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A 7 T imaging and tracer study found that adults with type 1 diabetes have abnormal postprandial hepatic glucose uptake, blunted glycogen storage, reduced suppression of endogenous glucose production, and marked metabolic heterogeneity desp
New expert recommendations guide glucocorticoid dose reduction in pediatric classic CAH patients using crinecerfont, prioritizing normal growth while minimizing long-term steroid complications.
Registry data from 55,028 youths with type 1 diabetes show common LDL hypercholesterolemia, infrequent lipid-lowering therapy, and poor attainment of recommended LDL targets.
A large multi-ancestry study shows that publicly available polygenic risk scores improve prediction of type 2 diabetes onset and selected microvascular complications across major global ancestry groups.
A nationwide Swedish cohort study found marked geographic variation in type 1 diabetes incidence, with the strongest clustering linked to residential location during the first 5 years of life and higher risk in rural, forested, and agricult
In a pooled U.S. pregnancy cohort, maternal PFAS concentrations were not associated with a higher prevalence of gestational diabetes, and fasting glucose findings were largely null.
大规模国际研究发现甲状腺功能随年龄变化存在性别和碘状态差异。虽然多数人甲状腺功能稳定且TSH轻微升高，但任何变化模式均与全因死亡风险增加1.8-2.5倍相关，这对老年甲状腺健康管理具有重要临床意义。
In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dy
In a large single-center retrospective study, ACR TI-RADS implementation decreased follow-up thyroid ultrasound but did not reduce fine-needle aspiration, surgery, cancer yield, or overall costs.
In medullary thyroid carcinoma with biochemical persistent disease after surgery, an early postoperative calcitonin doubling rate of at least 0.3/year strongly identified patients at higher recurrence risk and may help tailor surveillance i
A large multinational cohort study found that teprotumumab use in thyroid eye disease was associated with higher risks of prediabetes, diabetes, and antidiabetes medication initiation over 5 years.
In HCHS/SOL, prior gestational diabetes was linked to a proinflammatory gut microbiome, adverse metabolite patterns, and higher future type 2 diabetes risk, suggesting a plausible microbiome-mediated pathway after pregnancy.
A Spanish multicenter validation study shows that urinary free cortisol expressed as multiples of the upper limit of normal can meaningfully stratify the likelihood of ectopic ACTH secretion versus Cushing’s disease.
A landmark simulation study demonstrates that adding remote patient monitoring to continuous glucose monitoring in pediatric T1D patients significantly improves QALYs and is highly cost-effective compared to standard care.
New research comparing diabetes medications reveals GLP-1 receptor agonists lower heart failure hospitalization risk compared to DPP-4 inhibitors, while showing similar risk to SGLT-2 inhibitors in type 2 diabetes patients.
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.
Microplastics detected in thyroid tissues show higher concentrations in autoimmune thyroiditis patients, suggesting a potential environmental link to thyroid autoimmunity.
A cohort study reveals persistent ethnic disparities in type 2 diabetes risk, with migration status and mental health conditions as independent contributors, highlighting unmet needs in addressing structural determinants of health inequalit
A retrospective cohort study using AI to analyze radiology reports reveals high prevalence of incidental thyroid findings, strong association with diagnostic cascades, and potential overdiagnosis of low-risk thyroid cancers.
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