Clinical Updates
Latest news
1078 articles · 20 / page
Spontaneous Preterm Birth as a Sentinel for Cardiovascular Mortality: Insights from a National Registry Study
A large-scale Dutch cohort study reveals that women with a history of spontaneous preterm birth face a significantly elevated risk of cardiovascular mortality, with the highest risk observed in those delivering before 32 weeks of gestation.
Optimizing Postpartum Pain Management: Addressing Hospital Variation in Opioid Prescribing Following Vaginal Birth and Associated Procedures
This review analyzes significant inter-hospital variations in opioid prescribing for vaginal births with complications, highlighting the need for standardized postdischarge pain management protocols to reduce unnecessary opioid exposure.
Adipocyte-Driven Immunometabolic Suppression in Pancreatic Cancer: The 12,13-DiHOME/PPARγ/TAN Axis
This review explores how tumour-infiltrating adipocytes release 12,13-DiHOME to trigger neutrophil ferroptosis and CXCL2 production, ultimately subverting CD8+ T cell-mediated immunity in pancreatic ductal adenocarcinoma.
Rethinking Magnesium Prophylaxis for Postoperative Atrial Fibrillation in Cardiac Surgery: A Synthesis of Clinical Evidence
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
Predictors of Concurrent Endometrial Carcinoma in Minority Populations with Atypical Hyperplasia: A Synthesis of Clinical, Molecular, and Social Evidence
This review synthesizes recent evidence on concurrent endometrial carcinoma risk in atypical hyperplasia, highlighting significant disparities in minority populations, the protective role of adenomyosis, and the emergence of GLP-1 receptor
Minimal Access vs. Open Hysterectomy in Endometrial Cancer: A Critical Synthesis of Surgical and Survival Outcomes
This review synthesizes findings from a large-scale cohort study comparing laparoscopic and abdominal hysterectomy, highlighting significant surgical advantages for laparoscopy despite complex survival data.
Maternal-Fetal Alloimmunity and Gestational Outcomes: Assessing Anti-HLA Antibodies as a Risk Factor for Fetal Growth Restriction
This review explores the association between maternal anti-HLA antibodies and fetal growth restriction (FGR), synthesizing evidence that suggests an alloimmune mechanism may contribute to placental dysfunction and restricted fetal developme
Targeted Galectin-3 Inhibition for Portal Hypertension: Insights from the NAVIGATE Trial and Belapectin’s Role in MASH Cirrhosis
This review synthesizes clinical evidence for Belapectin, a Galectin-3 inhibitor, focusing on its ability to prevent esophageal varices in patients with MASH cirrhosis and portal hypertension as demonstrated in the NAVIGATE trial.
Galectin-3 Inhibition in MASH Cirrhosis: Synthesizing Evidence from the NAVIGATE Trial and Emerging Therapeutics
This review synthesizes clinical evidence for belapectin in MASH cirrhosis, focusing on its efficacy in preventing esophageal varices as demonstrated in the NAVIGATE trial and early phase 2b data.
Belapectin for the Prevention of Esophageal Varices in MASH Cirrhosis: Insights from the NAVIGATE Phase 2b Trial
This review synthesizes clinical evidence on belapectin, a galectin-3 inhibitor, highlighting its potential to reduce the incidence of esophageal varices in patients with MASH-related cirrhosis and portal hypertension, particularly at the 2
Therapeutic Mobilization: How Physical Activity Reprograms the Pancreatic Immune Microenvironment to Combat Chronic Pancreatitis
This review synthesizes recent evidence from the UK Biobank and molecular studies demonstrating that physical activity, particularly resistance exercise, restrains chronic pancreatitis by delivering muscle-derived extracellular vesicles tha
Fermentable Fiber Subtypes in Crohn’s Disease: From Primary Prevention to Mechanistic Regulation of the Gut-Immune Axis
Recent multi-omic and clinical evidence suggests that specific fermentable fibers, particularly β-glucan and inulin, significantly reduce Crohn’s Disease risk in high-risk individuals by preserving gut barrier function and modulating the mi
Microbiome-Mediated Prevention: The Role of Fermentable Fibers in Mitigating Crohn’s Disease Risk and Gut Barrier Dysfunction
Recent longitudinal and multi-omic studies identify specific fermentable fibers, particularly β-glucan and inulin, as critical factors in reducing Crohn’s disease risk by preserving gut barrier function and modulating the microbiome-inflamm
Fermentable Fibers and Crohn’s Disease Prevention: Multi-Omic Insights into β-Glucan, Inulin, and Gut Barrier Integrity
Higher intake of β-glucan and inulin is linked to a 30% reduction in Crohn’s Disease risk among high-risk individuals, mediated by improved gut barrier function, lower systemic inflammation markers, and specific microbial signatures.
Optimizing Gestational Weight Gain in Type 2 Diabetes: Clinical Evidence for Restricted Targets and Perinatal Benefits
This review synthesizes recent evidence suggesting that weight gain
Addressing the Equity Gap in Familial Hypercholesterolemia: Comparative Insights into African and European Ancestry Populations
This review analyzes evidence comparing Familial Hypercholesterolemia (FH) across ancestries, highlighting that while pathogenic variant prevalence is similar, African ancestry individuals face higher LDL-C burdens and significant risks fro
Beyond the Diagnosis: Addressing the Persistent Risk of Suicidal Self-Directed Violence in Veterans with Cancer
This review synthesizes recent longitudinal evidence on suicidal self-directed violence (SSDV) among veterans with cancer, identifying high-risk subgroups, temporal vulnerability windows, and the critical need for long-term psychological su
Longitudinal Suicide Risk in Veterans with Cancer: A Comprehensive Synthesis of Risk Factors and Temporal Trends
This review synthesizes longitudinal evidence on suicidal self-directed violence (SSDV) among veterans with cancer, identifying high-risk clinical subgroups, temporal peaks in vulnerability, and the critical need for long-term survivorship
Integrating Rare and Common Variants: The Synergistic Role of rCNVs and Polygenic Scores in Psychiatric Risk Stratification
This review synthesizes evidence on how recurrent copy number variants (rCNVs) and polygenic scores (PGSs) jointly influence psychiatric risk, highlighting their complementary roles in clinical risk assessment and the emergence of precision
Temperature Extremes and Heart Failure Decompensation: Decoding Phenotype-Specific Risks in a Changing Climate
Evidence reveals that both extreme cold and heat significantly trigger acute heart failure decompensation, with risk sensitivity varying by age and hemodynamic phenotype, necessitating targeted clinical prevention.
Browse by specialty
Open language-specific specialty feeds and department pages.