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In a randomized crossover trial, short-term duodenal r-RORDEP1 infusion was well tolerated and produced early changes in GLP-1, GIP, insulin, C-peptide, glucose, and a measure of insulin sensitivity in healthy men.
Routine oral rivaroxaban prophylaxis in ACTH-dependent Cushing syndrome was associated with no new VTE events after implementation and no bleeding complications, suggesting it is a safe and effective preventive strategy.
In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antip
A six-week native GIP infusion did not improve glucose control in type 2 diabetes, either alone or added to semaglutide, despite raising circulating GIP levels.
Oral semaglutide improved multiple cardiovascular risk factors in high-risk type 2 diabetes, including HbA1c, weight, systolic blood pressure, inflammation, and some lipid measures, with benefits sustained over nearly four years.
Recent studies demonstrate that combining the beta-cell-targeted conjugate GLP1-E2 with low-dose anti-CD3 therapy significantly delays type 1 diabetes onset by simultaneously reducing immune infiltration and mitigating beta-cell cellular st
Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.
Blood mtDNA copy number showed a U-shaped association with future type 2 diabetes risk in younger adults, suggesting that both low and high levels may signal higher risk.
This study used immune-cell gene expression and genetic analyses to identify causal genes and immune pathways linked to type 2 diabetes and its complications, highlighting diabetic neuropathy as a distinct cluster and prioritising ten promi
Post-hoc metabolomic and lipidomic analyses from two phase 2 trials suggest retatrutide favorably remodels metabolic pathways linked to fatty acid oxidation, insulin resistance, and triglyceride composition in obesity, with and without type
Adding the Area Deprivation Index to HbA1c improved prediction of type 2 diabetes within 1 year in youth with prediabetes, highlighting the importance of socioeconomic factors in diabetes risk.
A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.
In two prospective cohorts of active, glucocorticoid-resistant thyroid eye disease, tocilizumab improved eye inflammation, proptosis, diplopia, and quality of life with acceptable safety, supporting IL-6 blockade as a promising second-line
The ELSA-Brasil study found that staging intermediate hyperglycaemia with fasting glucose plus 1-hour glucose better predicted type 2 diabetes than fasting glucose plus HbA1c, and a clinical risk score reduced unnecessary testing.
A large retrospective cohort shows that bilateral adrenal masses are usually benign and concordant, but asynchronous or discordant lesions identify a clinically important subgroup enriched for malignancy and pheochromocytoma.
CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.
In a pre-specified exploratory analysis of SURPASS-CVOT, tirzepatide reduced major kidney events versus dulaglutide in people with type 2 diabetes and cardiovascular disease, mainly by lowering new macroalbuminuria and slowing eGFR decline.
In a multi-institutional retrospective cohort, adrenalectomy for mild autonomous cortisol secretion was associated with lower mortality and less new-onset diabetes than nonoperative care, although sensitivity analysis weakened the survival
A 50-year follow-up of biliopancreatic diversion shows sustained weight loss and diabetes remission, but alarmingly high nutritional complications decades after surgery.
A large Dutch primary care cohort links subclinical hyperthyroidism to higher risks of atrial fibrillation, heart failure, and all-cause mortality, with particularly notable relative risks in younger adults and in patients with more strongl
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