

Hypertensive Response in Advanced Conduction Disorders: A Paradoxical Marker of Haemodynamic Resilience?
Recent research reveals that nearly half of patients with high-degree AV block present with hypertension, a phenotype characterized by preserved cardiac function and higher peripheral vascular resistance, leading to better short-term clinic

The Price of Time: 20-Year Study Reveals Pre-Hospital Delay as a Critical Driver of STEMI Mortality
A 20-year analysis of 89,155 patients from the SWEDEHEART registry confirms that pre-hospital delay independently predicts short- and long-term mortality. Despite advances in reperfusion, women, elderly patients, and those with diabetes con

Awake Prone Positioning in COVID-19 Respiratory Failure: A Synthesis of Clinical Trial Evidence and the PROVID Study
This review synthesizes the findings of the PROVID randomized clinical trial and broader literature, demonstrating that awake prone positioning (APP) significantly reduces the probability of intubation and death in patients with COVID-19 hy

One in Three Older Emergency Admissions Face Cognitive Morbidity: Insights from the ORCHARD-EPR Study
A large-scale cross-sectional study of 51,202 admissions reveals that 35.6% of patients aged 70 and older experience cognitive morbidity, predominantly delirium. The findings underscore the urgent necessity for hospital-wide screening and m

High-Sensitivity Cardiac Troponin Risk Stratification Safely Accelerates ED Discharge and Improves 1-Year Outcomes
A secondary analysis of the HiSTORIC trial reveals that using high-sensitivity cardiac troponin for risk stratification significantly reduces ED length of stay and increases safe discharge rates for low- and intermediate-risk patients, with

Beyond Troponin: Cardiac Myosin-Binding Protein C Accelerates NSTEMI Diagnosis and Emergency Department Triage
A secondary analysis of the APACE study demonstrates that Cardiac Myosin-Binding Protein C (cMyC) significantly improves NSTEMI diagnosis, particularly in early presenters. Integrating cMyC with high-sensitivity troponin into a dual-biomark

The Earlier, the Better: INTERACT Pooled Analysis Confirms 3-Hour Golden Window for Intensive Blood Pressure Lowering in Acute ICH
A pooled analysis of over 11,000 patients from the INTERACT trials demonstrates that intensive blood pressure reduction significantly improves functional recovery in acute intracerebral hemorrhage, with the most robust benefits observed whe

Telemedicine is Superior to Onboard Neurologists for Optimizing Mobile Stroke Unit Efficiency: Results from the MSU-TELEMED Trial
The MSU-TELEMED trial demonstrates that a telemedicine model for mobile stroke units significantly improves neurologist resource utilization while maintaining safety, outperforming the traditional onboard neurologist model in a hierarchical

Remote Expertise, Local Impact: Telemedicine Models Outperform Onboard Care in Mobile Stroke Units
The MSU-TELEMED trial demonstrates that telemedicine models for Mobile Stroke Units are superior to onboard neurologist care. By dramatically improving physician resource utilization without compromising safety, telemedicine provides a more

Superior Early Analgesia with PENG Block in Hip Fractures: A Randomized Controlled Trial
A randomized trial demonstrates that the Pericapsular Nerve Group (PENG) block provides significantly better pain relief than the Fascia Iliaca Block (FIB) in the first hour post-intervention for hip fracture patients in the emergency depar

POCUS-Guided Nerve Blocks by Emergency Physicians Significantly Reduce Delirium Risk in Elderly Hip Fracture Patients
A multicenter randomized trial reveals that a brief, structured training intervention for emergency physicians significantly increases the use of ultrasound-guided fascia iliaca blocks, resulting in a 28% reduction in delirium risk for geri

Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI
A multicenter cohort study of 555 patients with severe TBI who underwent prehospital rapid sequence induction found postintubation hypotension (SBP

Why Emergency Medicine Residents Rarely Choose Surgical Critical Care — A Nationwide Survey and a Roadmap to Increase EM-SCC Matriculation
A national survey of 111 emergency medicine trainees identifies limited exposure to surgical critical care, institutional and geographic factors, and program characteristics (ECMO, multidisciplinary teams) as key modifiable drivers of low E

Predicting Serious Bacterial Infections in Young Infants with Fever: A Safer Approach to Lumbar Punctures
An updated clinical prediction tool accurately identifies invasive bacterial infections in infants under 28 days old, potentially reducing unnecessary lumbar punctures while ensuring no cases of bacterial meningitis are missed.

ED-Delivered Education Plus mHealth Lowers Systolic BP — TOUCHED Trial Shows a Modest but Meaningful 4.9 mm Hg Reduction at 6 Months
The TOUCHED randomized trial found that an ED-initiated education plus mHealth and pharmacist/APRN consultation reduced systolic blood pressure by 4.9 mm Hg at 6 months versus usual care in patients discharged with elevated BP.
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