Emergency Medicine
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Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes
A multicenter emergency department study found that CPES performed similarly to sPESI and ESC for short-term PE outcomes, but it better predicted the need for advanced intervention.
DISTAL at 12 Months: No Functional or Survival Advantage for Endovascular Therapy in Mild-to-Moderate Medium or Distal Vessel Occlusion Stroke
The DISTAL trial found no 12-month disability or survival benefit from adding endovascular treatment to best medical therapy in mild-to-moderate medium or distal vessel occlusion stroke.
Adjunct Intra-arterial Alteplase After Successful Basilar Thrombectomy Was Safe but Did Not Improve 90-Day Outcomes in IAT-TOP
In the IAT-TOP randomized trial, intra-arterial alteplase after successful EVT for acute basilar artery occlusion did not improve 90-day functional independence, while symptomatic intracranial hemorrhage and mortality were similar between g
A New hs-cTnT Generation 6 Assay Matches Generation 5 for Myocardial Infarction Diagnosis While Labeling Fewer Patients as Myocardially Injured
In suspected myocardial infarction, hs-cTnT-gen6 showed diagnostic accuracy comparable to gen5, produced fewer myocardial injury classifications, and supported highly sensitive ESC 0/1-hour and 0/2-hour rule-out and rule-in pathways using a
TEE-Guided Chest Compression Targeting During ED Resuscitation Did Not Improve Clinical Outcomes in Out-of-Hospital Cardiac Arrest
In EXECT-CPR, transesophageal echocardiography-guided adjustment of compression site during emergency department CPR did not significantly improve ROSC or survival, despite signals of improved hemodynamics and no excess safety concerns.
Earlier IV Thrombolysis Before Thrombectomy Was Linked to Better In-Hospital Stroke Outcomes in RES-Q
A large multinational RES-Q registry analysis suggests that the benefit of bridging thrombolysis before thrombectomy is greatest when treatment starts very early, with attenuation after 150 minutes.
Ambient AI Scribes Reduced Emergency Department Documentation Time, but Early Adoption Was Limited and Highly Concentrated
In a real-world academic emergency department, ambient AI scribe use was uncommon and concentrated among a small group of physicians, but when used it was associated with shorter documentation and total EHR time.
Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial
Secondary analysis of TEMPO-2 trial data reveals intracranial hemorrhage in minor stroke patients increases 90-day mortality risk threefold, with higher hemorrhage rates in tenecteplase-treated patients despite most bleeds being non-symptom
Stroke Disability and Mortality Post-ED Discharge for Dizziness: Rare but Clinically Significant
A retrospective cohort study reveals that stroke-related disability or mortality after ED discharge for dizziness is rare (0.04% incidence), with most lesions occurring in the anterior fossa. Findings underscore the need for targeted risk s
Revolutionary Sixth-Generation Troponin Assay Doubles Early MI Rule-Out Capacity
A novel sixth-gen hs-cTnT assay with a 13 ng/L threshold safely identified twice as many low-risk MI patients at ED presentation vs fifth-gen assays, achieving >99.5% NPV in multinational validation.
LEGEND Trial: A Game-Changer in Rapid Rule-Out of Acute Myocardial Infarction in the ED
The LEGEND trial demonstrates that a high-sensitivity troponin-based rule-out strategy significantly reduces hospital length of stay and cardiac testing while safely excluding acute myocardial infarction in emergency department patients.
Higher EMS Clinician Trauma Volume Linked to Lower Early Mortality in Trauma Patients
A study finds that increased annual trauma patient volume per EMS clinician is associated with significantly reduced 6-hour and in-hospital mortality rates, highlighting the importance of experience in prehospital trauma care.
Observation Reduces CT Use in Pediatric Blunt Abdominal Trauma Without Missing Critical Injuries
A multicenter study shows that observation with deferred CT decision-making significantly reduces CT use in children with blunt abdominal trauma, particularly in cases with intermediate clinician suspicion, without increasing missed injurie
How Matching Algorithms Can Uncover True Patient Counts From Emergency Medical Services Data
A novel matching approach using 911 call time and patient characteristics can effectively identify duplicate EMS responses, enabling more accurate patient-level inferences from response-based datasets with 100% sensitivity and up to 98.6% s
Sex-Specific Disparities in Syncope Management: Evidence from Clinical Trials and Real-World Outcomes
This review synthesizes evidence on sex differences in syncope management, highlighting that while men face higher admission rates and adverse events, these disparities are largely driven by baseline clinical risk factors rather than gender
Past-Year Emergency Department Utilization Patterns Among Suicide Decedents: Characterizing At-Risk Patient Populations
This study analyzes emergency department visit patterns among suicide decedents, identifying frequent users and a critical 30-day window for intervention after discharge.
Every Hour Counts: Emergency Department Boarding Linked to Increased Clinical Deterioration and Mortality
A large-scale retrospective study involving over 170,000 patients demonstrates that prolonged emergency department boarding significantly increases the odds of early clinical deterioration and 28-day mortality, emphasizing the urgent need f
Rethinking Shock Management: From Standardized Protocols to Personalized Precision Medicine
Expert consensus highlights a shift in shock treatment, emphasizing that standardized protocols must give way to personalized, physiology-driven bedside care to prevent iatrogenic injury and improve survival.
Telemedicine as a Strategic Tool for Post-Emergency Department Care Transitions: Analysis of Utilization and Safety, 2020–2022
This evidence-based review analyzes the adoption and clinical outcomes of telemedicine for post-ED follow-up, highlighting that while utilization is currently low (2.8%), it offers a safe alternative to in-person care without increasing ret
Analyzing Emergency Department Utilization Patterns Among Suicide Decedents: Characterizing At-Risk Patient Populations
This study examines the timing and frequency of emergency department visits among individuals who died by suicide. Research identifies frequent ED use as a high-risk indicator and suggests that the 30-day window following an emergency visit
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